Dead reckoning (path integration) requires the hippocampal formation: evidence from spontaneous exploration and spatial learning tasks in light (allothetic) and dark (idiothetic) tests

Whishaw, Ian Q.; Hines, Dustin J.; Wallace, Douglas G.

doi:10.1016/s0166-4328(01)00359-x

Cited by 164 publications

(161 citation statements)

References 48 publications

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“…In any case, signals from retrosplenial cortex are likely to reach PPC indirectly via strong connections to the medial frontal cortex, in particular, the anterior dorsal cingulate cortex (90), which projects in turn to the PPC (57,76). The potential significance of these pathways is underscored by the observation that, unlike postrhinal and prefrontal lesions, damage to the retrosplenial cortex causes strong and lasting disruption of spatial navigation, both in the water maze (81,(91)(92)(93) and in a path-integration task testing the ability to return directly to a home base in darkness (28). The path integration impairment is as severe as after hippocampal damage (27).…”

Section: Output Pathways From Medial Entorhinal To Posterior Parietalmentioning

confidence: 99%

Navigating from hippocampus to parietal cortex

Whitlock

Sutherland

Witter

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

226

185

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The navigational system of the mammalian cortex comprises a number of interacting brain regions. Grid cells in the medial entorhinal cortex and place cells in the hippocampus are thought to participate in the formation of a dynamic representation of the animal's current location, and these cells are presumably critical for storing the representation in memory. To traverse the environment, animals must be able to translate coordinate information from spatial maps in the entorhinal cortex and hippocampus into bodycentered representations that can be used to direct locomotion. How this is done remains an enigma. We propose that the posterior parietal cortex is critical for this transformation.entorhinal cortex ͉ grid cell ͉ place cell ͉ Path integration ͉ spatial memory

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Section: Output Pathways From Medial Entorhinal To Posterior Parietalmentioning

confidence: 99%

Navigating from hippocampus to parietal cortex

Whitlock

Sutherland

Witter

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

226

185

View full text Add to dashboard Cite

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“…Indeed, detailed descriptions of animal exploration are often ignored because the structure of exploratory behavior is often assumed to be stochastic, and "very difficult to describe quantitatively" [27, p. 135]. Recently, however, a descriptive approach to the exploratory behavior of the laboratory rat has disclosed that the structure of a rats movement in an open field is far from random and is composed of specific movements that can be quantified [6,47,50]. For example, central to all exploratory behavior is the finding that rats adopt specific locations in their environment, even when that environment is relatively featureless, as home bases from which they organize exploratory trips [7,16].…”

Section: Introductionmentioning

confidence: 99%

“…Movements displayed at the home base include grooming, rearing, and turning, while excursions are circuitous and consist of a number of progressions punctuated by stops, with an upper limit on the number of stops [11,41,50]. Typically, excursions are terminated by fast, direct returns to the home base [41,43,50].…”

Section: Introductionmentioning

confidence: 99%

Movements of exploration intact in rats with hippocampal lesions

Clark

Hines

Hamilton

et al. 2005

Behavioural Brain Research

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Prompted by the theoretical prediction that damage to the hippocampus should abolish exploratory behavior, the present study examined exploratory movements in control rats and rats with hippocampal lesions produced with the neurotoxin N-methyl d-aspartate (NMDA). In four daily 30-min sessions, control and hippocampal rats were exposed to an open circular table under room lighting. Both control and hippocampal rats spent a majority of time near, and organized trips away from, a portion of the table (home base) near a large cue placed proximal to the table. On Day 1, control and HPC rats made equal numbers of head orientations and a comparable number of trips, featuring equal travel distance and numbers of stops. By Day 4, dwell times near the home base increased and other movements decreased in the control rats but the activity profile of Day 1 persisted in the hippocampal rats. The high degree of similarity in behavior between hippocampal and control rats on Day 1 and the persistence of this behavior in hippocampal rats on Day 4 suggests that the hippocampus is not necessary for the display of normal exploratory movements per se. The absence of habituation of exploration in hippocampal rats is discussed in relation to contemporary theories of hippocampal function.

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“…Although it is possible that in the early postnatal period the short returns of rat pups are guided by local cues, for longer trips at older ages it is likely that the pups are using dead reckoning, as has been suggested for adult rats (Wallace et al, 2002a(Wallace et al, ,b, 2003Whishaw & Gorny 1999;Whishaw, Hines, & Wallace, 2001). First, direct returns persisted in infra red light, in which visual cues cannot be seen.…”

Section: Discussionmentioning

confidence: 98%

The development of spatial capacity in piloting and dead reckoning by infant rats: Use of the huddle as a home base for spatial navigation

2005

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Two forms of spatial navigation, piloting using external cues and dead reckoning using self-movement cues, are manifest in the outward and homeward trips of adult rats exploring from a home base. Here, the development of these two forms of spatial behavior are described for rats aged 14-65 days using a new paradigm in which a huddle of pups or an artificial huddle, a small heat pad, served as a home base on an open circular table that the rats could explore. When moving away from both home bases, the travel distance, path complexity, and number of stops of outward trips from the home base increased progressively with age from postnatal day 16 through 22. When returning to the home bases, the return trips to the home base were always more direct and had high travel velocities even though travel distance increased with age for the longest trips. The results are discussed in relation to the ideas that: (1) the pups pilot on the outward portion of their excursion and dead reckon on the homeward portion of their excursion, and (2) the two forms of navigation and associated spatial capacity are interdependent and develop in parallel and in close association with locomotor skill.

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Dead reckoning (path integration) requires the hippocampal formation: evidence from spontaneous exploration and spatial learning tasks in light (allothetic) and dark (idiothetic) tests

Cited by 164 publications

References 48 publications

Navigating from hippocampus to parietal cortex

Navigating from hippocampus to parietal cortex

Movements of exploration intact in rats with hippocampal lesions

The development of spatial capacity in piloting and dead reckoning by infant rats: Use of the huddle as a home base for spatial navigation

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