De novo cancer incidence after kidney and liver transplantation: Results from a nationwide population based data

Abstract

The cancer risk among solid organ transplantation recipients in East-Asia has been insufficiently studied. This study estimated de novo cancer incidence in kidney and liver recipients 2008–2015, compared with the general population in Korea using nationwide data. This is a retrospective cohort study using nationwide health insurance claims data. The study population was comprised of cancer-free 10,085 kidney recipients and 3,822 liver recipients. Standardized incidence ratio (SIR) of cancer using indirect standardization was calculated. Compared with the general population, the cancer risk increased by 3.19-fold in male and 2.56-fold in female kidney recipients. By cancer type, a notably increased SIR was observed for Kaposi sarcoma, renal cancer, skin cancer, and non-Hodgkin’s lymphoma in male and for bladder cancer, renal cancer, and non-Hodgkin’s lymphoma in female kidney recipients. In liver recipients, the SIR of all cancers was 3.43 in males and 2.30 in females. In male liver recipients, the SIRs for Kaposi sarcoma, non-Hodgkin’s lymphoma, myeloid leukemia, and skin cancer and in female recipients those for non-Hodgkin’s lymphoma and liver cancer were prominent. A greatly higher SIRs for overall cancer and non-Hodgkin’s lymphoma in kidney and liver recipients aged 0–19 were observed, compared with recipients in other age group. The incidence of de novo cancer in kidney and liver recipients was higher than the general population and common types were different. Strategies of cancer prevention and screening after kidney and liver transplantation should be developed in response to the incidence of common types of de novo cancers.

Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea

“…In the present study, a comprehensive analysis of PTM after kidney transplantation was conducted based on nationwide data from Korea with a lengthy follow-up duration and information on mortality. The SIR of PTM was 3.9, similar to previous studies 11 , 16 , 17 . The SMR of total PTM was 1.4, and that of lymphoma showed the highest value (9.3 for Hodgkin lymphoma and 5.5 for NHL).…”

“…Regarding the types of PTM, the most common malignancy was thyroid cancer, followed by colorectal, kidney, stomach, and prostate cancer. The high frequency of these cancers demonstrated previously 16 , 17 may result from increased surveillance.…”

“…Most previous studies are derived from single-centre data with a relatively small number of recipients 13 – 15 . Recently Heo et al 16 and Park et al 17 found thyroid cancer to be the most common PTMs identified in from 5- and 8-year nationwide databases, respectively. The relatively short mean duration of follow-up may affect the accuracy of data concerning late-onset PTM.…”

Cancer morbidity and mortality after pediatric solid organ transplantation—a nationwide register study

“…Among the adult recipients, cancer incidence increases further along the time from transplantation [ 24 ], which is at least partly explained by the higher incidence of cancer at older age in general. In the present study, the majority of cancers were diagnosed at young adult age, and a study by Park et al [ 25 ] showed that highest risk for post-transplant malignancy was among transplant age group 0–19 years.…”

Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort Studies

“…Supplementary Table S3 provides details of the included studies, which involved e1848068-2 a total of 2,105,122 solid organ transplant recipients and reported 45 types of site-specific cancer. Of them, 52 studies 7,8,75 provided SIRs of multiple cancers of solid organ transplantations (11 for multiple organs, 7,8,[17][18][19][20][21][22][23][24][25] 19 for kidney, [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] 16 for liver, [45][46][47][48][49][50][51][52][53][54][55]75 7 for heart and/or lung [60][61][62][76]…”