DBU-catalyzed expeditious and facile multicomponent synthesis of N-arylquinolines under microwave irradiation

Abstract

N-Arylquinoline derivatives are obtained in excellent yields by a rapid, easy, and efficient one-pot multicomponent reaction of aromatic aldehydes, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds utilizing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a catalyst in ethanol under microwave irradiation.

Eco‐Efficient Synthesis of New Pyrido [2, 3‐c] Coumarin Scaffolds Under Sonochemical Method

“…Hantzsch DHP synthesis is one of the most broadly used methods for the preparation of DHPs. In order to improve the efficiency of Hantzsch DHPs synthesis, different catalysts have been explored, and many of them exhibited excellent catalytic activity , such as L‐proline , S‐Valin , Yb(OTf) 3 , molecular I 2 , TBAHS , HOAc , Et 3 N , DBU , Py , ceric ammonium nitrate (CAN) , and so on. These methods, however, suffer from drawbacks such as the use of expensive catalysts, difficulty in availability or preparing the starting materials or catalysts, the environmental pollution caused by utilization of solvents and homogeneous catalysts, low yields, long reaction times, tedious work‐up, waste control, and formation of side products.…”

Facile one-pot, three-component synthesis of novel fused 4H-pyrans incorporating 2-phenoxy-N-phenylacetamide core as novel hybrid molecules via Michael addition reaction

“…It is an extremely effective technique in drug discovery, heterocyclic, and combinational chemistry. [1][2][3][4][5][6][7] Molecular hybridization is a good drug-design and development technique that focuses on combining various pharmacophores to create novel, pharmacologically-active molecules. The primary objective is to boost therapeutic efficacy while reducing side effects and preventing medication resistance.…”

Polybenzimidazole-Triphenylphosphene-Catalyzed One-Pot Synthesis and Evaluation of Dihydropyridine Derivative as Antibiotics and Antifungals

“…In addition, the literature survey reveals that the following different types of catalysts have been used in the synthesis of DHP derivatives, metal/metal oxides exhibited catalytic activity, nano composite, L‐ proline, enzymes, lewis acids,,‐ TMSCl, HOAc, Et 3 N, DBU, DMAP, chiral phosphoric acid organocatalyst, montmorillonite, mesoporous organic‐inorganic hybrid tin nanomaterial, nickel containing ionic liquid, cellulose sulphuric acid, BiBr 3 , La 2 O 3 /TFE, and etc. Various green methods that were reported for synthesis of DHP derivatives are solvent‐free reaction, microwave method, grindstone chemistry technique and Pd nanoparticles, Cu@BPMO−Ph‐IL, Co 3 O 4 ‐CNT, and ionic liquid functionalized silica modified Fe 3 O 4 nanoparticles …”

“…In addition, the literature survey reveals that the following different types of catalysts have been used in the synthesis of DHP derivatives, metal/metal oxides exhibited catalytic activity, [26][27][28][29] nano composite, [30] L-proline, [32][33] enzymes, [34][35] lewis acids, [31,[36][37][38] TMSCl, [39] HOAc, [40] Et 3 N, [41] DBU, [42] DMAP, [43] chiral phosphoric acid organocatalyst, [44] montmorillonite, [45][46][47] mesoporous organic-inorganic hybrid tin nanomaterial, [48] nickel containing ionic liquid, [49] cellulose sulphuric acid, [50] BiBr 3 , [51] La 2 O 3 /TFE, [52] and etc. Various green methods that were reported for synthesis of DHP derivatives are solvent-free reaction, [53][54]…”