“…3,5,9,[11][12][13][14] Although it is known that early daycare attendance is associated with an increased incidence and economic burden of AGE, it has also been suggested that early daycare may offer relative protection from AGE when children enter primary school. 8,15,16 The duration and magnitude of such opposite effects of early daycare exposure, however, remain unclear, and consequently the cumulative impact of daycare attendance on AGE disease burden during childhood also remains unclear.…”