Surveillance to estimate the burden of rotavirus gastroenteritis in children aged less than 3 years attending day care centers in Paris, France

Grimprel, E.; Garbarg‐Chenon, Antoine; Pirçon, Jean‐Yves; Curran, Desmond; Soriano‐Gabarró, Montse; Meyer, Nadia

doi:10.4161/hv.6.5.11021

Cited by 6 publications

(3 citation statements)

References 67 publications

(84 reference statements)

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“…We found an overall false-positive rate of 11.6% with the RotaStrip™ rapid test. A false- positive rate of 20% was reported in another recent study in France [14]. Indeed, it has been shown that the specificity of this type of rapid test can decrease substantially when the circulation of RV is low in the population under surveillance (personal communication, Miren Iturriza, EuroRotaNet and Health Protection Agency), highlighting the importance of confirming positive screening results using a reference assay.…”

Section: Incidence Of Rvgementioning

confidence: 90%

“…In addition to the direct protective effects of vaccination, RV vaccines may also be expected to reduce the number of cases among unvaccinated children [34]. As in other surveillance studies in Europe [1,9,11,14,32], disease burden was found to be the greatest among the youngest age groups, with even infants aged less than 3 months of age affected. As expected, almost all RVGE occurred between the months of December and May.…”

Section: Incidence Of Rvgementioning

confidence: 90%

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Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries

Díez-Domingo

Baldó

Patrzałek³

et al. 2010

Eur J Pediatr

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This observational, prospective study was undertaken to estimate the burden of rotavirus (RV) gastroenteritis (GE) leading to general practitioner (GP)/family paediatrician (FP) visits among children aged <5 years in Czech Republic, Germany, Italy, Poland, Spain and the UK. Children aged <5 years presenting with acute GE provided stool samples for rapid RV testing. RV+ samples were confirmed and typed by RT-PCR. Demographic and clinical data were collected for all RVGE episodes. Transmission patterns among other household children aged <5 years were also assessed. From November 2005 to May 2007, excluding data from the UK, 497/3,813 (13.0%) children aged <5 years presenting with acute GE to GP/FP and tested were RV+ by PCR. Most RVGE cases (69.1%) occurred in children aged <2 years, occurred between December and May (93.1%) and were moderate or severe by Vesikari score (92.9%). RV strain distribution varied between countries: G9P[8] was the most common type in Poland (54/76) and Spain (172/196), G1P[8] was predominant in the Czech Republic (56/64) and Italy (46/107), and G4P[8] and G1P[8] both prevailed in Germany (17/54 and 13/54, respectively). A total of 24/122 (19.7%) children aged <5 years resident in the same household as a PCR+ study participant also developed RVGE. Conclusion. This multinational epidemiological study in Europe shows that RV is easily transmitted among household children, with RVGE burden highest among children aged <2 years accessing primary healthcare for acute GE.

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Section: Incidence Of Rvgementioning

confidence: 90%

Section: Incidence Of Rvgementioning

confidence: 90%

Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries

Díez-Domingo

Baldó

Patrzałek³

et al. 2010

Eur J Pediatr

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“…Such estimates provide the baseline for studies of disease burden, cost of illness, risk factors, and intervention and help to assess the impact of gastroenteritis trends in the day care setting. Results from other studies help in this regard, although most pertain to well-known etiologic agents of mostly viral origin [5]–[7] during gastroenteritis outbreak investigations [8], [9], or to investigations in the setting of hospitals or general practice [2], [10]. In addition, these studies are often characterized by selective stool testing of symptomatic individuals, while a far larger number of gastrointestinal infections appear sporadically and possibly asymptomatically.…”

Section: Introductionmentioning

confidence: 99%

High Detection Rates of Enteropathogens in Asymptomatic Children Attending Day Care

Enserink

Scholts²,

Bruijning-Verhagen

et al. 2014

PLoS ONE

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BackgroundGastroenteritis morbidity is high among children under the age of four, especially amongst those who attend day care.ObjectiveTo determine the prevalence of a range of enteropathogens in the intestinal flora of children attending day care and to relate their occurrence with characteristics of the sampled child and the sampling season.MethodsWe performed three years of enteropathogen surveillance in a network of 29 child day care centers in the Netherlands. The centers were instructed to take one fecal sample from ten randomly chosen children each month, regardless of gastrointestinal symptoms at time of sampling. All samples were analyzed for the molecular detection of 16 enteropathogenic bacteria, parasites and viruses by real-time multiplex PCR.ResultsEnteropathogens were detected in 78.0% of the 5197 fecal samples. Of the total, 95.4% of samples were obtained from children who had no gastroenteritis symptoms at time of sampling. Bacterial enteropathogens were detected most often (most prevalent EPEC, 19.9%), followed by parasitic enteropathogens (most prevalent: D. fragilis, 22.1%) and viral enteropathogens (most prevalent: norovirus, 9.5%). 4.6% of samples related to children that experienced symptoms of gastroenteritis at time of sampling. Only rotavirus and norovirus were significantly associated with gastroenteritis among day care attendees.ConclusionsOur study indicates that asymptomatic infections with enteropathogens in day care attendees are not a rare event and that gastroenteritis caused by infections with these enteropathogens is only one expression of their presence.

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Impact des gastroentérites à Rotavirus chez les enfants de moins de cinq ans hospitalisés ou consultant en services d’urgences en France

Parez¹,

Mory²,

Pozzetto³

et al. 2012

Pathologie Biologie

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Surveillance to estimate the burden of rotavirus gastroenteritis in children aged less than 3 years attending day care centers in Paris, France

Cited by 6 publications

References 67 publications

Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries

Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries

High Detection Rates of Enteropathogens in Asymptomatic Children Attending Day Care

Impact des gastroentérites à Rotavirus chez les enfants de moins de cinq ans hospitalisés ou consultant en services d’urgences en France

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