Date seeds (<i>Phoenix dactylifera</i> L.) consumption as anti-inflammatory and immunostimulant: a systematic review

Saryono, Saryono; Dardjito, Endo; Proverawati, Atikah; Sumeru, Annas; Setiyani, Reni; Upoyo, Arif Setyo; Kamaludin, R.

doi:10.1088/1755-1315/250/1/012038

Cited by 14 publications

(11 citation statements)

References 20 publications

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“…The phenolic compounds present in date seeds exhibit an excellent source of natural antioxidants (El-Mergawi et al, 2016;Bouhlali et al, 2017), making this by-product a promising alternative to synthetic or semi-synthetic antioxidants. Moreover, increasing evidence indicates that date seeds possess anti-inflammatory (Saryono et al, 2020), immuno-stimulant (Saryono et al, 2019), and hepatoprotective properties (Khalid et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Phenolic fraction concentrate of Phoenix dactylifera L. seeds: A promising antioxidant and glucose regulator

Bikri¹,

Aboussaleh²,

Abuelezz³

et al. 2021

J Pharm Pharmacogn Res

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Context: The beneficial effects of natural polyphenolic compounds are increasingly emerging as powerful antioxidants and digestive boosters. Phoenix dactylifera seeds are recently identified as a healthy functional food with rich amounts of phenolic compounds. Aims: To analyzing the phenolic profile obtained from Moroccan variety of date seeds and evaluating the inhibitory capacity against digestive enzymes and the antioxidant potential of phenolic fraction concentrate (PFC) of date seeds as a promising antihyperglycemic agent. Methods: Lineweaver–Burk plot analysis was performed to evaluate PFC inhibitory effect against digestive enzyme activity in the presence of different doses of a substrate. Wistar rats were recruited to determine the acute and sub-acute oral toxicity of PFC. Finally, the optimal dose of PFC was selected and its effects on metabolic, hematological and biochemical parameters were determined. Results: High-performance liquid chromatography (HPLC) analysis revealed that PFC contains abundant amounts of phenolic acid: Caffeic acid, chlorogenic acid, 3,4-dihydroxybenzoic acid, p-hydroxybenzoic acid, and 3-hydroxybenzoic acid. PFC showed powerful antioxidant activity as determined by scavenging and reducing assays. PFC significantly inhibited alpha-amylase and alpha-glucosidase enzymes by 87.3% and 78.7%, respectively, via mixed manipulation of Km and Vmax. Acute toxicity examinations revealed PFC to be practically non-toxic with LD50 > 5000mg PFC/kg for both sexes of rats. The no-observed-adverse-effect-level (NOAEL) and lowest observed adverse effect level (LOAEL) for oral administration of PFC were 1000 and 2500 mg/kg for both sexes. Finally, the sub-acute study showed that a PFC dose of 50 mg/kg did not cause any changes in metabolic, biochemical and hematological parameters and was considered to be the optimal healthy dose for rats. Consequently, it induces improvement in glucose concentration in rats. Conclusions: The rational use of phenolic date seeds fraction presents powerful antioxidant and blood glucose regulating nutraceutical that could aid in diabetes mellitus management.

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Section: Introductionmentioning

confidence: 99%

Phenolic fraction concentrate of Phoenix dactylifera L. seeds: A promising antioxidant and glucose regulator

Bikri¹,

Aboussaleh²,

Abuelezz³

et al. 2021

J Pharm Pharmacogn Res

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“…22 (11) ©Annals of Tropical Medicine & Public Health S348 Saryono & Proverawati (2019): Hepatoprotective effect of date seeds December 2019 Vol. 22(11)…”

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confidence: 99%

Hepatoprotective effect of date seeds works through the antioxidant mechanism: a systematic review

Saryono¹,

Proverawati²

2019

ATMPH

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Background: Most toxic substances in the body are metabolized in the liver, so it's giving a hepatotoxic effect. This review aimed to examine the effects of consumption of date seeds in liver protection. Method: This research uses a systematic review design. Articles search is systematically carried out on the relevant publication databases such as Google Scholar, PubMed and DOAJ. The keywords used are "hepatoprotective", "date seed", and "date pits". Publication articles are limited between 2014 -2019. All applicable studies were evaluated based on titles and abstracts, then continued to the content. Results: we found 44 data sets of a total of 218 articles identified. Based on the inclusion criteria and critical assessment of the article, only 10 articles are in accordance with this review. Conclusion: Date seeds contain antioxidants that significantly increase antioxidant activity, reduce free radicals and improve liver enzymes and tissues.

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“…18 Considering the high amounts of polyphenols (hesperidin, quercetin, kaempferol, etc), phenolic acid (allergic, epicatechin, catechol, chlorogenic, etc), carotenoids, total dietary fibre (such as pectin, β-glucan, arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements in date seed, it has been considered as a functional food with multiple properties. [19][20][21][22][23] The maximum tolerated level of date seeds was reported to be at a dose of 0.5 g/kg/day. 24 Limited clinical trials and animal studies have reported modulating effects of date seed as a low-cost source, rich in antioxidant chemicals and prebiotic properties, on hyperglycaemia, 25 inflammation, 26 learning impairments, memory, 27 oxidative stress 28 and hyperlipidaemia.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…Recently, the date seed, an inedible part of date fruit and the main waste in the industry of date processing, has attracted the attention of many researchers 18. Considering the high amounts of polyphenols (hesperidin, quercetin, kaempferol, etc), phenolic acid (allergic, epicatechin, catechol, chlorogenic, etc), carotenoids, total dietary fibre (such as pectin, β-glucan, arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements in date seed, it has been considered as a functional food with multiple properties 19–23. The maximum tolerated level of date seeds was reported to be at a dose of 0.5 g/kg/day 24…”

Section: Introductionmentioning

confidence: 99%

Effect of date seed (Phoenix dactylifera) supplementation as functional food on cardiometabolic risk factors, metabolic endotoxaemia and mental health in patients with type 2 diabetes mellitus: a blinded randomised controlled trial protocol

2023

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IntroductionRecently, the improvement of chronic hyperglycaemia-related damage of type 2 diabetes mellitus (T2DM) through functional food consumption has attracted the attention of many clinicians. This study aims to determine the effectiveness of date seed powder (DSP) as a functional food (prebiotic) on the cardiometabolic risk factors, oxidative stress, anti-/inflammatory biomarkers, metabolic endotoxaemia (gut microbiota), adipokines, hypothalamic–pituitary–adrenal axis biomarkers, immune system, anthropometric indices and mental health in patients with T2DM.MethodsThis study protocol will be conducted as randomised, triple-blind, placebo-controlled trial with the inclusion of 48 patients with T2DM. The participants will be randomly assigned into two equal groups of intervention (n=24) and placebo (n=24) and receive 5 g/day of DSP or placebo for 8 weeks, respectively. At baseline and post-intervention, fasting blood samples will be collected to assess the serum levels of lipid profile, glycaemic indices, antioxidant and oxidative stress, anti-/inflammatory biomarkers, lipopolysaccharide, 8-hydroxy-guanine, adipokines, hypothalamic–pituitary–adrenal axis biomarkers, immune system and mental health. Data will be analysed using the SPSS software (V.16.0). To compare the quantitative variables, paired and unpaired Student’s t-tests and covariance analyses will be used.DiscussionIn this study, the potential effects of DSP on patients with T2DM will be evaluated for the first time. It is hoped that the results would increase the body of scientific knowledge about DSP supplementation on the cardiometabolic risk factors, oxidative stress, anti-/inflammatory biomarkers, metabolic endotoxaemia, adipokines, hypothalamic–pituitary–adrenal axis biomarkers, immune system, anthropometric indices and mental health in patients with T2DM.Ethics and disseminationThe study protocol was approved by the Ethical Committee of the Tabriz University of Medical Sciences, Tabriz, Iran (code: IR.TBZMED.REC.1400.752).Trial registration numberIranian Registry of Clinical Trials (www.irct.ir/IRCT20150205020965N10).

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Date seeds (Phoenix dactylifera L.) consumption as anti-inflammatory and immunostimulant: a systematic review

Cited by 14 publications

References 20 publications

Phenolic fraction concentrate of Phoenix dactylifera L. seeds: A promising antioxidant and glucose regulator

Phenolic fraction concentrate of Phoenix dactylifera L. seeds: A promising antioxidant and glucose regulator

Hepatoprotective effect of date seeds works through the antioxidant mechanism: a systematic review

Effect of date seed (Phoenix dactylifera) supplementation as functional food on cardiometabolic risk factors, metabolic endotoxaemia and mental health in patients with type 2 diabetes mellitus: a blinded randomised controlled trial protocol

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