Effect of date seed (<i>Phoenix dactylifera</i>) supplementation as functional food on cardiometabolic risk factors, metabolic endotoxaemia and mental health in patients with type 2 diabetes mellitus: a blinded randomised controlled trial protocol

Zadeh, Mehdi Mohammadi; Dehghan, Parvin; Eslami, Zahra

doi:10.1136/bmjopen-2022-066013

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…The protocol of the present trial has been previously published in the BMJ Open Journal [23]. Informed consent was obtained from all patients.…”

Section: Study Design and Proceduresmentioning

confidence: 99%

Effectiveness of date seed on glycemia and advanced glycation end-products in type 2 diabetes: a randomized placebo-controlled trial

Mohamadizadeh,

Dehghan,

Azizi-Soleiman

et al. 2024

Nutr. Diabetes

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Background Type 2 diabetes mellitus (T2DM) is a chronic medical condition affecting more than 95% of people with diabetes. Traditionally, some medicinal plants have been considered as an effective approach in management of T2DM. This trial evaluated the effects of date seed powder (DSP) on glycemia indices and oxidative stress in T2DM patients. Methods In this trail, 43 patients with T2DM were randomized to two groups: either 5 g/d of the DSP or placebo for 8 weeks. Levels of glycemic indices, lipolpolysaccharide (LPS), and soluble receptor for advanced glycation end products (s-RAGE), as well as other parameters associated with oxidative stress were assessed at baseline and after 8 weeks. Independent t-test and analysis of covariance (ANCOVA) were used for between-groups comparisons at baseline and the post-intervention phase, respectively. Results The results showed that supplementation with DSP significantly decreased HbA1c (−0.30 ± 0.48%), insulin (−1.70 ± 2.21 μU/ml), HOMA-IR (−1.05 ± 0.21), HOMA-B (−0.76 ± 21.21), lipopolysaccharide (LPS) (−3.68 ± 6.05 EU/mL), and pentosidine (118.99 ± 21.67 pg/mL) (P < 0.05, ANCOVA adjusted for baseline and confounding factors). On the other hand, DSP supplementation significantly increased total antioxidant capacity (TAC) (0.50 ± 0.26 mmol/L), superoxide dismutase (SOD) (0.69 ± 0.32 U/ml), and s-RAGE (240.13 ± 54.25 pg/mL) compared to the placebo group. FPG, hs-CRP, GPx, CML, and uric acid had no significant within- or between-group changes. Conclusion Supplementation of DSP could be considered an effective strategy to improve glycemic control and oxidative stress in T2DM patients (Registration ID at www.irct.ir: IRCT20150205020965N10).

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“…The protocol of the present trial has been previously published in the BMJ Open Journal [23]. Informed consent was obtained from all patients.…”

Section: Study Design and Proceduresmentioning

confidence: 99%

Effectiveness of date seed on glycemia and advanced glycation end-products in type 2 diabetes: a randomized placebo-controlled trial

Mohamadizadeh,

Dehghan,

Azizi-Soleiman

et al. 2024

Nutr. Diabetes

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Date seed (phoenix dactylifera) supplementation modulates oxidative DNA damage, lipid peroxidation, and cardiometabolic risk factors in type 2 diabetes: A triple-blinded randomized placebo-controlled trial

Karimi,

Dehghan,

Azizi-Soleiman

et al. 2024

Journal of Functional Foods

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Innovations in extractable compounds from date seeds: Farms to future

Alkatheri,

Alkatheeri,

Cheng

et al. 2024

AIMSAGRI

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<abstract> <p>Since ancient times, date fruit has been used as a staple food because of its high nutritional value and caloric content. With the development of food science and the application of modern instrumentation, we now know that date seeds contain large amounts of dietary fiber, phenols, polyphenols, amino acids, fatty acids, and many vitamins and minerals. Due to the presence of these functional food ingredients, date seeds are used in various applications, including foods such as bread, hot beverages, cosmetics such as hair and skin products, and as feed for culturing aquatic animals. Date seeds have been used in clinical applications, making use of their antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, and antimicrobial properties. There is now growing awareness of the value of date seeds, which were considered a waste product. In this review, we focused on explaining the major biochemical constituents of date seeds and developing these constituents for various applications. We also highlight the expected developments in date seed use for the future.</p> </abstract>

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Effect of date seed (Phoenix dactylifera) supplementation as functional food on cardiometabolic risk factors, metabolic endotoxaemia and mental health in patients with type 2 diabetes mellitus: a blinded randomised controlled trial protocol

Cited by 3 publications

References 59 publications

Effectiveness of date seed on glycemia and advanced glycation end-products in type 2 diabetes: a randomized placebo-controlled trial

Effectiveness of date seed on glycemia and advanced glycation end-products in type 2 diabetes: a randomized placebo-controlled trial

Date seed (phoenix dactylifera) supplementation modulates oxidative DNA damage, lipid peroxidation, and cardiometabolic risk factors in type 2 diabetes: A triple-blinded randomized placebo-controlled trial

Innovations in extractable compounds from date seeds: Farms to future

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