Das kolorektale Karzinom in Ägypten – Unterschiede zu anderen Ländern?

Abstract

Colorectal cancer is a disease of the elderly, and affects the younger population with an incidence of 2 to 6%.An increasing number of young colorectal carcinoma patients attending at Mansoura University Hospital, Mansoura, Egypt, was noted.This report represents our data of the last 5 years, and compares these results with those of other countries and those previously reported from Egypt.Data were collected retrospectively from the patient records of 400 consecutive patients who had colorectal cancer from January 1994 to March 1999 at Mansoura University Hospital. The maximum incidence was seen in the 5th and 6th decades (mean age was 45 years). A total of 29% of patients were younger than 30 years of age and 26% of them above the age of 60 years. The rectum was the most common site involved (68% of patients), followed by the sigmoid (colon/rectal ratio was 4 : 8.5). Two percent of cases were Dukes A Stage, 26% Dukes B, 31% Dukes C, and 41% Dukes D. The percentage of patients who underwent potentially curative resection was 66% (263 patients).Colorectal carcinoma in Egypt shares the epidemiological characteristics of developing countries which are higher incidence in younger patients and carcinoma of the rectum predominates

Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers: An Egyptian pilot study

“…Also, CRC was mainly moderately differentiated (56%), and more commonly and comparably presented in stages II and III (24% and 20%, respectively), and mostly localized (≥ 80%). This was in concordance with many studies [24,27,28], and Zeeneldin et al, except for the higher incidence of metastasis among young patients [18].…”

“…This agreed with another Egyptian studies [17,18,24]. On the contrary, Khafagy et al found the rectum the commonest site affected [27]. One third of cases (32%) had stricture, and 4% presented with mass, which was contrary to Gado et al [17].…”

Screening of BRCA1 Mutations Using C-terminal Antibody in Sporadic non Familial Colonic Carcinoma

“…The age of cases ranged from 30 years to 65 years with most of the cases above 40 years. This finding was almost similar to the results of the national cancer instituteEgypt (NCI) in the last statistical study in 2007 [13], and Elgharbeia registry in 2007 [14], which came in contrast to what was obtained by Khafagy et al [1] who noticed that most of the colonic carcinomas in Egypt and other developing countries occurred in young population with the mean age 45 years. In 2002, Abou Zeid et al [15] recorded that no age predilection could be observed and that more than one third of the affected patients were of the young population.…”

“…One million new patients are diagnosed and over half of these patients succumb to the disease each year. In Egypt, as in other developing countries, young age of incidence has been noticed in the last years in some registries [1]. According to the available registry most of the cancer colon cases are sporadic with the familial cases representing not more than 30% of the worldwide cases [2].…”

Ultrastaging of Rectal Cancer Based on Identification of Micrometastases in Sentinel Lymph Node

“…It makes up for about 70% of colorectal cancer patients in Egypt [18,19]. Stage is the strongest predictor of survival for patients with colorectal cancer.…”