Damage to lung epithelial cells and lining fluid antioxidant defense by humic acid

Qi, Shusen; Hartog, G.J.M. den; Bast, Aalt

doi:10.1016/j.etap.2008.02.007

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…It can lead to oxidative DNA and protein damage, increased permeability of cell membranes and possibly cell death, and also to a reduction in the activity of antioxidant enzymes. This mechanism may contribute to the pathogenesis of Blackfoot disease (peripheral vascular disease), Kashin-Beck disease (chronic osteoarthritic disorder), lung emphysema and fibrosis and other pathologies (Cheng et al 1999;Peng et al 1999;Gau et al 2001;Ho et al 2003;Qi et al 2008).…”

Section: Biomarker Of Oxidative Stressmentioning

confidence: 99%

“…On the other hand, HS, specifically HA, administered over a long period at high levels has been reported to induce damage in cells and tissues accompanied by an increase in oxidative stress and lipid peroxidation (Cheng et al 1999;Varanka et al 1999;Gau et al 2001;Ho et al 2003;Qi et al 2008). HS are natural materials with variable composition, which may explain the varying efficacy described in the literature.…”

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confidence: 99%

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Effects of sodium humate and zinc oxide used in prophylaxis of post-weaning diarrhoea on the health, oxidative stress status and fatty acid profile in weaned piglets

Trčková¹,

Lorencova²,

Babák³

et al. 2017

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to investigate the effects of sodium humate (HNa), applied to feed or drinking water as a partial substitution for pharmacological doses of ZnO, on clinical, biochemical and haematological indicators of health status, oxidative stress and the serum fatty acid (FA) profile in weaned piglets. Weaned piglets (32) were allocated into four groups: Control = basal diet containing 110 mg ZnO/kg; ZnO 2.5 = pharmacological dose of ZnO (2.5 g ZnO/kg); ZnO 1.7 + HNa (f ) = 1.7 g ZnO and 20.0 g HNa/kg; ZnO 1.7 + HNa (w) = 1.7 g ZnO/kg and drinking water with 0.2% HNa. All ZnO treatments resulted in good performance and clinical health of piglets in contrast to Control, which contained three diarrhoeic piglets. Increased triacylglycerols in the ZnO 2.5 and ZnO 1.7 + HNa (w) groups in comparison with Control suggested increased energy metabolism after treatments. Neither total cholesterol, nor HDL and LDL were affected by treatments. Piglets treated with ZnO and HNa had (ZnO 1.7 + HNa (w)) or tended to have (ZnO 1.7 + HNa (f )) lower urea in serum. Significantly (in ZnO 2.5 and ZnO 1.7 + HNa (f )) or non-significantly (ZnO 1.7 + HNa (w)) higher haematocrit and haemoglobin levels were detected in the blood of treated piglets. Long-term ZnO 2.5 treatment significantly increased serum 8-iso-PGF 2α , the most reliable biomarker of oxidative stress. Partial substitution of ZnO by HNa positively affected the oxidative status of piglets as evidenced by significant (ZnO 1.7 + HNa (w)) or non-significant (ZnO 1.7 + HNa (f )) declines in serum 8-iso-PGF 2α . ZnO 2.5 treatment significantly decreased saturated (SFA), monounsaturated (MUFA) and n-3 polyunsaturated FA (PUFA) and increased PUFA n-6 and n-6/n-3 ratios in serum compared to Control. The synthesis of some physiologically significant long-chain PUFA (LC-PUFA), namely n-6 dihomo-γ-linolenic acid and n-3 eicosapentaenoic, docosapentaenoic was negatively affected by ZnO 2.5 treatment. Both ZnO 1.7 + HNa (f )/(w) treatments significantly increased the proportion of SFA and PUFA n-3 and decreased PUFA n-6 and n-6/n-3 ratios in comparison with ZnO 2.5 and the effect was more considerable in ZnO 1.7 + HNa (w). Most individual PUFA n-3 and n-6 as well as the n-6/n-3 ratio in both treatments were similar to Control. The results indicate that the partial substitution of ZnO by HNa can benefit performance and health of weaned piglets to a similar extent as a high pharmacological dose of ZnO, whereas it can decrease the oxidative stress induced by prolonged over-supplementation of ZnO. Additionally, such a treatment can eliminate the unfavourable effect of high ZnO doses on the n-6/n-3 ratio and the proportion of some physiologically significant LC-PUFA in serum. Generally, it can be concluded that the effects of feed and water HNa supplementation are similar, but are more pronounced when HNa is applied to drinking water.Keywords: humic substances; pig; lipid metabolism; eicosanoids; serum biochemistry; haematology; performance; GC/MS; LC/MS-MS List of ab...

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Section: Biomarker Of Oxidative Stressmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of sodium humate and zinc oxide used in prophylaxis of post-weaning diarrhoea on the health, oxidative stress status and fatty acid profile in weaned piglets

Trčková¹,

Lorencova²,

Babák³

et al. 2017

Vet. Med. - Czech

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show abstract

“…It is one of the most crucial factors in the reversal and prevention of disease, as well as the maintenance of good health [4]. Studies have clearly shown that humic acid is the most powerful natural free radical scavenger and antioxidant in human body [5,6], it also finds that humic acid blocks or reduces the production of stress causing hormones, works with DNA and cellular division, stimulates microbial activity, has antimicrobial properties, bolsters the immune system, has anti-inflammatory, antiviral activity, liver effect, detoxifying properties, odor reduction, and miscellaneous properties [4]. Therefore, humic acid's greatest contribution to human health has been firmly recognized and will be treated as preventative dietary supplement.…”

Section: Introductionmentioning

confidence: 99%

Structural analysis and binding domain of albumin complexes with natural dietary supplement humic acid

Ding¹,

Diao²,

Yang³

et al. 2011

Journal of Luminescence

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“…They also regulate the speciation (De Paolis and Kukkonen, 1997 ; Khan and Schnitzer, 1972 ), bioavailability and toxicity of organic pollutants (Haitzer et al , 1998 ). They play an important role in stabilizing inorganic and other colloids (Tipping and Higgins, 1982 ;Tipping and Ohnstad, 1984 ) through surface sorption and charge and steric stabilization, and have also been shown to be toxic themselves (Bernacchi et al , 1996 ;Qi et al , 2008 ).…”

Section: Humic Substancesmentioning

confidence: 99%

Natural Colloids and Nanoparticles in Aquatic and Terrestrial Environments

Baalousha

Lead

Kammer

et al. 2009

Environmental and Human Health Impacts of Nanotechnology

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Damage to lung epithelial cells and lining fluid antioxidant defense by humic acid

Cited by 15 publications

References 40 publications

Effects of sodium humate and zinc oxide used in prophylaxis of post-weaning diarrhoea on the health, oxidative stress status and fatty acid profile in weaned piglets

Effects of sodium humate and zinc oxide used in prophylaxis of post-weaning diarrhoea on the health, oxidative stress status and fatty acid profile in weaned piglets

Structural analysis and binding domain of albumin complexes with natural dietary supplement humic acid

Natural Colloids and Nanoparticles in Aquatic and Terrestrial Environments

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