D1-like dopamine receptors downregulate Na+-K+-ATPase activity and increase cAMP production in the posterior gills of the blue crabCallinectes sapidus

Arnaldo, Francis B.; Villar, Van Anthony M.; Konkalmatt, Prasad; Owens, Shaun A.; Asico, Laureano D.; Jones, John E.; Yang, Jian; Lovett, Donald L.; Armando, Inés; José, Pedro A.; Concepción, Gisela P.

doi:10.1152/ajpregu.00555.2013

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…It's been shown that the activation of D1Rs inhibit the Na + K + -ATPase through PKA and PKC signaling pathways in striatum [34,35] (Fig. 1), it's also been shown that D1Rs are related with sodium homeostasis in the kidney [7,36], where D1Rs might play an important role in nephropathy that we will briefly discuss later.…”

Section: Aging and Disease • Volume 6 Number 5 October 2015 352mentioning

confidence: 99%

Dopamine Receptors and Neurodegeneration

Rangel‐Barajas¹,

Coronel²,

Florán³

2015

Aging and disease

187

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Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-like (D2, D3 and D4). All DA receptors are widely expressed in the central nervous system (CNS) and play an important role in not only in physiological conditions but also pathological scenarios. Abnormalities in the DAergic system and its receptors in the basal ganglia structures are the basis Parkinson's disease (PD), however DA also participates in other neurodegenerative disorders such as Huntington disease (HD) and multiple sclerosis (MS). Under pathological conditions reorganization of DAergic system has been observed and most of the times, those changes occur as a mechanism of compensation, but in some cases contributes to worsening the alterations. Here we review the changes that occur on DA transmission and DA receptors (DARs) at both levels expression and signals transduction pathways as a result of neurotoxicity, inflammation and in neurodegenerative processes. The better understanding of the role of DA receptors in neuropathological conditions is crucial for development of novel therapeutic approaches to treat alterations related to neurodegenerative diseases.

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Section: Aging and Disease • Volume 6 Number 5 October 2015 352mentioning

confidence: 99%

Dopamine Receptors and Neurodegeneration

Rangel‐Barajas¹,

Coronel²,

Florán³

2015

Aging and disease

187

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that cAMP and DAG, as second messengers, affect specific immunity by regulating PKA and PKC activities [21,22]. In the blue crab Callinectes sapidus, D1-like dopamine receptors increased the production of cAMP in the posterior gills [23].…”

Section: Discussionmentioning

confidence: 98%

Regulation Mechanism of Dopamine Receptor 1 in Low Temperature Response of Marsupenaeus japonicus

Ren,

Bian,

Shao

et al. 2023

IJMS

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Dopamine receptors (DARs) are important transmembrane receptors responsible for receiving extracellular signals in the DAR-mediated signaling pathway, and are involved in a variety of physiological functions. Herein, the D1 DAR gene from Marsupenaeus japonicus (MjDAD1) was identified and characterized. The protein encoded by MjDAD1 has the typical structure and functional domains of the G-protein coupled receptor family. MjDAD1 expression was significantly upregulated in the gills and hepatopancreas after low temperature stress. Moreover, double-stranded RNA-mediated silencing of MjDAD1 significantly changed the levels of protein kinases (PKA and PKC), second messengers (cyclic AMP (cAMP), cyclic cGMP, calmodulin, and diacyl glycerol), and G-protein effectors (adenylate cyclase and phospholipase C). Furthermore, MjDAD1 silencing increased the apoptosis rate of gill and hepatopancreas cells. Thus, following binding to their specific receptors, G-protein effectors are activated by MjDAD1, leading to DAD1-cAMP/PKA pathway-mediated regulation of caspase-dependent mitochondrial apoptosis. We suggest that MjDAD1 is indispensable for the environmental adaptation of M. japonicus.

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“…This regulatory mechanism according to Clark, Khan, and Baro (2008) and Therien and Blostein (2000) entails G-proteins that are coupled to D 1 receptors like protein kinase C and the associated pathways that promote the formation of cAMP. The mechanistic details of the role or involvement of protein kinases in the regulation of Na + /K + -ATPase involves the stimulation of adenyl cyclase activity by dopamine D 1 receptors to increase cAMP formation unlike D 2 -like receptors, to promote phosphorylation of Na + /K + -ATPase and consequent internalization or endocytosis and inactivation of the enzyme (Clark et al, 2008;Arnaldo et al, 2014). Endocytosis of the sodium pump as a means of inhibiting Na + /K + -ATPase other than direct phosphorylation has also been reported in Xenopus (Vasilets, Schmalzing, Madefessel, Hamse, & Schmalzing, 1990).…”

Section: Discussionmentioning

confidence: 99%

Tissue-specific changes in Ca2+-ATPase and Na+/K+-ATPase activities in freshwater African catfish Clarias gariepinus juvenile exposed to oxadiazon

Oluah

Mgbenka

Nwani

et al. 2020

JoBAZ

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Background: This study investigated the effect of sublethal concentrations (0.0, 0.3, 0.6, and 1.2 mg•L-1) of herbicide oxadiazon (ODZ) on the activities of Ca 2+-ATPase and Na + /K +-ATPase in juvenile Clarias gariepinus. Methods: One hundred eighty juveniles of Clarias gariepinus (mean weight 58.88 ± 1.24 g and mean length 22.34 ± 1.52 cm) were randomly divided into four groups and exposed to sublethal concentrations (0.00, 0.3, 0.6, and 1.2 mg•L-1 ODZ) for 21 days in a static renewal bioassay system in which the herbicide and water were replaced completely every day. The changes in Ca 2+-and Na + /K +-ATPase activities in the gill, kidney, liver, and heart of the fish were assayed on days 1, 7, 14, and 21. Result: The result showed significant alteration in the activity of these membrane-bound enzymes. There was duration and concentration-dependent significant (p < 0.05) increase in Ca 2+-ATPase activity in the treatment groups when compared with the control. The Na + /K +-ATPase activity was significantly (p < 0.05) inhibited in all the tissues when compared with control. The observed alterations in the activities of both Ca 2+-ATPase and Na + /K +-ATPase in this study may be indication of impaired ionic transport and imbalance in the fish which may trigger other biochemical, physiological, and even neurological consequences that may compromise several body functions. Conclusion: The alteration of the ATPase activities in C. gariepinus by ODZ is likely to affect the ATP usage and energy metabolism in the fish serious repercussions on Ca 2+ homeostasis, Na + /K + sodium pump, and Ca 2+ /Na + exchanger The results suggested that assay of the enzymes could be used as a biomarker of water pollution.

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D₁-like dopamine receptors downregulate Na⁺-K⁺-ATPase activity and increase cAMP production in the posterior gills of the blue crabCallinectes sapidus

Cited by 8 publications

References 52 publications

Dopamine Receptors and Neurodegeneration

Dopamine Receptors and Neurodegeneration

Regulation Mechanism of Dopamine Receptor 1 in Low Temperature Response of Marsupenaeus japonicus

Tissue-specific changes in Ca2+-ATPase and Na+/K+-ATPase activities in freshwater African catfish Clarias gariepinus juvenile exposed to oxadiazon

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