d-Glucosamine-based supramolecular hydrogels to improve wound healing

Yang, Zhimou; Liang, Guozheng; Ma, Manlung; Abbah, Sunny Akogwu; Lu, Wenqiang; Xu, Bing

doi:10.1039/b616563j

Cited by 216 publications

(242 citation statements)

References 43 publications

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“…However, direct cell injections have failed to deliver in a consistent manner in humans due to poor cell localisation [218][219][220][221], triggering an extensive investigation into the optimal cell carrier for tendon repair [1]. The ideal carrier system should prevent cell membrane rupture during the injection process; create increased tissue integration through fast in situ self-assembly; facilitate long-term cell survival and functionality maintenance; and allow spatiotemporal release of the cargo [222][223][224][225][226][227][228][229][230][231]. Preclinical data using either collagen [232] or fibrin [233] hydrogels have demonstrated improved mechanical properties, histological scores, tissue integration and restored functionality using TCs and various stem cell populations [234,235], however clinical use of injectable cell/hydrogel systems is still to be realised.…”

Section: Delivery Of Viable Cell Populationsmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

177

188

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Section: Delivery Of Viable Cell Populationsmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

177

188

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“…Another example of stereochemistry affecting gel properties appears in work using D-glucosamine-based supramolecular hydrogels as a biomaterial to promote wound healing. 45 Two different gels were produced, one with Nap-L-Phe-Dglucosamine (Gel I) as the gelator and the other with Nap-DPhe-D-glucosamine (Gel II). Both form stable hydrogels easily but the transmission electron micrograph (TEM) images of each show very different structures (shown in Figure 17).…”

Section: Gelsmentioning

confidence: 99%

Knot theory in modern chemistry

et al. 2016

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(2016) 'Knot theory in modern chemistry.', Chemical society reviews., 45 (23). pp. 6432-6448. Further information on publisher's website:https://doi.org/10.1039/C6CS00448BPublisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Knot theory is a branch of pure mathematics, but it is increasingly being applied in a variety of sciences. Knots appear in chemistry, not only in synthetic molecular design, but also in an array of materials and media, including some not traditionally associated with knots. Mathematics and chemistry can now be used synergistically to identify, characterise and create knots, as well as to understand and predict their physical properties. This tutorial r eview provides a brief introduction to the mathematics of knots and related topological concepts in the context of the chemical sciences. We then survey the broad range of applications of the theory to contemporary research in the field. Key Learning Points Some fundamentals of knot theory.  Knot theory and closely related ideas in topology can be applied to modern chemistry.  Knots can be formed in single molecules as well as in materials and biological fibres using a mixture of selfassembly, metal templating and optical manipulation. The inclusion of knots in molecular structures can alter chemical and physical properties.  Knots are surprisingly ubiquitous in the chemical sciences.

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“…For example, Yang et al fabricated supramolecular hydrogels based on d-Glucosamine (a natural compound in cartilage with significant role in wound healing) for wound healing applications. 238 The self-assembly of peptide-based nanofibers with EGF promoted wound healing in human tissue models. 80 Diverse self-assembly techniques 239 enable us to fabricate functional biomaterials as the wound dressings with tunable size, structure, and properties.…”

Section: Microfabrication Technologies To Provide Biochemical and Biomentioning

confidence: 99%

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Xiao

Ahadian

Radišić

2017

Tissue Engineering Part B: Reviews

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Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.

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d-Glucosamine-based supramolecular hydrogels to improve wound healing

Abstract: A simple supramolecular hydrogel based on D-glucosamine, a naturally occurring aminosaccharide, promises new biomaterials for applications such as wound healing.

Cited by 216 publications

References 43 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

Knot theory in modern chemistry

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

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