Cytotoxicity Screening of Plants of Genus &lt;i&gt;Piper&lt;/i&gt; in Breast Cancer Cell Lines

Sriwiriyajan, Somchai; Ninpesh, Thippawan; Sukpondma, Yaowapa; Nasomyon, Tapanawan; Graidist, Potchanapond

doi:10.4314/tjpr.v13i6.14

Cited by 62 publications

(50 citation statements)

References 16 publications

(18 reference statements)

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“…According to Zu et al [41] C. limon showed activity against PC3, A549 and MCF-7 cell lines. Reports for antitumor activity of P. nigrum are commonly related to the plant extracts [42] and not the EO; as to the best of our knowledge, this is the first report for cytotoxic properties of the EO. The toxicology profile of M. alternifolia oil is well-documented in review of Hammer [12] and according to in-vitro investigations of Liu et al, [43] this EO showed strong activity against PC-3, A549, and MCF-7 cell lines, as well as against HeLa, K564, Moult-4, Hep-G2 and HL-60.…”

Section: Cytotoxic Activitymentioning

confidence: 91%

Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils

Nikolić

Jovanović

Marković

et al. 2017

Journal of Pharmacy and Pharmacology

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Section: Cytotoxic Activitymentioning

confidence: 91%

Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils

Nikolić

Jovanović

Marković

et al. 2017

Journal of Pharmacy and Pharmacology

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“…Previously, we have shown that piperine itself had less effect against breast cancer cell lines than PFPE (15). Therefore, piperine was removed from the crude extract by recrystallization.…”

Section: Effect Of Pfpe On the Proliferation Of Breast Cancer Cell Linesmentioning

confidence: 99%

“…Moreover, PFPE exhibited higher cytotoxic effects on breast cancer cell lines than piperine (15). However, to date, there has been no study on the anticancer and cancer preventive effects of PFPE.…”

Section: Introductionmentioning

confidence: 98%

Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrum Extract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats

Sriwiriyajan

Tedasen

Lailerd

et al. 2016

Cancer Prevention Research

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Piper nigrum (P. nigrum) is commonly used in traditional medicine. This current study aimed to investigate the anticancer and cancer preventive activity of a piperine-free P. nigrum extract (PFPE) against breast cancer cells and N-nitrosomethylurea (NMU)-induced mammary tumorigenesis in rats. The cytotoxic effects and the mechanism of action were investigated in breast cancer cells using the MTT assay and Western blot analysis, respectively. An acute toxicity study was conducted according to the Organization for Economic Co-operation and Development guideline. Female Sprague-Dawley rats with NMU-induced mammary tumors were used in preventive and anticancer studies. The results showed that PFPE inhibited the growth of luminal-like breast cancer cells more so than the basallike ones by induction of apoptosis. In addition, PFPE exhibited greater selectivity against breast cancer cells than colorectal cancer, lung cancer, and neuroblastoma cells. In an acute toxicity study, a single oral administration of PFPE at a dose of 5,000 mg/kg body weight resulted in no mortality and morbidity during a 14-day observation period. For the cancer preventive study, the incidence of tumor-bearing rats was 10% to 20% in rats treated with PFPE. For the anticancer activity study, the growth rate of tumors in the presence of PFPE-treated groups was much slower when compared with the control and vehicle groups. The extract itself caused no changes to the biochemical and hematologic parameters when compared with the control and vehicle groups. In conclusion, PFPE had a low toxicity and a potent antitumor effect on mammary tumorigenesis in rats.Cancer Prev Res; 9(1); 74-82. Ó2015 AACR.

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“…The results of cell viability were presented in Table 2. According to the U.S. NCI plant screening program, a crude extract is generally considered to have in vitro cytotoxic activity with an IC50 value ≤20μg/mL [20]. Consequently, all the extracts demonstrated less toxicity on PC12 cells.…”

Section: Effects Of G Corniculatum Extracts On Viability Of Dpc12mentioning

confidence: 99%

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

Koçanci¹,

Aslım²

2017

International Journal of Secondary Metabolite

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Neurodegenerative diseases (NDs) are characterized by loss of neurons. NDs are associated with development of inflammation. Existing drugs against NDs only delay the progression; however, they do not provide a cure. The studies for the treatment of NDs focused on to discover natural products that have the potential of anti-inhibition and anti-radical properties. The Papaveraceae family members are important for the synthesis of pharmaceutically compounds such as flavonoids which act like anti-inflammatory drugs. In this study, methanol and water extracts of Glaucium corniculatum, a member of the Papaveraceae family, were analysed for flavonoid compounds. The effects of extracts on neuronal PC12 cells viability was determined. The anti-inflammatory effects of extracts were assessed by measuring the levels of IL-6 and IL-10 cytokines on hydrogen peroxide (H2O2)-stimulated PC12 cells. As a result of our studies, Rutin and Quercetin flavonoids have been found to be as major. The amount of Rutin was higher in methanol (45 μg/ml) than water (41 μg/ml). Quercetin was better extracted with methanol (12 μg/ml) than water (10 μg/ml). None of the tested extracts were cytotoxic even to PC12 cells. Both extracts showed an anti-inflammatory effect in a dose dependent manner. The water extract showed the maximum anti-inflammatory effect, with IL-6 secretion decreased 79 fold according to the H2O2 treated group and IL-10 secretion increased to 87 fold according to the control group. This study is an evidence that the Rutin and Quercetin flavonoids detected in G. corniculatum methanol and water extracts have a neuroprotective effect through anti-inflammation.

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Cytotoxicity Screening of Plants of Genus <i>Piper</i> in Breast Cancer Cell Lines

Cited by 62 publications

References 16 publications

Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils

Antimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oils

Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrum Extract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

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