Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine

Colombo, María Laura; Bugatti, Carlo; Mossa, Andrea; Pescalli, Nicoletta; Piazzoni, L.; Pezzoni, Gabriella; Menta, Ernesto; Spinelli, Silvano; Johnson, Francis; Gupta, Ramesh C.; Dasaradhi, Lakkaraju

doi:10.1016/s0014-827x(01)01121-1

Cited by 29 publications

(13 citation statements)

References 5 publications

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“…Recently, it was demonstrated that the chelidonine and alkaloidal rich extract (protoberberine and benzophenanthridine) of C. majus overcame the multidrug resistance of different cancer cells by apoptosis and cytotoxic effects of chemotherapeutics [66] . Colombo et al reported that the methanol extract of C. majus and the coptisine alkaloid showed strong cytotoxicity against human colon carcinoma [67] . However, other constituents including a protein-bound polysaccharide, CM-Ala and lectin isolated from C. majus were also suppressed the growth of cancer cells, in vitro [14,21] .…”

Section: Anticancermentioning

confidence: 99%

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Maji¹,

Banerji²

2015

Int. J. Herb. Med.

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Chelidonium majus L. (Papaveraceae) is a medicinal herb used in various traditional systems of medicine to treat ulcer, cancer, oral infection, liver disorders, chronic bronchitis, asthma, etc. Different parts of this plant contain numerous therapeutically important alkaloidal constituents such as chelidonine, chelerythrine, sanguinarine, berberine and so on. The plant and its active compounds exhibit a wide range of pharmacological activities. The plants has long history of therapeutic use in medicines without any toxic effect. Today it is one of the important components of some pharmaceutical preparations. Consumption of C. majus preparations possesses toxic effects on the liver although the effect becomes controversial with its hepatoprotective effect. Numerous active constituents of C. majus interact with various drug metabolizing enzymes that mimic possible interactions of this herb with the conventional drugs. This review provides detailed phytochemical, pharmacological and toxicological information of C. majus along with mechanisms of action of its various active compounds on different aspects of pharmacology. This review also highlights plausible drug interaction of its various active compounds and the future prospect of this herb.

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Section: Anticancermentioning

confidence: 99%

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Maji¹,

Banerji²

2015

Int. J. Herb. Med.

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“…The biological and anti-proliferative activities and pharmacological applications of celandine alkaloids have been extensively investigated in clinical studies [31,32]. Traditional methods for the evaluation of cytotoxic activity are based on the estimation of the ratio of live and dead cells using light microscopy or spectrophotometry.…”

Section: Cytotoxicity Testmentioning

confidence: 99%

Capillary electrophoresis with led-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L

Kulp

Bragina

Kogerman

et al. 2011

Journal of Chromatography A

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“…Among them are Baccharis dracunculifolia [20], Bidens pilosa [21], Chelidonium majus [22], Chenopodium ambrosioides [23], Citrus limon [24], Coffea arabica [25], Curcuma longa [26], C. zedoaria [27], Hypericum perforatum [28], Leonurus sibiricus [29], Malpighia glabra [30], Malva sylvestris [31], Maytenus ilicifolia [32], Mikania hirsutissima [33], Nicotiana tabacum [34], Oenothera biennis [35], Origanum majorana [36], Petiveria alliacea [37], Phyllanthus tenellus [38], Piper tuberculatum [39], Schinus molle [40], S. terebinthifolia [41], Senna obtusifolia [42], Solanum cernuum [43], Stevia rebaudiana [44], Taraxacum officinale [45], Tetradenia riparia [46], Tropaeolum majus [46], Urtica dioica [47], and Vernonia polyanthes [48] (Table 1). Similarly, the carcinogenesis preventive extract of Hibiscus rosa-sinensis [49] also afforded low to moderate values.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of native and exotic Brazilian plants for anticancer activity

et al. 2010

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Native and exotic Brazilian plants collected in the State of Minas Gerais were evaluated for their anticancer potential. Methanol extracts from leaves of 51 plant species were tested for cytotoxicity against four tumor cell lines: B16 (murine skin), HL-60 (human leukemia), MCF-7 (human breast), and HCT-8 (human colon). Plant extracts that exhibited IC(50) values less than 30 microg/ml against any tumor cell line were tested on sea urchin egg development and mouse erythrocytes. In addition, all extracts were evaluated for their general toxicity using the brine shrimp lethality assay. The most active extracts against the tumor cells were those obtained from Lantana fucata, Copaifera langsdorffii, and Momordica charantia. These three extracts inhibited sea urchin development from the first cleavage, but those from C. langsdorffii and M. charantia were very active against mouse erythrocytes. Only the L. fucata extract presented no hemolytic activity. Consequently, although the extracts of L. fucata, M. charantia, and C. langsdorffii could be useful in the development of new anticancer products, the first of these extracts is the most promising since it did not present unspecific toxicity, as suggested by negative results obtained with brine shrimp lethality and mouse erythrocytes assays.

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Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine

Cited by 29 publications

References 5 publications

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Capillary electrophoresis with led-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L

Evaluation of native and exotic Brazilian plants for anticancer activity

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