Chelidonium majus L. (Greater celandine) – A Review on its Phytochemical and Therapeutic Perspectives

Abstract

Chelidonium majus L. (Papaveraceae) is a medicinal herb used in various traditional systems of medicine to treat ulcer, cancer, oral infection, liver disorders, chronic bronchitis, asthma, etc. Different parts of this plant contain numerous therapeutically important alkaloidal constituents such as chelidonine, chelerythrine, sanguinarine, berberine and so on. The plant and its active compounds exhibit a wide range of pharmacological activities. The plants has long history of therapeutic use in medicines without any toxic effect. Today it is one of the important components of some pharmaceutical preparations. Consumption of C. majus preparations possesses toxic effects on the liver although the effect becomes controversial with its hepatoprotective effect. Numerous active constituents of C. majus interact with various drug metabolizing enzymes that mimic possible interactions of this herb with the conventional drugs. This review provides detailed phytochemical, pharmacological and toxicological information of C. majus along with mechanisms of action of its various active compounds on different aspects of pharmacology. This review also highlights plausible drug interaction of its various active compounds and the future prospect of this herb.

Transcriptome analysis ofChelidonium majuselaiosomes and seeds provide insights into fatty acid biosynthesis

“…1A) that is widely distributed in Europe and Asia. C. majus is rich in various types of isoquinoline alkaloids and is widely used against various diseases, such as ulcer, gastric cancer, oral infection, liver disorders, chronic bronchitis, asthma, and general pains, in European countries and Chinese traditional medicine (Arora & Sharma, 2013; Maji & Banerji, 2015). C. majus has attracted research attention not only for its medicinal value, but also for its well-known role in ant-dispersal (Fig.…”

Siberian plants: untapped repertoire of bioactive endosymbionts

“…It possess antidiarrheal, anti-inflammatory and antimicrobial activities along with adaptogenic, immunostimulating and nootropic effects (Popov et al 2005). Chelidonium majus L. is a medicinal herb which roots its traditional usages in wide range of pharmacological activities and used in treatment of oral infections, cancer, ulcers, bronchitis, asthma and many more (Maji & Banerji 2015). Studies have revealed that different parts of this plant contain wide range of phytocomponents such as chelidonine, berberine, sanguinarine and chelerythrine (Kokoska et al 2002).…”

Comparison of antioxidant activities of fractionated extracts from seedlings and herb of Chelidonium majus L. using DPPH, ABTS and FRAP methods

“…The our study is part of a trend of studies on the antioxidative properties of Ch. majus extracts or their fractions which suggest that a such antioxidant capacity may depend on flavonoid and/or total alkaloid contents [30][31][32][33]. The analysis of the current state of knowledge in the area of determination of the antioxidative potential of Ch.…”

“…The analysis of the current state of knowledge in the area of determination of the antioxidative potential of Ch. majus extract suggests that the most commonly used method of assessing the antioxidative capability was the DPPH method [26,[31][32][33], less frequently a FRAP method was used [30,31]. Moreover, the different solvent were performed and the most frequently alcoholic (methanolic, ethanolic) or aqueous extracts were analyzed.…”