Cytotoxicity and genotoxicity in human lung epithelial A549 cells caused by airborne volatile organic compounds emitted from pine wood and oriented strand boards

Gminski, Richard; Tang, Tiantong; Mersch-Sundermann, Volker

doi:10.1016/j.toxlet.2010.03.015

Cited by 69 publications

(40 citation statements)

References 45 publications

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“…In another study, it was determined that limonene, which is a monoterpene, did not exhibit genotoxic and mutagenic behaviour in male Big Blue rats (Turner et al 2001). Similarly, it was suggested that via the comet assay α-pinene did not affect the level of DNA damage in human lung adenocarcinoma/type II alveolar epithelial cells (A549) (Gminski et al 2010). In contrast to our findings, a previous study by Saverini et al (2012) demonstrated that (±)α-pinene and (+)β-pinene can cause damage to DNA in V79 Chinese hamster cells.…”

Section: Primary Rat Neuronsmentioning

confidence: 99%

Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

2013

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α-Pinene, an organic monoterpene, is found in essential oils of pine and coniferous trees. To date, although various biological activities of α-pinene have been demonstrated, its neurotoxicity has never been explored. Therefore in this study, we aimed to describe in vitro antiproliferative and/or cytotoxic properties by 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, genotoxic damage potentials by single cell gel electrophoresis, and oxidative effects by total antioxidant capacity (TAC) and total oxidative stress (TOS) analysis of α-pinene. Statistical analysis of MTT assay results indicated significant (p < 0.05) decreases of the cell proliferation rates in healthy neurons treated with α-pinene at only 400 mg/L, while significant decreases were observed in N2a cells at 100, 200 and 400 mg/L. On the other hand, the mean values of the total scores of cells showing DNA damage were not found significantly different from the control values on both cells. In addition, our results indicated that 10 and 25 mg/L of α-pinene treatment caused increases of TAC levels in primary rat neurons without any alterations of its level in N2a cells. However, α-pinene treatments at higher doses led to increases of TOS levels in both cell types. Overall our results suggest that α-pinene is of a limited therapeutic use as an anticancer agent.

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Section: Primary Rat Neuronsmentioning

confidence: 99%

Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

2013

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“…this alveolar swelling caused increased opacity and density of the tissue, hampering the normal functioning of the lungs of rats. the volatile nature of this compound further caused an increased irritation in the tissue and thus increased damage (22). the combined effect of the above damage is responsible for atypical alveolar hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Bioprotective efficacy of erucin against 7,12-dimethylbenz(α)anthracene-induced microstructural changes in male wistar rats

Mannan

Arora²,

Bhushan³

et al. 2017

TJPATH

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“…It is absorbed by the respiratory system, has neurotoxic properties and can cause depression in humans. It is classified as a mu- (Yang et al, 2005), 2,5-hexanedione (Kihaile et al, 2005), terpenes and aldehydes (Gminski et al, 2010), and resins from conifers (Söderberg et al, 1996).…”

Section: Toxicity and Ecotoxicity Of Selected Adhesive Components Toxmentioning

confidence: 99%

Adhesives based on formaldehyde – environmental problems

Wojtkowska¹,

Załęska-Radziwiłł²,

Tabernacka³

2017

bta

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Adhesives are substances that increase the surface adhesion of bonded items. Unfortunately, they also emit volatile organic compounds (VOCs) which negatively impact upon human and animal health. VOCs have carcinogenic and mutagenic properties and can cause migraines, irritation to the eyes, nasal passages, mouth, and lungs, and respiratory problems. Wastewater from adhesive production is characterized by high levels of pollutants and contains high concentrations of compounds including formaldehyde that are toxic to water biocenoses. Moreover, its purification causes many problems and requires the application of specific methods. This review presents data concerning the toxicity and ecotoxicity of selected adhesives components. VOC emission rates from adhesives and wooden construction elements with adhesives are also discussed and assessed. Current knowledge on the treatment methods for wastewater containing adhesive components is reviewed. Finally, the treatment and disposal methods for solid wooden waste containing adhesives are also analyzed and discussed.

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Cytotoxicity and genotoxicity in human lung epithelial A549 cells caused by airborne volatile organic compounds emitted from pine wood and oriented strand boards

Cited by 69 publications

References 45 publications

Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

Bioprotective efficacy of erucin against 7,12-dimethylbenz(α)anthracene-induced microstructural changes in male wistar rats

Adhesives based on formaldehyde – environmental problems

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