Cytotoxic Effects of CdSe Quantum Dots on Maturation of Mouse Oocytes, Fertilization, and Fetal Development

Hsieh, Ming-Shu; Shiao, Nion-Heng; Chan, Wen‐Hsiung

doi:10.3390/ijms10052122

Cited by 57 publications

(39 citation statements)

References 40 publications

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“…They also affect mouse oocyte development and were able to penetrate the UV-radiation and compromise skin barrier [188][189][190]. Titanium oxidecontaining sunscreen was used on the human skin to evaluate its toxicity [191].…”

Section: Effects On Organ Systemsmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Effects On Organ Systemsmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…Treatment of mouse oocytes with CdSe QD during in vitro maturation led to increased resorption of post-implantation embryos and decreased placental and fetal weights [Hsieh et al, 2009]. However, ZnS-coated CdSe QD did not affect development; therefore, surface modification of the core helped decrease the embryonic toxicity of the NP.…”

Section: Embryonic Toxicity Of Np In Animal Models: Mammalian Embryosmentioning

confidence: 99%

Embryonic Toxicity of Nanoparticles

Celá

Veselá

Matalová

et al. 2014

Cells Tissues Organs

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Applications of nanoparticles (NP) in medicine, industry and other branches of human activities undoubtedly contribute to technology development and well-being. However, as NP are very small units in a wide range of materials, there is a lack of information related to possible side effects potentially affecting the health of organisms. There is increasing experimental interest in the determination of environmental effects on humans exposed to NP. Most such experimental studies focus on adult populations or adult experimental animals. However, embryos can be more sensitive to pollutants and environmental impacts in some species. Therefore, some investigations dealing particularly with the effects of NP on embryonic development have appeared recently and this issue is becoming of great concern. The aim of this review is to summarize the knowledge on the effects of various nanomaterials on embryonic development. A comprehensive collection of significant experimental nanotoxicity data is presented, which also indicate how the toxic effect of NP can be mediated and modulated with respect to possible effective protection strategies.

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“…NP of smaller sizes penetrate the embryos easier and accumulate in higher quantities. The surface stabilization with SiO2, ZnS, PEG or other organic ligands (KingHeiden et al 2009;Hsieh et al 2009;Chu et al 2010;Yamashita et al 2011) also reduces the transplacental transfer. NP toxicity mechanisms have not been well established yet.…”

Section: Effects Of Nanoparticles On Embryogenesismentioning

confidence: 99%

“…Moreover, they depend on experimental conditions, the route of administration and NP type. However, recent studies imply that NP toxicity might be mediated by oxidative stress and inflammation (Shimizu et al 2009;Wang et al 2010), cell growth inhibition, enhanced apoptotic processes (Hsieh et al 2009;Guo et al 2011), necrosis (KingHeiden et al 2009), and/or DNA damage (Wang et al 2010).…”

Section: Effects Of Nanoparticles On Embryogenesismentioning

confidence: 99%

“…In the case of quantum dots (QD) the toxicity is related with the release of Cd 2+ ions and subsequent Cd 2+ induced effects (Karabanovas et al 2008;Hsieh et al 2009). However King-Heiden et al (2009) observed QD induced necrosis and yolk sac and tail malformation, which were not characteristic to Cd 2+ evoked effects, indicating that nanostructure exhibits new qualities that are not prominent in their components.…”

Section: Effects Of Nanoparticles On Embryogenesismentioning

confidence: 99%

See 1 more Smart Citation

Transport of Nanoparticles through the Placental Barrier

Kulvietis

Žalgevičienė

Didžiapetrienė

et al. 2011

Tohoku J. Exp. Med.

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Nanoparticles (NP) are organic or inorganic substances, the size of which ranges from 1 to 100 nm, and they possess specific properties which are different from those of the bulk materials in the macroscopic scale. In a recent decade, NP were widely applied in biomedicine as potential probes for imaging, drug-delivery systems and regenerative medicine. However, rapid development of nanotechnologies and their applications in clinical research have raised concerns about the adverse effects of NP on human health and environment. In the present review, special attention is paid to the fetal exposure to NP during the period of pregnancy. The ability to control the beneficial effects of NP and to avoid toxicity during treatment requires comprehensive knowledge about the distribution of NP in maternal body and possible penetration through the maternal-fetal barrier that might impair the embryogenesis. The initial in vivo and ex vivo studies imply that NP are able to cross the placental barrier, but the passage to the fetus depends on the size and the surface coating of NP as well as on the experimental model. The toxicity assays indicate that NP might induce adverse physiological effects and impede embryogenesis. The molecular transport mechanisms which are responsible for the transport of nanomaterials across the placental barrier are still poorly understood, and there is a high need for further studies in order to resolve the NP distribution patterns in the organism and to control the beneficial effects of NP applications during pregnancy without impeding the embryogenesis.

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Cytotoxic Effects of CdSe Quantum Dots on Maturation of Mouse Oocytes, Fertilization, and Fetal Development

Cited by 57 publications

References 40 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

Embryonic Toxicity of Nanoparticles

Transport of Nanoparticles through the Placental Barrier

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