Cytotoxic caged-polyprenylated xanthonoids and a xanthone from Garcinia cantleyana

Shadid, Khalid; Shaari, Khozirah; Abas, Faridah; Israf, Daud Ahmad; Hamzah, Ahmad Sazali; Syakroni, Normawati; SAHA, K; Lajis, Nordin Hj

doi:10.1016/j.phytochem.2007.05.024

Cited by 42 publications

(48 citation statements)

References 11 publications

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“…The investigation of leaves and trunk bark of G. cantleyana yielded five caged xanthones, deoxygaudichaudione A (40), gaudichaudione H (60), 7-hydroxyforbesione (103) and cantleyanones A-D (104-107) which exhibited cytotoxicity against MDA-MB-231, CaOV-3, MCF-7, and HeLa cancer cell lines with IC 50 values ranging from 0.22-17.17 μg/mL (Shadid et al, 2007) (Figure 6).…”

Section: Sources and Structure Diversity Of Prenylated Caged Xanthonesmentioning

confidence: 99%

Prenylated caged xanthones: Chemistry and biology

Anantachoke

Tuchinda

Kuhakarn

et al. 2011

Pharmaceutical Biology

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Section: Sources and Structure Diversity Of Prenylated Caged Xanthonesmentioning

confidence: 99%

Prenylated caged xanthones: Chemistry and biology

Anantachoke

Tuchinda

Kuhakarn

et al. 2011

Pharmaceutical Biology

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“…Based on this study, it can be concluded that these plants have cytotoxic properties, and although the plants are not usually used traditionally to treat cancer, this discovery is indeed invigorating for further studies to be undertaken on them. It is interesting to note we recently reported the isolation of potent cytotoxic xanthones from G. urophylla , G. penangiana and G. cantleyana (Shadid et al, 2007), which goes on to prove that the active plant extracts do contain prospective anticancer agents.…”

Section: Discussionmentioning

confidence: 90%

“…We have recently reported the cytotoxic constituents from Garcinia penangiana Pierre , Garcinia urophylla Scortech.ex King and Garcinia cantleyana T.C. Whitmore (Shadid et al, 2007). A number of new prenylated and caged prenylated xanthones have been found to exhibit strong cytotoxic activities and thus present good potential as new cytotoxic agents.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and nitric oxide inhibitory activities of methanol extracts ofGarciniaspecies

Jabit¹,

Wahyuni²,

Khalid³

et al. 2009

Pharmaceutical Biology

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“…Garcinia, one of the biggest genera of the family Guttiferae, has been found to be a rich source of xanthones, 7 biflavonoids, benzophenones 8 as well as triterpenoids. 9 Phenolic constituents from Garcinia species have been reported to possess various biological activities, including antibacterial, 10,11,12 cytotoxic 13,14 and pro-oxidant 15 activities. They also displayed inhibitory activity against α-glucosidase, glycation 16 and human immunodeficiency virus (HIV).…”

Section: Introductionmentioning

confidence: 99%

Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria

Jouda¹,

Tamokou²,

Mbazoa³

et al. 2016

Afr H. Sci.

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Background: The emergence of multiple-drug resistance bacteria has become a major threat and thus calls for an urgent need to search for new effective and safe anti-bacterial agents. Objectives: This study aims to evaluate the anticancer and antibacterial activities of secondary metabolites from Penicillium sp., an endophytic fungus associated with leaves of Garcinia nobilis. Methods: The culture filtrate from the fermentation of Penicillium sp. was extracted and analyzed by liquid chromatographymass spectrometry, and the major metabolites were isolated and identified by spectroscopic analyses and by comparison with published data. The antibacterial activity of the compounds was assessed by broth microdilution method while the anticancer activity was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results: The fractionation of the crude extract afforded penialidin A-C (1-3), citromycetin (4), p-hydroxyphenylglyoxalaldoxime (5) and brefelfin A (6). All of the compounds tested here showed antibacterial activity (MIC = 0.50 -128 µg/mL) against Gramnegative multi-drug resistance bacteria, Vibrio cholerae (causative agent of dreadful disease cholera) and Shigella flexneri (causative agent of shigellosis), as well as the significant anticancer activity (LC 50 = 0.88 -9.21 µg/mL) against HeLa cells. Conclusion:The results obtained indicate that compounds 1-6 showed good antibacterial and anticancer activities with no toxicity to human red blood cells and normal Vero cells.

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Cytotoxic caged-polyprenylated xanthonoids and a xanthone from Garcinia cantleyana

Cited by 42 publications

References 11 publications

Prenylated caged xanthones: Chemistry and biology

Prenylated caged xanthones: Chemistry and biology

Cytotoxic and nitric oxide inhibitory activities of methanol extracts ofGarciniaspecies

Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria

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