Cytotoxic Briarane Diterpenes from a Gorgonacean Briareum sp.

Diterpenes from gorgonian corals

“…42 Investigation of bioactive metabolites from a Briareum sp. collected in the area of Bonotsu, Kogoshima Prefecture, has led to the isolation of the briaranetype diterpenoids violides C-V (155)(156)(157)(158)(159)(160)(161)(162)(163)(164)(165)(166)(167)(168)(169)(170)(171)(172)(173)(174) and five new structures related to the violides (175-179), [43][44][45][46][47] their structures being elucidated by interpretation of spectroscopic and X-ray crystallographic data. Some of these metabolites exhibited moderate cytotoxicity against the growth of Vero and MDCK cells.…”

Marine natural products (1999)

“…A subsequent paper reported the isolation of violides J -M 675-678 from the same organism and the X-ray crystallographic structure determination of violide J 675. 487 Excavatolides F-M 679-686 and U-Z 687-692, some of which were cytotoxic, were isolated from a Taiwanese specimen of Briareum excavatum 488,489 while excavatolides N-T 693-699 were obtained from a Western Australian specimen of B. excavatum. 490 Having reached the end of the alphabet for the excavatolides, the next series of compounds from B. excavatum were named briaexcavatolides A-J 700-709 and the structure of briaexcavatolide B 701 was determined by X-ray crystallography.…”

Terpenoids from Octocorals of the Genus Pachyclavularia

“…They established the structures, including the relative configurations, of briaranes 42 – 45 by interpretation of spectroscopic data, and determined the absolute configurations of brianodins C ( 44 ) and D ( 45 ) by the modified Mosher’s method ( Figure 10 ). The 1,2-diol moiety at C-8 and C-17 in 43 – 45 is rarely found in briarane analogues [ 21 , 22 , 23 , 24 , 25 , 26 ].…”