Cytotoxic behavior of binuclear silver N-heterocyclic carbenes in HCT 116 cells and influence of substitution on cytotoxicity

Aher, Sainath Babaji; Dubey, Vinay; Muskawar, Prashant Narayan; Thenmozhi, Kathavarayan; Ghosh, Asit Ranjan; Bhagat, Pundlik Rambhau

doi:10.1007/s11164-017-2916-5

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…The NHC species are good electronic donors whereby Ag acts as an excellent accepter of electron density. The overall electronic exchange is the best example of a σ d donation from carbene C to the Ag centre and a π back‐donation from Ag to carbene C …”

Section: Resultsmentioning

confidence: 99%

“…In this paper, we report the influence of optical isomerism and various wingtip substituents in the structure of pyridine‐functionalized Pd NHC complexes on the antimicrobial activity and cytotoxicity against cancer cells. As the literature implies, the metal centre plays an important role in interacting with biological targets while lipophilicity is maintained at an optimum level by adjusting the side chain in the metal NHC complex …”

Section: Introductionmentioning

confidence: 99%

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Palladium complexes of bidentate pyridine N‐heterocyclic carbenes: Optical resolution, antimicrobial and cytotoxicity studies

Choo

Mah

Lee

et al. 2018

Applied Organom Chemis

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A series of bidentate pyridine‐functionalized palladium N‐heterocyclic carbene (Pd NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert‐butyl) have been synthesized and evaluated for their potential biomedical applications as antimicrobials and antiproliferative drug candidates. The obtained Pd NHC complexes were applied in a standard broth microdilution assay for determination of their antimicrobial activities against thirteen strains of pathogenic microorganisms. In addition to that, cytotoxic activities of the Pd NHC complexes were also evaluated against three human cancer cell lines, namely breast (MCF‐7), colon (HCT116) and oral (H103) cancer cells, using a standard MTT assay. Upon coordination to palladium, the Pd NHC complexes show significant antimicrobial activities with minimum inhibitory concentrations in the micromolar range, and they are cytotoxic to the tested carcinomas with IC50 ranging from 13 to 38 μM. Evidences for influence of both wingtip substituents and optical isomerism on the biological activities of the complexes have been found.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Palladium complexes of bidentate pyridine N‐heterocyclic carbenes: Optical resolution, antimicrobial and cytotoxicity studies

Choo

Mah

Lee

et al. 2018

Applied Organom Chemis

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“…The complexes 111 were obtained in a good yield in the range of 86-92 % (Scheme 26). [65] Şahin-Bölükbaşı and co-workers prepared novel silverÀ NHC complexes using benzimidazole and 2-methyl-2-propenyl chloride as starting material. Reaction of benzimidazole 21 and 112 in the presence of sodium hydride produced 113 which then treated with aryl halides to yield benzimidazolium salts 114 a-b.…”

Section: Silverà Nhc Complexesmentioning

confidence: 99%

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Nayak

Gaonkar

2021

ChemMedChem

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New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal‐based molecules. Among them, metal‐N‐heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal‐NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.

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Recent progress in silver(I)-, gold(I)/(III)- and palladium(II)-N-heterocyclic carbene complexes: A review towards biological perspectives

Hussaini

Haque

Razali

2019

Journal of Organometallic Chemistry

108

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Cytotoxic behavior of binuclear silver N-heterocyclic carbenes in HCT 116 cells and influence of substitution on cytotoxicity

Cited by 4 publications

References 37 publications

Palladium complexes of bidentate pyridine N‐heterocyclic carbenes: Optical resolution, antimicrobial and cytotoxicity studies

Palladium complexes of bidentate pyridine N‐heterocyclic carbenes: Optical resolution, antimicrobial and cytotoxicity studies

Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Recent progress in silver(I)-, gold(I)/(III)- and palladium(II)-N-heterocyclic carbene complexes: A review towards biological perspectives

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