Coinage Metal <i>N‐</i>Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Nayak, Swarnagowri; Gaonkar, Santosh L.

doi:10.1002/cmdc.202000836

Cited by 44 publications

(29 citation statements)

References 178 publications

(326 reference statements)

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“…Since the discovery of the antitumor properties of auranofin, several gold complexes including gold-NHC derivatives have been tested as potential anticancer drug candidates. [27][28][29] However, to the best of our knowledge, there are no reports addressing the antitumor properties of NHC-gold-amido complexes. Thus, with the aim of investigating the potential anti-…”

Section: Anticancer Activity Studiesmentioning

confidence: 99%

A simple synthetic entryway into new families of NHC–gold-amido complexes and their in vitro antitumor activity

et al. 2022

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Section: Anticancer Activity Studiesmentioning

confidence: 99%

A simple synthetic entryway into new families of NHC–gold-amido complexes and their in vitro antitumor activity

et al. 2022

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“…It is known that the transfer of carbene from silver to copper usually occurs under the the transmetalation conditions [34,87]. However, rare examples of the reverse transmetalation have been reported.…”

Section: "Reverse" Carbene Transfermentioning

confidence: 99%

Alternative Transformations of N-Heterocyclic Carbene Complexes of the Group 11 Metals in Transmetalation Reactions (A Review)

Mikhaylov

Балова

2021

Russ J Gen Chem

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The carbene transfer from N-heterocyclic carbene complexes of Group 11 metals (NHC-M C ) (especially silver and copper) to other metals is considered a convenient and universal, sometimes having no alternative, method for the synthesis of a wide range of important N-heterocyclic carbene complexes of transition metals. As the number of successful examples of transmetalation with the formation of the target product has increased, the data were accumulated on alternative or unexpected results of the interaction of NHC-M C complexes with compounds of other metals. This review considers the examples of NHC-M C reactions with compounds of other metals which proceed with a change in the metals oxidation state, conversion of (NHC)M C X into cationic homoleptic [(NHC) 2 M C ] + forms, transmetalation retaining the other metal in the coordination sphere of the product, or formation of heterometallic adducts preserving the M C -C carbene bond, rather than these occurring according to the standard reaction pathway. Unusual "reverse" carbene transfer reactions have been considered separately. The review material reveals a promising new synthetic potential of NHC-M C in the reactions with other metals and discusses the possible mechanisms and driving forces of such transformations. The most important aspects of the application of the obtained products, primarily in various catalytic processes, have been considered as well.

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“…Therefore, new antitumor drug studies have focused on the design of other metals as well as organic ligands. Metal complexes containing non‐platinum metals (e.g., ruthenium, titanium, gallium, iron, cobalt and gold) were studied in clinical phase or preclinical studies (Achar et al, 2017; Asif et al, 2016; Hackenberg, Lally, et al, 2012; Haque et al, 2018; Nayak & Gaonkar, 2020; Nolan, 2011; Patil, Deally, Gleeson, Hackenberg, et al, 2011; Silver, 2003). Because of the less harmful properties of coinage metals (especially Ag and Au) toward the human body, these metals have been found to be a special key for synthesis of new metallodrugs candidate.…”

Section: Introductionmentioning

confidence: 99%

Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

Şahin‐Bölükbaşı

Cantürk-Kılıçkaya

Kılıçkaya

2021

Drug Development Research

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Because of the continuous need for efficient therapeutic agents against various kinds of cancers and infectious diseases, the pharmaceutical industry has to find new candidates and strategies to develop novel and efficient drugs. They increasingly use computational tools in R&D stages for screening extensive sets of drug candidates before starting pre‐clinical and clinical trials. N‐Heterocyclic carbenes (NHCs) can be evaluated as good drug candidates because they offer both anti‐cancer and anti‐inflammatory features with their general low‐toxicity profiles. To date, different kinds of NHCs (Cu, Co, Ni, Au, Ag, Ru, etc.) have been synthesized and their therapeutic uses has been shown. Here, we have reviewed the recent studies focused on Ag(I)‐NHC complexes and their anti‐cancer activities. Also, existing examples of the usage of density functional theory and structure–activity relationship have been evaluated.

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Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications

Cited by 44 publications

References 178 publications

A simple synthetic entryway into new families of NHC–gold-amido complexes and their in vitro antitumor activity

A simple synthetic entryway into new families of NHC–gold-amido complexes and their in vitro antitumor activity

Alternative Transformations of N-Heterocyclic Carbene Complexes of the Group 11 Metals in Transmetalation Reactions (A Review)

Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

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