Recent progress in silver(I)-, gold(I)/(III)- and palladium(II)-N-heterocyclic carbene complexes: A review towards biological perspectives

Synthesis and structural characterization of benzyl-functionalized N-heterocyclic carbene platinum complexes: Dramatic substituent effect on anti-cancer activity

“…The NHC-platinum bond lengths are 1.974(3) Å and 1.969 (6) (3); Pt(1)-N(4), 2.089(3); Pt(1)-I(1), 2.5887(3); Pt(1)-I(2), 2.5979(3); N(2)-C(1)-N(1), 105.2(3); N(4)-Pt(1)-I(1), 89.70 (7); N(4)-Pt(1)-I(2), 90.69 (7); I(1)-Pt(1)-I(2), 178.436(9); C(1)-Pt(1)N(4), 178.85(12); C(12)-N(4)-C(1)-N(2), -43.0(3); I(1)-I(2)-C(1)-N(4), -1.9(4). (6); Pt(1)-N(3), 2.089(5); Pt(1)-I(1), 2.5936 (6); Pt(1)-I(2), 2.5863 (6); N(1)-C(1)-N(2), 104.5(5); N(3)-Pt(1)-C(1), 177.8(3); I(1)-Pt(1)-I(2), 179.46(2); C(26)-N(3)-C(1)-N(1), 24.30(10); I(1)-I(2)-C(1)-N(3), 1.15 (11).…”

“…Soon after, Marinetti [3b] and others [9,10,11] investigated the effect on cell activity of several Nheterocyclic carbene platinum complexes. These studies established that both the nature of the NHC backbone and the amine that is trans-coordinated to the carbene might influence the cytotoxic activity of the corresponding Pt complex.…”

Coinage metal complexes of N‐heterocyclic carbene bearing nitrile functionalization: Synthesis and photophysical properties

“…The use of carbenes as ligands in transition metal complexes has been extensively explored in the past few decades, due to their marked stability and strong electron‐donating capacity compared to their phosphine ligand counterparts . Carbene ligands, in particular, N‐heterocyclic carbene (NHC)‐type ligands that were isolated by Arduengo and co‐workers, are known to be the first example of free and stable NHC motifs in the history of carbene ligands . The coordination of NHCs to transition metals arises from their strong σ‐donor and weak π‐acceptor properties, thus giving rapid advances and widespread interest in the fields of organometallic, coordination and inorganic chemistry .…”

A Supramolecular Interaction of a Ruthenium Complex With Calf-Thymus DNA: A Ligand Binding Approach by NMR Spectroscopy

“…A strategy used to design new chemotherapeutics candidates and improve its anti-tumoral activity, consists on the complexation of some metallic centers, among them, silver (I) (Ali et al, 2013; Engelbrecht et al, 2018; Hussaini et al, 2019), gold (I)/(III) (Yeo et al, 2018; Dabiri et al, 2019; Hussaini et al, 2019), copper (II) (Khan et al, 2017; Zhang et al, 2018; Chen et al, 2019), and platinum (II) (Hua et al, 2019; Hussaini et al, 2019; Makovec, 2019) with a wide-range of ligands and also with natural molecules that already demonstrate some anti-cancer features, such as quinoline, flavones, and naphthoquinones (Kosmider and Osiecka, 2004; Lu et al, 2016; Oliveira et al, 2017a; Wang et al, 2018; Grandis et al, 2019). In this scenario, ruthenium takes special interests due to the possibility to reach several different metallic-arrangements, supplying distinct reactivities and applications (Oliveira et al, 2017b; Hussaini et al, 2019; Roy et al, 2019).…”