Cytotoxic and antimicrobial activities of new phytosteroids from the leaves of Anonidium mannii (Oliv.) Engl. & Diels (Annonaceae)

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

“…[62] The observed antiproliferative properties of the tested extract can be attributed to the ability of phytochemicals present in the extract to impede cell-cycle progression, induce apoptosis, and disrupt the structural integrity of the cancer cell lines. [46] The significant antiproliferative activity observed in this study confirms the efficacy and potential of S. viscosa as a promising candidate for cancer management. This plant has the potential to serve as a valuable source of therapeutic agents with anticancer activity.…”

“…Phenolic compounds are known for their chelating properties, which inhibit bacterial growth. [46] The antimicrobial properties of the phytochemical constituents present in S. viscosa extracts may involve different modes of action. Phenolic compounds can directly disrupt the bacterial cell membrane, leading to inhibition of cell metabolism and leakage of cellular content.…”

Comparative evaluation of antiplasmodial and cytotoxic Activities of Anonidium mannii (Oliv) Engl. et Diels leaves, trunk and roots

“…In order to contribute to the enhancement of floristic biodiversity in general and in particular to the study of Anonidium mannii (Oliv) Engl. and Diels, a medicinal plant from Cameroon, we directed our research to the evaluation of the antiplasmodial activity of the different parts of this plant, motivated on the one hand by its use in traditional medicine for the treatment of malaria [9,10] . On the other hand, a literature review revealed few studies antiplasmodial and cytotoxic activity of A. mannii leaves, twigs and stem bark [9][10][11] .…”

“…and Diels, a medicinal plant from Cameroon, we directed our research to the evaluation of the antiplasmodial activity of the different parts of this plant, motivated on the one hand by its use in traditional medicine for the treatment of malaria [9,10] . On the other hand, a literature review revealed few studies antiplasmodial and cytotoxic activity of A. mannii leaves, twigs and stem bark [9][10][11] . However, the phytochemical study, the antiprotozoal activity of the leaves and stem bark [10,11] , the antimycobacterial activities of the leaves and twigs [12] ; the antioxidant, cytotoxic and antibacterial activities of the leaves [13,14] ; phytochemical screening and antioxidant activity in all parts (root wood, leaves, trunk bark, trunk wood and root bark) [15] ; the toxicity (acute and subacute) and the evaluation of the antimicrobial activities of the leaves and stem bark (G, Ekounè et al, 2022) [16] , as well as the antibacterial activity of the methanol extract of the leaves and roots of A. mannii [17] have already been studied.…”

“…On the other hand, a literature review revealed few studies antiplasmodial and cytotoxic activity of A. mannii leaves, twigs and stem bark [9][10][11] . However, the phytochemical study, the antiprotozoal activity of the leaves and stem bark [10,11] , the antimycobacterial activities of the leaves and twigs [12] ; the antioxidant, cytotoxic and antibacterial activities of the leaves [13,14] ; phytochemical screening and antioxidant activity in all parts (root wood, leaves, trunk bark, trunk wood and root bark) [15] ; the toxicity (acute and subacute) and the evaluation of the antimicrobial activities of the leaves and stem bark (G, Ekounè et al, 2022) [16] , as well as the antibacterial activity of the methanol extract of the leaves and roots of A. mannii [17] have already been studied. Consequently, the aim of this work was to evaluate and compare the antiplasmodial activity and study the cytotoxicity of the methanolic extract of Anonidium mannii leaves, trunk wood, stem bark, root wood, root bark in order to determine the parts displaying the best activity.…”