Cytotoxic and anti-oxidant biphenyl derivatives from the leaves and twigs of Garcinia multiflora

Tian, Dongsong; Gu, Wei; Wang, Liping; Huang, Liejun; Rao, Qing; Huang, Tao; Fu, Yan-Hui; Zhang, Jianxin; Yuan, Chun‐Mao; Hao, Xiao‐Jiang

doi:10.1016/j.phytol.2016.12.021

Cited by 13 publications

(11 citation statements)

References 13 publications

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“…Many biphenyls were reported to have cytotoxic activity, anti‐inflammatory activity, antioxidative activity, antiviral activity, and antibacterial activity . In these references, cytotoxicity of this kind of compounds was the most frequently reported.…”

Section: Resultsmentioning

confidence: 99%

New Constituents from the Low Polar Fraction of the Fruits of Crataegus dahurica and Their Anti‐Inflammatory Activity in RAW264.7 Cells

Wang

Gao

Chen

et al. 2020

Chemistry & Biodiversity

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The fruit of Crataegus dahurica Koehne was used to treat the disease of infantile indigestion and dyspepsia as an ethnic medicine and food. As a continuous work on finding the active constituents from the edible herbs, four new biphenyl derivatives (1–4), together with two known compounds (5 and 6), were obtained from the petroleum ether fraction of the fruits of C. dahurica. Their structures were determined by the extensive 1D and 2D NMR spectra and HR‐MS spectrometry. Furthermore, the anti‐inflammatory activities of all the isolated compounds were investigated, in which compound 4 showed moderately inhibitory effects on NO production in RAW264.7 cells without inducing cytotoxicity.

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Section: Resultsmentioning

confidence: 99%

New Constituents from the Low Polar Fraction of the Fruits of Crataegus dahurica and Their Anti‐Inflammatory Activity in RAW264.7 Cells

Wang

Gao

Chen

et al. 2020

Chemistry & Biodiversity

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“…Beberapa tanaman dari genus Garcinia telah diteliti secara ilmiah dan diketahui mempunyai aktivitas sebagai agen antioksidan, antara lain G. livingstonei, G. multiflora, G. madruno, G. malaccensis, dan G. preussii. Adapun senyawa aktif yang berperan dalam aktivitas antioksidan dari masing-masing tanaman tersebut yakni benzophenone derivative, biphenyl derivatives, biflavonoid, α-mangostin, dan garciniagifolone (11)(12)(13)(14)(15).…”

Section: Pendahuluanunclassified

AKTIVITAS ANTIOKSIDAN FRAKSI DARI DAUN Garcinia kydia Roxburgh

Martha¹,

Elya

Hanafi

2020

MFF

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Garcinia kydia Roxburgh merupakan salah satu spesies dari genus garcinia, yang secara khusus belum banyak diketahui aktivitas senyawa bioaktif, namun pada penelitian sebelumnya terbukti berpotensi sebagai agen penghambat α-glukosidase. Pada penelitian ini, akan dilakukan investigasi aktivitas antioksidan terhadap berbagai fraksi yang diperoleh dari daun G. kydia Roxb. Metode penelitian dilakukan dengan menentukan aktivitas antioksidan melalui analisis in-vitro menggunakan microplete reader dengan metode radical scavenging (Metode DPPH) dan ferric reducing antioxidant power (Metode FRAP). Hasil menunjukkan bahwa fraksi yang paling aktif dari ekstrak etil asetat adalah FEA8 (DPPH) dan FEA7 (FRAP), sedangkan fraksi paling aktif dari ekstrak metanol adalah FMT4 (DPPH) dan FMT6 (FRAP). Aktivitas antioksidan tertinggi di antara empat fraksi adalah FEA7 dan FEA8. Aktivitas fraksi FEA7 dan FEA8 ditentukan oleh nilai EC50, sehingga diperoleh masing-masing 9,73 dan 9,26 μg/mL (DPPH); 10,28 dan 13,94 μg/mL (FRAP). Garcinia kydia Roxb. berpotensi sebagai agen antioksidan dengan mekanisme yang berbeda. Sehingga hasil penelitian terkait terdapatnya potensi antioksidan tersebut dapat memberikan alternatif terapi diabetes yang disertai komplikasi stres oksidatif.

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“…The EtOAc extract (67.5 g) was chromatographed on a silica gel column using step gradient elution of CH 2 Cl 2 -MeOH (0-100%, v/v) to yield eleven fractions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Fraction 2 (5.6 g) was further separated into seven subfractions by Sephadex LH-20 eluting with MeOH-CH 2 Cl 2 (1:1, v/v).…”

Section: Fermentation Extraction and Isolationmentioning

confidence: 99%

“…Endophytic fungi are capable to produce chemical constituents of the host plant [2], and even novel bioactive natural products [3]. Garcinia multiflora, which widely distributed in the south of China, is a traditional Chinese Medicine to reduce inflammation [4]. The identified chemical constituents of G. multiflora included biphenyls, polycyclic polyprenylated acylphloroglucinols, polyprenylated phloroglucinols, xanthones, bioflavonoids, and benzophenones [5].…”

mentioning

confidence: 99%

Kojic Acid Derivatives and Sesquiterpenes from the Aspergillus flavus GZWMJZ-288, A Fungal Endophyte of Garcinia multiflora

Wang

Gong

et al. 2018

Natural Product Communications

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One new kojic acid dimer, dikojiacid A (1), one new naturally occurring kojic acid dimer, dikojiacid B (2), one new sesquiterpene, 12-hydroxy-8-ene-3oxodrimenol (6), as well as three known kojic acid derivatives (3-5) and five sesquiterpenes (7-11) were isolated from a solid culture of the endophytic fungus Aspergillus flavus GZWMJZ-288 with Garcinia multiflora. The structures of the new compounds were determined on the basis of spectroscopic data and ECD calculation. This is the first report for the natural kojic acid dimers by which Aspergillus flavus GZWMJZ-288 avoids the injury from acetaldehyde.

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Cytotoxic and anti-oxidant biphenyl derivatives from the leaves and twigs of Garcinia multiflora

Cited by 13 publications

References 13 publications

New Constituents from the Low Polar Fraction of the Fruits of Crataegus dahurica and Their Anti‐Inflammatory Activity in RAW264.7 Cells

New Constituents from the Low Polar Fraction of the Fruits of Crataegus dahurica and Their Anti‐Inflammatory Activity in RAW264.7 Cells

AKTIVITAS ANTIOKSIDAN FRAKSI DARI DAUN Garcinia kydia Roxburgh

Kojic Acid Derivatives and Sesquiterpenes from the Aspergillus flavus GZWMJZ-288, A Fungal Endophyte of Garcinia multiflora

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