New Constituents from the Low Polar Fraction of the Fruits of <i>Crataegus dahurica</i> and Their Anti‐Inflammatory Activity in RAW264.7 Cells

Wang, Bobo; Gao, Yang; Chen, Liya; Zhang, Changlong; Zhang, Xiaoqing; Zhang, Hailong

doi:10.1002/cbdv.201900609

Cited by 3 publications

(2 citation statements)

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“…The whole HFE also inhibited ROS formation and mRNA production of protein kinase (MAPK)/activator protein‐1 (AP‐1), NF‐κB, and lipopolysaccharide (LPS)‐stimulated keratinocytes nuclear factor levels of activated T cells (NFAT) and interleukins in keratinocytes in a dose‐dependent manner (Nguyen et al., 2021). Moreover, four new biphenyl derivatives (1–4) as well as two known compounds (5 and 6) extracted from the whole hawthorn fruit also showed anti‐inflammatory activities in mouse mononuclear macrophage leukemia cells (RAW264.7 cells) (Wang et al., 2020).…”

Section: Bioactivities Based On In Vitro and In Vivo Studiesmentioning

confidence: 99%

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

Ma,

Yang,

et al. 2024

Food Frontiers

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The discovery of new natural sources has brought increased attention to the development of functional foods. The hawthorn (Crataegus pinnatifida Bge.) fruit is an underutilized fruit due to its benefits for human health and good taste. It contains a variety of bioactive ingredients, contributing to its multiple beneficial functions and applications. This review summarized and discussed the main bioactive ingredients, beneficial functions based on in vitro, in vivo, and human studies, and different applications of the hawthorn fruit according to the updated literature in the past 3 years. Hawthorn berries contain phenolic acids, flavonoids, proanthocyanidins, pectin, and many other bioactive components, which have a variety of beneficial functions, such as antioxidant, anti‐inflammatory, antibacterial, antidiabetic, intestinal protection, cardiovascular protection, hepatoprotection, anti‐cancer, and neuroprotection. Its potential molecular mechanism and different food‐related applications such as hawthorn wine and antioxidant drink are discussed in detail in this review. Additionally, hawthorn berries are shown to be safe when consumed within the proper dosage. Collectively, this updated review indicates that the hawthorn fruit can be a new dietary source of bioactive ingredients with multiple beneficial functions and can be affordably developed into functional and medicinal foods for the prevention and management of certain chronic diseases.

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Section: Bioactivities Based On In Vitro and In Vivo Studiesmentioning

confidence: 99%

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

Ma,

Yang,

et al. 2024

Food Frontiers

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“…219 (2 E )-[2-(Biphenyl)imidazo[1,2- a ]pyrimidine-3-yl](4-nitrophenyl)-prop-2-en-1-one, 2-(biphenyl)imidazo[1,2- a ]pyrimidine-3-carbaldehyde and 6-[2-(biphenyl)imidazo[1,2- a ]pyrimidine-3-yl]-4-nitro pyrimidine-2(1 H )-one exhibit promising antitumor activity by reducing the level of liver function enzyme near the normal level after damaged by CCl 4 . 220 Whereby, trimethoxy-[1,1′-biphenyl]-2-ol (VI) displays anti-inflammatory activity 221 (Fig. 4).…”

Section: Patentsmentioning

confidence: 99%

A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects

et al. 2023

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Biphenyls and dibenzofurans of the rosaceous subtribe Malinae and their role as phytoalexins

Busnena,

Beerhues,

Liu

2023

Planta

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Main conclusion Biphenyl and dibenzofuran phytoalexins are differentially distributed among species of the rosaceous subtribe Malinae, which includes apple and pear, and exhibit varying inhibitory activity against phytopathogenic microorganisms. Abstract Biphenyls and dibenzofurans are specialized metabolites, which are formed in species of the rosaceous subtribe Malinae upon elicitation by biotic and abiotic inducers. The subtribe Malinae (previously Pyrinae) comprises approximately 1000 species, which include economically important fruit trees such as apple and pear. The present review summarizes the current status of knowledge of biphenyls and dibenzofurans in the Malinae, mainly focusing on their role as phytoalexins. To date, 46 biphenyls and 41 dibenzofurans have been detected in 44 Malinae species. Structurally, 54 simple molecules, 23 glycosidic compounds and 10 miscellaneous structures were identified. Functionally, 21 biphenyls and 21 dibenzofurans were demonstrated to be phytoalexins. Furthermore, their distribution in species of the Malinae, inhibitory activities against phytopathogens, and structure–activity relationships were studied. The most widely distributed phytoalexins of the Malinae are the three biphenyls aucuparin (3), 2ʹ-methoxyaucuparin (7), and 4ʹ-methoxyaucuparin (9) and the three dibenzofurans α-cotonefuran (47), γ-cotonefuran (49), and eriobofuran (53). The formation of biphenyl and dibenzofuran phytoalexins appears to be an essential defense weapon of the Malinae against various stresses. Manipulating phytoalexin formation may enhance the disease resistance in economically important fruit trees. However, this approach requires an extensive understanding of how the compounds are formed. Although the biosynthesis of biphenyls was partially elucidated, formation of dibenzofurans remains largely unclear. Thus, further efforts have to be made to gain deeper insight into the distribution, function, and metabolism of biphenyls and dibenzofurans in the Malinae.

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New Constituents from the Low Polar Fraction of the Fruits of Crataegus dahurica and Their Anti‐Inflammatory Activity in RAW264.7 Cells

Cited by 3 publications

References 24 publications

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions

A fruitful century for the scalable synthesis and reactions of biphenyl derivatives: applications and biological aspects

Biphenyls and dibenzofurans of the rosaceous subtribe Malinae and their role as phytoalexins

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