Cytotoxic and Anti-HIV Principles from the Rhizomes of Begonia nantoensis

Wu, Pei Lin; Lin, Fu Wen; Wu, Tian Shung; Kuoh, Chang Sheng; Lee, Kuo Hsiung̀; Lee, Shiow Ju

doi:10.1248/cpb.52.345

Cited by 79 publications

(34 citation statements)

References 38 publications

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“…The aqueous solution was partitioned with CHCl 3 and EtOAc, successively. The obtained CHCl 3 and EtOAc soluble fractions were individually separated by silica gel column chromatography to afford fifty-six compounds, including five new compounds: hibicuslide A (1), hibicuslide B (2), hibicuslide C (3), hibicutaiwanin (4), hibicusin (5), and fifty-one known compounds: hibicuwanin A (6), 3) hibicuwanin B (7), 3) (7S,8S)-demethylcarolignan E (8), 3) threo-carolignan E (9), 4) erythro-carolignan E (10), 4) threo-1-C-syringylglycerol (11), 5) 9,9Ј-O-feruloyl-(Ϫ)-secoisolaricinresinol (12), 6) dihydrodehydrodiconiferyl alcohol (13), 7) boehmenan (14), 4) (Ϫ)-syringaresinol (15), 8) cleomiscosin A (16), 9) cleomiscosin C (17), 9) mansonone E (18), 10) mansonone H (19), 11) hibiscone C (20), 12) isohemigossypol-1-methyl ether (21), 13) gossyvertin (22), 14) N-trans-feruloyltyramine (23), 15) N-cis-feruloyltyramine (24), 16) 2-(2-hydroxytricosanoylamino)-1,3,4-hexadecanetriol (25), 17) myricerol (26), 18) myriceric acid A (27), 18) myriceric acid B (28), 18) myriceric acid C (29), 18) uncarinic acid A (30), 19) uncarinic acid B (31), 19) 3-oxo-olean-12-en-28-oic acid (32), 20) scopoletin (33), 21) scoparone (34), 22) 4-hydroxybenzoic acid (35), 15) ferulic acid (36), 15) methyl trans-ferulate (37), 23) methyl cis-ferulate (38), 24) lignocerylferulate (39), 25) caffeic acid (...…”

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confidence: 99%

Constituents from the Stems of Hibiscus taiwanensis

et al. 2005

Chem. Pharm. Bull.

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confidence: 99%

Constituents from the Stems of Hibiscus taiwanensis

et al. 2005

Chem. Pharm. Bull.

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“…24,25) LXRα is a target gene of the PPARγ, which has been recognized as a potential target for the treatment of T2DM because of its crucial role in regulating glucose metabolism. 26) Therefore, the activation of PPARγ/LXRα has been considered as a strategy for Fig.…”

Section: Resultsmentioning

confidence: 99%

Anti-diabetic properties ofDaphniphyllum macropodumfruit and its active compound

Koo

Kwak

Kang

2014

Bioscience, Biotechnology, and Biochemistry

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We evaluated in vitro anti-diabetic activities of 497 native plants of Jeju Island (South Korea) by measuring the induction of adipocyte differentiation. Among the plants, Daphniphyllum macropodum fruit extract (DME) had the highest peroxisome proliferatoractivated receptor γ (PPARγ) agonist activity and was therefore selected as a potential source of antidiabetic agents. To elucidate the active components of DME, constituent compounds were purified and their effects on the adipocyte differentiation were studied. Using activity-guided fractionation, four compounds were isolated from DME and their adipogenic effects were evaluated. Among the compounds isolated, 5,7-dihydroxychromone potently induced the differentiation of mouse 3T3-L1 preadipocytes. DME and 5,7-dihydroxychromone increased PPARγ and liver X receptor α (LXRα) mRNA expression levels. To determine whether the adipogenic effects we observed might affect serum glucose levels, we undertook in vivo experiment using streptozotocin-/high-fat diet-induced type 2 diabetes mouse model. DME supplementation reduced serum glucose, total cholesterol, and triacylglycerol levels in diabetes mice. These results suggest that DME may be useful for the prevention and treatment of type 2 diabetes mellitus. Moreover, it was proposed that 5,7-dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels.

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“…It is an unusual ester of N-benzoylphenylalanine and N-benzoylphenylalaninol and was first isolated from Aspergillus flavipes (Clark, Hufford & Robertson 1977). It is known majorly for its antitumor activity (Li et al 2012;Wu et al 2004;Yuan, Wang & Sun 2010), but there are currently no reports on the effect of asperphenamate on uterine contraction. Destigloylswietenine belongs to the limonoid class of plant secondary metabolites (Zhang et al 2009) with swietenine being first isolated from the seeds of Swetenia macrophylla in 1964 (Conolly et al 1964).…”

Section: Biological Effects Of Identified Compounds In D Filix-masmentioning

confidence: 99%

<i>Dryopteris filix-mas</i> (Dryopteridaceae) leaves inhibit mouse uterine activity

Bafor

Omokaro

Uwumarongie³

et al. 2017

JOMPED

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Background: The plant Dryopteris filix-mas has been used traditionally for its uterine-stimulant effects.Aim: The current study is therefore aimed at investigating and determining the effect of the leaves of D. filix-mas on uterine contractility in vitro.Setting: Fresh leaves of D. filix-mas were collected from a river bank in the south-western part of Nigeria.Methods: The leaves of D. filix-mas were cleaned, dried and extracted in methanol. The extract (0.07 µg/mL–21.0 µg/mL) was tested on the isolated mouse uteri in order to determine activity on spontaneous-induced uterine contractions. Subsequently the extract (0.005 mg/mL and 0.05 mg/mL) was tested on oxytocin-induced contraction (0.00017 ng/mL–4.98 ng/mL) in calcium-containing media, submaximal oxytocin-induced contraction (0.116 ng/mL) in calcium-free media and in the presence of high KCl-induced uterine contractions (80 mM). The extract was also subjected to mass spectrometric determination of secondary metabolites.Results: The plant extract inhibited spontaneous-induced contractions with IC50 amplitude = 658.41 ng/mL ± 0.11 ng/mL and IC50 frequency = 175.32 ng/mL ± 0.53 ng/mL. The plant extract inhibited oxytocin-induced and high KCl-induced uterine contractions (p < 0.01 at 0.5 mg/mL). The plant extract had no effect on oxytocin-induced contractions under calcium-free conditions. Secondary metabolites belonging to classes of fatty acids, alkaloids, saponin glycosides, amino acids, limonoids, terpenes and porphyrins were identified.Conclusion: The current study reports an inhibitory effect of the plant on uterine contractility in this study, suggesting possible application as a tocolytic or as a contraceptive, as most contraceptive plants have shown uterine-relaxing effect.

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Cytotoxic and Anti-HIV Principles from the Rhizomes of Begonia nantoensis

Cited by 79 publications

References 38 publications

Constituents from the Stems of Hibiscus taiwanensis

Constituents from the Stems of Hibiscus taiwanensis

Anti-diabetic properties ofDaphniphyllum macropodumfruit and its active compound

<i>Dryopteris filix-mas</i> (Dryopteridaceae) leaves inhibit mouse uterine activity

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