Cytotoxic Activity of Peronema canescens Jack Leaves on Human Cells: HT-29 and Primary Adenocarcinoma Colon Cancer

Ibrahim, Arsyik; Siswandono,; Ew, Bambang Prajogo

doi:10.5530/pj.2021.13.176

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…The results showed that the plant leaf extract showed potential cytotoxic activity in human HT-29 cancer cells with an IC50 value of 4.807μg/ml [17]. Follow-up research conducted by this research team, by using the same type of extract against HT-29 and primary adenocarcinoma colon cancer confirmed that sungkai plant really has anticancer potential through cell cycle inhibition, induces apoptosis and necrosis cells [18].…”

Section: Anticancermentioning

confidence: 74%

Therapeutic potentials of sungkai (Peronema canescens Jack.) an Indonesian luxurious woody plant

Kanedi¹,

Handayani²,

Setiawan³

2022

World J. Bio. Pharm. Health Sci.

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In Indonesia sungkai plant (Peronema canescens Jack.) categorized as a luxurious timber because the wood is used for various purposes such as: for houses construction, interior finishes, furniture and decorative veneer. Besides being used for its wood, the sungkai plant is also used as a medicinal plant to treat several diseases such as: fever, ringworm, and toothache.In this article, several pharmacological research results that verify the claims of traditional communities about the medicinal properties of this plant are presented. The results of the existing research indicate that the sungkai plant has therapeutic potential.

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Section: Anticancermentioning

confidence: 74%

Therapeutic potentials of sungkai (Peronema canescens Jack.) an Indonesian luxurious woody plant

Kanedi¹,

Handayani²,

Setiawan³

2022

World J. Bio. Pharm. Health Sci.

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“…The leaves and roots of sungkai have also long been used as traditional medicine in the Dayak Tunjung tribe as a medicine for fever, diuretic and rheumatic pain, and the Lembak Empat tribe in Bengkulu still uses the young leaves of sungkai to maintain health, treat high fever and malaria [1]. Currently, sungkai research focuses on leaves as an extract which has potential as an antipyretic [2] anti-inflammatory [3,4], antioxidant [5][6][7][8], antibacterial [9][10][11], Antihyperuricemia [12], anticancer [13,14], and antidiabetic [15,16].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Sungkai (Peronema cannescens Jack) leaves, Antioxidant Activity Test and Its Nanoemulsion Formulation

Nurfauziyah,

Yulizar,

Meliana

2024

E3S Web Conf.

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Sungkai (Peronema canescens J.) is an Indonesian native plant widely distributed on the islands of Kalimantan and Sumatra. Potential of these plants is related to the presence of secondary metabolites, which can be obtained through extraction. In its application, plant extract requires a delivery system that can penetrate well into the skin and maximise the efficacy of the active ingredients, such as nanoemulsion, which has high kinetic stability due to the smaller droplet size. The research was conducted to compare the yields from the two extraction methods, the presence of active compounds in the plants related to their properties as antioxidants and then formulated into nanoemulsion. The results showed that Sungkai leaves extract contains active metabolites such as alkaloids, flavonoids, tannins and saponins. The extraction of sungkai leaves yields 15.91% and 14.71% for CE and UAE methods. The total phenolic and flavonoid values were 27.74 and 41.88 mg GAE/g extract; 17.60 and 36.02 mg QE/g extract; and IC50 values of 50.78 and 53.50, included in the strong antioxidant category. Stable nanoemulsion formulation was obtained by adding 1 gram of olive oil with a homogenisation speed of 15000 rpm, with particle size of 83.4 nm and a polydispersity index of 0.455.

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“…People use sungkai leaves as cold medicine, for fever ringworms, and as a mouthwash to prevent toothache. Based on previous research, sungkai leaves have bioactivity properties: antioxidant, antibacterial [4] antidiabetic [2], antipyretic [5], imunostimulator [6], cytotoxic [7], Antiplasmodium [8].…”

Section: Introductionmentioning

confidence: 99%

GC-MS Screening of Sungkai Leaves and Relation With Its Antioxidant Capacity

Santoni

Jaswandi

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Sungkai (Peronema canescens Jack) is a wild plant that grows in Kalimantan and Sumatera, Indonesia, and is used as traditional medicine. This study aimed to determine the components of chemical compounds in young leaves, half-old leaves, and old leaves of sungkai and their antioxidant activity. Gas Chromatography-Mass Spectrometry analyzed chemical compounds (GC-MS), and antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazil (DPPH). The analysis of chemical compounds showed that the chemical compounds were almost similar in young, half-old, and old leaves of sungkai with different intensities. Antioxidant activity showed the strong activity with IC50 of young leaves of sungkai is 26.389 mg/L, half-old leaves 29.874 mg/L and old leaves 30.9183 mg/L.

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Cytotoxic Activity of Peronema canescens Jack Leaves on Human Cells: HT-29 and Primary Adenocarcinoma Colon Cancer

Cited by 4 publications

References 21 publications

Therapeutic potentials of sungkai (Peronema canescens Jack.) an Indonesian luxurious woody plant

Therapeutic potentials of sungkai (Peronema canescens Jack.) an Indonesian luxurious woody plant

Extraction of Sungkai (Peronema cannescens Jack) leaves, Antioxidant Activity Test and Its Nanoemulsion Formulation

GC-MS Screening of Sungkai Leaves and Relation With Its Antioxidant Capacity

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