Cytotoxic Activity of Crude Extracts from<i>Astragalus Chrysochlorus</i>(Leguminosae)

Karagöz, Ali; Turgut-Kara, Neslihan; Demirgan, Recep

doi:10.1080/13102818.2007.10817449

Cited by 22 publications

(15 citation statements)

References 20 publications

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“…However, POX activity was still higher than in control callus cultures. In our previous studies, crude ethanol and ethyl acetate extracts of this plant exhibited cytotoxic activity and apoptosis-inducing properties (Karagoz et al 2007) and also antioxidant effects (Hasancebi, unpublished data). Besides the biotechnological importance of Astragalus species, in callus tissues of the secondary Se accumulator A. chrysochlorus it was found that antioxidant enzymes and SMT gene expression were affected by Se treatment in callus tissues.…”

Section: Discussionmentioning

confidence: 99%

Selenium induced selenocysteine methyltransferase gene expression and antioxidant enzyme activities in Astragalus chrysochlorus

Çakır¹,

Turgut-Kara²,

Arı³

2016

Acta Botanica Croatica

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-Astragalus sp. are used in folk medicine because of their biological activities and are known for the ability to accumulate high levels of selenium (Se). The purpose of this study was to explore gene expression of selenocysteine methyltransferase (SMT), responsible for forming MeSeCys, and activities of ascorbate peroxidase (APX), peroxidase (POX), catalase (CAT) and glutathione reductase (GR) enzymes in callus tissues of Astragalus chrysochlorus growing in different Se-containing media. Quantitative real-time polymerase chain reaction assay was done for quantifi cation of SMT gene transcript and it was normalized to actin gene. It was found that transcript level of callus tissues grown at 5.2 μM and 26.4 μM Se-enriched media was lower than that of the control callus. In contrast, a high level of Se (132.3 μM) in the medium caused an approximately 4.26 times higher level of SMT transcript in callus than the control. APX, POX, CAT and GR enzymes were all effected by different Se concentrations. While POX and APX activities were higher then control, CAT and GR activities decreased. These results show that an increase of SMT gene expression led to a rise in APX and POX, but a suppression of CAT and GR enzymes activities in Astragalus chrysochlorus. This suggests that Se could be involved in the antioxidant metabolism in Astragalus chrysochlorus.

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Section: Discussionmentioning

confidence: 99%

Selenium induced selenocysteine methyltransferase gene expression and antioxidant enzyme activities in Astragalus chrysochlorus

Çakır¹,

Turgut-Kara²,

Arı³

2016

Acta Botanica Croatica

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“…Based on IC 50 value, cocoa leaf extract was the most potent anticancer activity against MCF-7 with IC 50 value about 41.43 ± 3.26 µg/ml was significantly different (P<0.05) compared to cocoa shell (fermented) and pith extracts against A549 and MDA-MDB-123 respectively but, there were no significant difference (P>0.05) of antiproliferative activity between cocoa leaf extract against MCF-7 with cocoa cherelle, shell (fermented) and shell unfermented against HeLa, HepG2 and HT29 respectively Table 1. This could be due to the synergistic effects of the various components present in the extracts and previous report also showed that crude plant extracts are more active pharmacologically than their isolated active principles [23]. Furthermore, extract from Theobroma cacao especially cocoa bean also reported to possessed anticancer agents against various cancer cell lines due to the polyphenolic contents such as procyanidin present in the cocoa [24].…”

Section: Screening Cocoa Plant Parts For Antiproliferative Activitymentioning

confidence: 99%

Anticancer Agents from Non-Edible Parts of Theobroma cacao

Zainal¹

2014

Nat Prod Chem Res 2014

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“…(Ericaceae) Antifibrotic [49,50] 11 Diadzein Pueraria lobata (Fabaceae) Antithrombotic, antiallergic [51] 12 Diosmin Hyssopus officinali (Lamiaceae) Antiinflammatory [52] 13 Galangin Helichrysum aureonitens (Asteroideae) Antibacterial Antiviral [53,54] www.wjpps.com Anti inflammatory, Depression [68,69,70] 22 Hyperoside Tilia cordata (Tiliaceae)…”

Section: Chemistry Of Flavonoidsmentioning

confidence: 99%

“…Cannabis sativa (Cannabaceae) Mimosa pudica (Mimosoideae) Anti oxidant [85] 34 Oroxylin Oroxylum indicum (Bignoniaceaea) Apoptosis [86] www.wjpps.com [87] 36 Pongamol Tephrosia purpurea (Fabaceae) antihyperglycemic [88] 37 Prunetine Butea monosperma (Fabaceae) Anti oxidant [89] 38 Purpurin Tephrosia purpurea (Fabaceae) Antifungal [90] 39 Pinocembrin Nicrembergia hippomania (Solanaceae) Anti-feedant [91] 40 Peonidin Vitis vinifera (Vitaceae) Antioxidant [92] www.wjpps.com Antioxidant, Anticancer [93] 42 Petunidin Solanum tuberosum (Solanaceae) Antioxidant [94] [97] 45 Tambuletin Zanthoxylum alatum (Rutaceae) Antioxidant [98] www.wjpps.com Anti-inflammatory, Antioxidant [69] 49 Vitexin Passiflora incarnate (Passifloraceae) Antioxidant , Antithyroid [100] 50 Vitexicarpin Vitex rotundifolia (Lamiaceae) Antiproliferative [82] www.wjpps.com Vol 6, Issue 5, 2017. 500…”

Section: Chemistry Of Flavonoidsmentioning

confidence: 99%