Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro

Kumar, V. Prashanth; S, Shashidhara; Kumar, Mukesh; Sridhara, B.Y.

doi:10.1016/s0367-326x(01)00266-0

Cited by 63 publications

(33 citation statements)

References 4 publications

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“…It has been used as a traditional folk medicine because of its diuretic and antipyretic effects. In traditional Chinese medicine, it has been used for centuries to cure inflammation, edema, mastitis and hepatic cancer (Sultana et al, 1995;Prashanth et al, 2001). Previous studies reported that ethanol extract of SNL suppress the oxidant-mediated degradation of calf thymus DNA (Sultana et al, 1995) and SNL exhibited anti-neoplastic effect on several human tumor cell lines (Hu et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of fraction 1a of polysaccharides isolated from Solanum nigrum Linne on thymus in tumor-bearing mice

Peng

et al. 2010

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Protective effects of fraction 1a of polysaccharides isolated from Solanum nigrum Linne on thymus in tumor-bearing mice

Peng

et al. 2010

Journal of Ethnopharmacology

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“…It has been used in traditional folk medicine because of its diuretic and antipyretic effects. In the traditional Chinese medicine, it has been used for centuries to cure inflammation, edema, mastitis and hepatic cancer (Sultana et al, 1995;Prashanth et al, 2001). Previous studies reported that a SNL ethanol extract suppressed the oxidantmediated degradation of calf thymus DNA (Sultana et al, 1995) and SNL exhibited an antineoplastic effect on several human tumor cell lines (Hu et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Antitumor activity of crude polysaccharides isolated from Solanum nigrum Linne on U14 cervical carcinoma bearing mice

Tao

et al. 2007

Phytotherapy Research

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Solanum nigrum Linne (SNL) has been used in traditional Chinese medicine for centuries because of its diuretic and antipyretic effects. The present study examined the effect of the crude polysaccharides isolated from Solanum nigrum Linne (SNL-P) on tumor growth. SNL-P had a significant growth inhibition effect on cervical cancer (U14) of tumor-bearing mice. Further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly, the expression of Bax increased and the expression of Bcl-2 and mutant p53 decreased dramatically in cervical cancer sections after oral administration of SNL-P for 12 days. Moreover, SNL-P treatment decreased the level of blood serum TNF-alpha. These results indicated that the tumor growth inhibition of SNL-P administration might correlate with the reduction of TNF-alpha level of blood serum, which resulted in a massive necrosis in tumor tissues and the up-regulation of Bax and down-regulation of Bcl-2 and mutant p53 gene expression, which triggered apoptosis in tumor cells. These findings demonstrated that the SNL-P is a potential antitumor agent.

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“…It offers gastroprotection against aspirin induced ulcer by significantly blocking lipid peroxidation. Prashanth kumar et al have reported that S.nigrum also exhibited 1. significant hydroxyl radical scavenging potential, thus suggesting its propable mechanism of cytoprotection (23). Scavenging activity of this extract also reduces lipid peroxidation.…”

Section: Discussionmentioning

confidence: 81%

Antioxidant effect of methanolic extract ofSolanum nigrum berries on aspirin induced gastric mucosal injury

Jainu

Devi

2004

Indian J Clin Biochem

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The antiulcerogenic effects of the methanolic extract of Solanum nigrum berries (SBE) on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa have been investigated. Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides, which were elevated highly in rats with acute gastric mucosal injury was taken as an index of oxidative stress .The activities of antioxidant defense enzymes were also decreased considerably by oral gastric adminisb'alJon of aspirin. The decreased levels of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with (SBE) when compared to the ulcer induced rats. The results indicate that (SBE) may exert its gastroprotective effect by a free radical scavenging action. Our observations suggest that (SBE) may have considerable therapeutic potential in the treabnent of gastric diseases.

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Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro

Cited by 63 publications

References 4 publications

Protective effects of fraction 1a of polysaccharides isolated from Solanum nigrum Linne on thymus in tumor-bearing mice

Protective effects of fraction 1a of polysaccharides isolated from Solanum nigrum Linne on thymus in tumor-bearing mice

Antitumor activity of crude polysaccharides isolated from Solanum nigrum Linne on U14 cervical carcinoma bearing mice

Antioxidant effect of methanolic extract ofSolanum nigrum berries on aspirin induced gastric mucosal injury

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