Antioxidant effect of methanolic extract ofSolanum nigrum berries on aspirin induced gastric mucosal injury

Abstract

The antiulcerogenic effects of the methanolic extract of Solanum nigrum berries (SBE) on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa have been investigated. Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides, which were elevated highly in rats with acute gastric mucosal injury was taken as an index of oxidative stress .The activities of antioxidant defense enzymes were also decreased considerably by oral gastric adminisb'alJon of aspirin. The decreased levels of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with (SBE) when compared to the ulcer induced rats. The results indicate that (SBE) may exert its gastroprotective effect by a free radical scavenging action. Our observations suggest that (SBE) may have considerable therapeutic potential in the treabnent of gastric diseases.

Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: Possible mechanism for the inhibition of acid formation

“…Previous reports indicated that Solanum nigrum fruits possess beneficial activity as antiulcer, antioxidant and antitumor promoting agent in rats (Prashanth Kumar et al, 2001;Son et al, 2003;Jainu and Devi, 2004). Solanum nigrum fruits are very commonly used as hepatoprotective agents (Raju et al, 2003), which also afford protection against free radical mediated damage (Bardhan et al, 1985).…”

Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

“…Some studies have revealed that reactive oxygen species (ROS) and lipid peroxidation are implicated in the pathogenesis of ethanol induced gastric lesions and gastrointestinal damage and that they attack and damage many biological molecules such as prostaglandins. After an initial reaction with ROS, a continuing chain reaction causes cell injury and ultimately cell death [27][28][29][30][31] . Therefore, treatment with antioxidants and free radical scavengers can decrease ethanol induced gastric mucosal damage.…”

Anti-Ulcer Activity ofAdhatoda vasicaNees

“…One of the major factors is its rapid penetration into the gastric mucosa which leads to an increased mucosal permeability and the release of vasoactive factors which cause vascular damage and gastric injury. 16,17 Gastric injury in Model B is associated with enhanced production and accumulation of gastric acid and in turn pepsin leading to auto digestion of the gastric mucosa and breakdown of mucosal barrier. Accumulation of activated neutrophils in the gastric mucosa may be a source of this free radical generation.…”