Cytometric features of cell nuclei of adenocarcinoma in situ and invasive adenocarcinoma of the cervix

Use of Nuclear Morphometry Characteristics to Distinguish between Normal and Abnormal Cervical Glandular Histologies

“…The data used in this article is the same as that described in [25] and [27]. A retrospective computerized search through the pathology records at the M.D.…”

“…Previously, West et al found several QP features where the means significantly differed across cell types [27]. The cellular measurements were taken using the Cyto-Savant TM , one of the commercially available image analysis systems.…”

Optical Technologies and Molecular Imaging for Cervical Neoplasia: A Program Project Update

“…Individuals associated with this core have done extensive work to address each of the technology development categories outlined above, including statistical analyses and algorithm development for several research components (23, 25–27, 30, 36, 38–40, 50, 52–53, 55–59, 62, 65, 67, 69, 71, 74–75, 81, 85–87, 92–93, 95–96, 98–99, 103, 105, 113–118). They have also worked closely with the other research cores associated with this project (30, 64, 72, 106–108, 110–111, 118–121). This group has also been responsible for the creation and proper maintenance of our secure patient database – and the development of software and statistical approaches for analyzing this collected information (102, 122).…”

“…All of the cytologic and histopathologic specimens needed for clinical and quantitative assessment have been collected and managed by this core. This core has also developed imaging systems for evaluating morphometric and architectural features on tissue cross-sections, with phenotypic scores calculated by this method correlating well with pathology classifications and HPV status (48, 66–68, 70, 73, 120–121). Algorithms based on this approach have had particular utility in characterizing the underlying biology of cervical disease.…”