Optical Technologies and Molecular Imaging for Cervical Neoplasia: A Program Project Update

Buys, Timon P.H.; Cantor, Scott B.; Guillaud, Martial; Adler‐Storthz, Karen; Cox, Dennis D.; Okolo, Clement Abu; Arulogon, Oyedunni; Oladepo, Oladimeji; Basen-Engquist, Karen; Shinn, Eileen H.; Yamal, José‐Miguel; Scheurer, Michael E.; Niekerk, Dirk van; Malpica, Anaís; Matisic, Jasenka; Staerkel, Gregg; Atkinson, E. Neely; Bidaut, Luc; Lane, Pierre; Benedet, J.L.; Miller, Dianne; Ehlen, Tom; Price, Roderick; Adewole, Isaac F.; MacAulay, Calum; Follen, Michele

doi:10.1016/j.genm.2011.08.002

Cited by 12 publications

(8 citation statements)

References 119 publications

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“…Participants in this study were those taking part in a larger National Institutes of Health-sponsored clinical trial to evaluate emerging optical technologies for diagnosis of cervical dysplasia [ 22 , 23 ]. The protocol of the parent study (Development and Application of a Multispectral Digital Colposcope and Probe Algorithm for Detection of Cervical Intraepithelial Neoplasia) was reviewed and approved by the TTUHSC Institutional Review Board (IRB) for the Protection of Human Subjects (IRB # E12117).…”

Section: Methodsmentioning

confidence: 99%

Predictors of timely diagnostic follow-up after an abnormal Pap test among Hispanic women seeking care in El Paso, Texas

et al. 2021

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Background Diagnostic follow-up of women with an abnormal Pap test is necessary to resolve the risk developing cervical cancer. The purpose of this study is to describe patient characteristics associated with timely receipt of a diagnostic colposcopy after an abnormal Pap test among Hispanic women in El Paso, a Texas-Mexico border city. Methods We conducted a retrospective chart review of Hispanic patients seen at an academic colposcopy clinic following an abnormal Pap test. An optimal diagnostic interval to colposcopy was based on a National Breast and Cervical Cancer Early Detection Program (NBCCEDP) quality indicator and was defined as receipt of colposcopy within 90 days or less from the date of an abnormal Pap test. Risk ratios (RR) were calculated by building a generalized linear model fit using a Poisson distribution, log link, and robust variance. Results Overall, 177 of the 270 women (65.6%) received follow-up within an optimal diagnostic interval. After adjusting for other variables in the model, women who were 30 years of age or older were 32% more likely to have an optimal interval than younger women (adjusted RR = 1.32, P < 0.01). High school graduates were less likely than more educated women to have an optimal interval (adjusted RR = 0.68, P < 0.01). Participation in the NBCCEDP was not associated with receipt of follow-up within an optimal diagnostic interval. Conclusions Compared with women with greater educational attainment, high school graduates were less likely to receive follow-up within an optimal diagnostic interval, as were younger (< 30 years) women compared with older women. Participation in the NBCCEDP was not associated with receipt of care within an optimal diagnostic interval.

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Section: Methodsmentioning

confidence: 99%

Predictors of timely diagnostic follow-up after an abnormal Pap test among Hispanic women seeking care in El Paso, Texas

et al. 2021

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“…This study serves as a critical step towards utilizing confocal approaches in an in vivo clinical application. This study was part of an ongoing project with the ultimate goal of integrating advances in cancer biology and optical technology to develop cost-effective tools to aid in early detection of cervical cancer [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, more work needs to be done to assess the true value of this technology in clinical settings. In the lats 10 years, our group has been facing numerous challenges, mostly related to instrumentation, implementation, quality control, and biological variability to implement reflectance and fluorescence spectroscopy in clinic [ 24 ]. We had underestimated the difficulty and complexity of moving optical technology from bench to clinic.…”

Section: Introductionmentioning

confidence: 99%

Quantification of confocal fluorescence microscopy for the detection of cervical intraepithelial neoplasia

et al. 2015

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BackgroundCervical cancer remains a major health problem, especially in developing countries. Colposcopic examination is used to detect high-grade lesions in patients with a history of abnormal pap smears. New technologies are needed to improve the sensitivity and specificity of this technique. We propose to test the potential of fluorescence confocal microscopy to identify high-grade lesions.MethodsWe examined the quantification of ex vivo confocal fluorescence microscopy to differentiate among normal cervical tissue, low-grade Cervical Intraepithelial Neoplasia (CIN), and high-grade CIN. We sought to (1) quantify nuclear morphology and tissue architecture features by analyzing images of cervical biopsies; and (2) determine the accuracy of high-grade CIN detection via confocal microscopy relative to the accuracy of detection by colposcopic impression. Forty-six biopsies obtained from colposcopically normal and abnormal cervical sites were evaluated. Confocal images were acquired at different depths from the epithelial surface and histological images were analyzed using in-house software.ResultsThe features calculated from the confocal images compared well with those features obtained from the histological images and histopathological reviews of the specimens (obtained by a gynecologic pathologist). The correlations between two of these features (the nuclear-cytoplasmic ratio and the average of three nearest Delaunay-neighbors distance) and the grade of dysplasia were higher than that of colposcopic impression. The sensitivity of detecting high-grade dysplasia by analysing images collected at the surface of the epithelium, and at 15 and 30 μm below the epithelial surface were respectively 100, 100, and 92 %.ConclusionsQuantitative analysis of confocal fluorescence images showed its capacity for discriminating high-grade CIN lesions vs. low-grade CIN lesions and normal tissues, at different depth of imaging. This approach could be used to help clinicians identify high-grade CIN in clinical settings.

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“…The cases in this analysis represent a subset of participants from a clinical trial to evaluate emerging technologies for the identification of cervical neoplasia [8]. Trial participants included women with abnormal Papanicolaou test screening presenting for colposcopy at one of three participating hospitals in the U.S. (Houston, Texas) and Canada (Vancouver, British Columbia) between 1999 and 2005, as well as community volunteers with no prior history of dysplasia.…”

Section: Methodsmentioning

confidence: 99%

Nativity Differences in Behaviors Associated with High-Risk HPV Infection Among Hispanic Women in Houston, Texas, USA

Montealegre

Follen²,

Scheurer

2013

J Immigrant Minority Health

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While Hispanics in the U.S. are a population with significant within-group heterogeneity, epidemiologic studies often aggregate Hispanics into one homogenous group without considering differences by nativity. The objective of this study is to evaluate nativity differences in the risk behavior profile associated with prevalent high risk human papillomavirus (HR-HPV) among U.S.- and foreign-born Hispanic women. Using a clinical trial dataset, we compare risk behavior and HR-HPV infection patterns among U.S.- and foreign-born participants and assess factors associated with infection in each group. While the prevalence of HR-HPV infection was similar among U.S.- and foreign-born participants, U.S.-born cases had a higher HR-HPV risk profile. The similar prevalence of HR-HPV despite foreign-born women's lower risk profile suggests a role for unmeasured risk factors among foreign-born Hispanics. More importantly, nativity differences in behavioral risk factors associated with HR-HPV suggest the need to further research cervical cancer risk factors among disaggregated Hispanic subgroups.

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Optical Technologies and Molecular Imaging for Cervical Neoplasia: A Program Project Update

Cited by 12 publications

References 119 publications

Predictors of timely diagnostic follow-up after an abnormal Pap test among Hispanic women seeking care in El Paso, Texas

Predictors of timely diagnostic follow-up after an abnormal Pap test among Hispanic women seeking care in El Paso, Texas

Quantification of confocal fluorescence microscopy for the detection of cervical intraepithelial neoplasia

Nativity Differences in Behaviors Associated with High-Risk HPV Infection Among Hispanic Women in Houston, Texas, USA

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