Cytology of Ascitic Fluid in a Patient with Metastasizing Malignant Brenner Tumor of the Ovary

Ascitic Fluid Cytology in Malignant Brenner Tumor

“…1,3 Despite the fact that 10% of MBTs are associated with ascites, few reports on the cytology of ascitic fluid in MBT have been published. 2,4,5 The presence of an ovarian mass associated with squamous cells in peritoneal fluid regardless of the status of nuclear abnormalities is, for all practical purposes, diagnostic of metastatic squamous cell carcinoma.…”

“…3 The occurrence of a papillary transitional component with some nuclear grooves and atypical squamous cells should raise the possibility of at least a proliferating Brenner tumor. 2,4,5 Rarely, a slow leak from a dermoid cyst into the peritoneal cavity may lead to granulomatous peritonitis that can mimic metastatic carcinoma. Presence of benign squamous cells, anucleated squames, keratinous material and cholesterol against an inflammatory background supports dermoid cyst diagnosis and eliminates MBT.…”

“…1 Peritoneal effusion has been found in only 10% of patients. 2 We report a case of MBT with ascites and describe the cytologic findings of the serous effusion in this tumor.…”

Abdominopelvic washings in gynecologic pathology: A comprehensive review

“…121 Nucleoli are conspicuous and there is a moderate amount of cytoplasm. 122,123 Extensive squamous differentiation can be seen, necessitating immunohistochemical studies to identify the origin of the tumor. 121 Eosinophilic extracellular material may be present.…”

“…Nuclear grooves may not be prominent and occasional microcystic space formation may be seen. 122,123 Extensive squamous differentiation can be seen, necessitating immunohistochemical studies to identify the origin of the tumor. 120 An immunoprofile consistent with Brenner tumor would include positivity for CK7, p63, Gata-3, uroplakin, and thrombomodulin; and negativity for WT-1.…”