Ascitic Fluid Cytology in Malignant Brenner Tumor

Driss, Maha; Mrad, Karima; Dhouib, R.; Doghri, Raoudha; Abbès, Imen; Romdhane, Khaled Ben

doi:10.1159/000325184

Cited by 15 publications

(25 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In smears they appear hypercellular, with reactive mesothelial cells, lymphocytes and squamous neoplastic cells. [79] However, neoplastic squamous cells are more commonly associated with endometrioid adenocarcinoma with extensive squamous differentiation and less frequently with malignant transformation of mature teratomas. [80]…”

Section: Introductionmentioning

confidence: 99%

Abdominopelvic washings: A comprehensive review

Rodrı́guez¹,

Khalbuss²,

Austin³

et al. 2013

CytoJournal

View full text Add to dashboard Cite

Intraperitoneal spread may occur with gynecological epithelial neoplasms, as well as with non-gynecological malignancies, which may result in serosal involvement with or without concomitant effusion. Therefore, washings in patients with abdominopelvic tumors represent important specimens for cytologic examination. They are primarily utilized for staging ovarian cancers, although their role has decreased in staging of endometrial and cervical carcinoma. Abdominopelvic washings can be positive in a variety of pathologic conditions, including benign conditions, borderline neoplastic tumors, locally invasive tumors, or distant metastases. In a subset of cases, washings can be diagnostically challenging due to the presence of co-existing benign cells (e.g., mesothelial hyperplasia, endosalpingiosis, or endometriosis), lesions in which there is only minimal atypia (e.g., serous borderline tumors) or scant atypical cells, and the rarity of specific tumor types (e.g., mesothelioma). Ancillary studies including immunocytochemistry and fluorescence in situ hybridization may be required in difficult cases to resolve the diagnosis. This article provides a comprehensive and contemporary review of abdominopelvic washings in the evaluation of gynecologic and non-gynecologic tumors, including primary peritoneal and mesothelial entities.

show abstract

Section: Introductionmentioning

confidence: 99%

Abdominopelvic washings: A comprehensive review

Rodrı́guez¹,

Khalbuss²,

Austin³

et al. 2013

CytoJournal

View full text Add to dashboard Cite

show abstract

“…In our case the patient presented with watery discharge, polymenorrhoea and menorrhagia. Peritoneal effusion is rare in MBTs found in only 10% of patients [9] . In this case there was 100 ml of ascitic fluid which was negative for malignant cells.…”

Section: Discussionmentioning

confidence: 97%

Malignant Brenner Tumour – A Rare Entity

M¹

2017

JMSCR

View full text Add to dashboard Cite

show abstract

“…35,121 Perinuclear vacuoles and individual plasmacytoid cells with abundant dense blue cytoplasm may be observed. 120 An immunoprofile consistent with Brenner tumor would include positivity for CK7, p63, Gata-3, uroplakin, and thrombomodulin; and negativity for WT-1. 121 Malignant Brenner tumors may show cytomorphologic features similar to those seen in urine specimens with high-grade urothelial carcinoma, including extreme nuclear atypia, prominent nucleoli, coarse chromatin, and markedly elevated nuclear to cytoplasmic ratio.…”

Section: Ovarian Brenner Tumorsmentioning

confidence: 99%

“…68 Effusions are present in 10% of patients with malignant Brenner tumors. 120 Cytologic features of benign Brenner tumors in APW, in cases of rupture, include clusters and sheets of bland transitional cells with oval to elongated nuclei with grooves, or coffee-bean-like nuclei. 121 Nucleoli are conspicuous and there is a moderate amount of cytoplasm.…”

Section: Ovarian Brenner Tumorsmentioning

confidence: 99%

“…122,123 Extensive squamous differentiation can be seen, necessitating immunohistochemical studies to identify the origin of the tumor. 120 An immunoprofile consistent with Brenner tumor would include positivity for CK7, p63, Gata-3, uroplakin, and thrombomodulin; and negativity for WT-1. Evidently, the presence of malignant appearing tumor cells in APW with the aforementioned cytomorphologic and immunohistochemical features is often seen in high-grade urothelial carcinoma.…”

Section: Ovarian Brenner Tumorsmentioning

confidence: 99%

See 1 more Smart Citation

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Schulte

Lastra

2016

Diagnostic Cytopathology

View full text Add to dashboard Cite

Abdominopelvic washings (APW) performed during gynecologic surgeries have become a common specimen evaluated by cytopathologists. Their role in staging of female genital tract tumors has changed significantly since they were first described, and continue to evolve. The ability of these washings to detect microscopic disease, even in the absence of gross disease, warrants the critical role that these washings play in the staging of certain female gynecologic tract tumors, allowing for optimal staging and subsequent treatment of the patient. Irrespective of the underlying pathology, the gamut of cytomorphologic findings that may be observed in APW is extensive, and ranges from benign lesions that may act as mimickers of malignancy, to both common and rare malignancies. This review discusses the changing role of APW in the staging of gynecologic tumors, and highlights the salient cytomorphologic features of these lesions, with emphasis in their correct identification, including cautionary notes to avoid over or misinterpretation. Diagn. Cytopathol. 2016;44:1039-1057. © 2016 Wiley Periodicals, Inc.

show abstract

Ascitic Fluid Cytology in Malignant Brenner Tumor

Cited by 15 publications

References 5 publications

Abdominopelvic washings: A comprehensive review

Abdominopelvic washings: A comprehensive review

Malignant Brenner Tumour – A Rare Entity

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Contact Info

Product

Resources

About