Introduction: Breast cancer is the leading cause of cancer deaths among women worldwide. Breast cancer clinically presents as breast lump.Fine needle aspiration cytology (FNAC) and breast ultrasound (sonomammography) is pivotal in characterization of a breast lump as benign and malignant lesion. There is a need to study radiological and cytological correlation of breast lesions with histopathological findings to evaluate the diagnostic accuracy of sonomammography and FNAC. Material and Methods: A prospective, quantitative and descriptive study was conducted in the department of Radiology, Father Muller Medical College Hospital, Mangalore. Patients who were evaluated for suspicious breast lump with a breast ultrasound, FNAC and biopsy from January 2017 to December 2018 were included in the study. Results: In this study, diagnostic accuracy for breast FNAC (98.7%) was found to be better than that of sonomammography (92.5%). Fine needle aspiration cytology of breast lump plays an important role when it is difficult to determine the nature of breast lump by clinical and radiological examination. In this study breast FNAC was found to have sensitivity of 98.4% and specificity of 95.7%. Sonomammography had a sensitivity of 90.6%and specificity of 97.8. Conclusion: Present study confirms the higher combined sensitivity, specificity and accuracy for ultrasonography and fine needle aspiration cytology in categorisation of breast lump as benign and malignant. USG is better indetection of benign lesions whereas cytology is better in case of malignancies. The triple assessment is an accurate, simple and cost-effective method for the evaluation of breast cancer and can be applied at our centre as a safe alternative for open biopsy when it is concordant and open biopsy must be reserved only for discordant results. This will subsequently reduce the number ofbreast biopsies significantly.