Cytokine Profile in Visceral Obesity and Adverse Cardiovascular Prognosis of Myocardial Infarction

Gruzdeva, Valentina; Акбашева, Е.; Матвеева, Г.; Дылева, А.; Паличева, И.; Каретникова, Н.; Borodkina, A G; Коков, Array Н.; Федорова, С. И.; Барбараш, Л. С.

doi:10.15789/1563-0625-2015-3-211-220

Cited by 3 publications

(1 citation statement)

References 22 publications

(30 reference statements)

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“…В основе этих видов анализа лежит связывание с моноклональными антителами, фиксированными на поверхности микрочастиц или микрошариков. Проведенный нами анализ отечественной научной литературы иммунологического профиля на примере двух российских журналов «Медицинская иммунология» и «Инфекция и иммунитет» показал, что наибольшее распространение при проведении клинико-иммунологических исследований с определением содержания цитокинов в сыворотке/плазме крови получил твердофазный ИФА [4,6,7,13,14,15,16,17,23,25,26,27,28,29,31, 32] и мультиплексный иммуноанализ в формате хМАР- [2,9,19,20,21,22,30] и СВА-технологий [3,18].…”

Section: цитокины в периферической крови здоровыхunclassified

Methodological Issues of Determining Concentrations of Some Cytokines in Peripheral Mblood From Healthy Individuals

Arsentieva

Тотолян

2018

Med. immunol.

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Cytokines are the most important factors in pathogenesis of infectious, allergic, autoimmune, lymphoproliferative diseases and immunopathological processes. Many cytokines are very useful therapeutic targets for immunodiagnostics of different human diseases. Measurement of the cytokine levels by immunochemical methods in various biological fluids is usually used for diagnostic evaluation. Content analysis of research articles from two Russian immunological journals, “Meditsinskaya Immunologiya” = “Medical Immunology (Russia)” and “Infektsiya i immunitet” = “Russian Journal of Infection and Immunity,”, shows that ELISA, xMAP multiplex immunoassay, and CBA technologies are the most common methods used in clinical and immunological studies aimed for determination of cytokine contents in blood serum/plasma. Normal ranges of some plasma/serum cytokines in healthy individuals were subject to wide variations when using different methods and specific reagents from various manufacturers. The normal ranges applied by the CBA-technology, are significantly higher than appropriate values obtained by ELISA or xMAP-technologies. Most studies included a small control group, usually limited by 15-20 persons. In most of these works, blood serum samples were used for assays, whereas EDTA-conserved plasma was taken only in few studies. It has been concluded that the results of cytokine measurements in blood serum/plasma in healthy individuals vary in wide ranges, and depend on many factors, e.g., initial sampling material, mode of technology, type of test systems, and characteristics of the group under study: number of patients, age, gender, geographical factor, etc. The mentioned data demonstrate a need for large-scale multicenter clinical studies, in order to standardize measurements of the cytokine levels in human peripheral blood and to specify their normal values.

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Section: цитокины в периферической крови здоровыхunclassified

Methodological Issues of Determining Concentrations of Some Cytokines in Peripheral Mblood From Healthy Individuals

Arsentieva

Тотолян

2018

Med. immunol.

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Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease

et al. 2017

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The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.

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Cytokines and atherosclerosis – new research directions

et al. 2018

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This review generalizes the current evidence on the content of the pro- and anti-inflammatory cytokines in patients’ blood serum with atherosclerotic lesions of the coronary, carotid and iliac arteries. The results gave the ability to assess cytokine immune cells of atherosclerotic plaques. Also the results of national and international research allowed the assessment of the prognostic value of cytokine content.

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Cytokine Profile in Visceral Obesity and Adverse Cardiovascular Prognosis of Myocardial Infarction

Cited by 3 publications

References 22 publications

Methodological Issues of Determining Concentrations of Some Cytokines in Peripheral Mblood From Healthy Individuals

Methodological Issues of Determining Concentrations of Some Cytokines in Peripheral Mblood From Healthy Individuals

Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease

Cytokines and atherosclerosis – new research directions

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