Cytokine Milieu in Psoriasis and Cardiovascular Disease May Explain the Epidemiological Findings Relating These 2 Diseases

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

“…Much like rheumatoid arthritis 104 and systemic lupus erythematosus 105 , patients with psoriasis and psoriatic arthritis have increased levels of interleukins and proinflammatory cytokines that may be a pathophysiologic link to atherosclerosis and vascular disease. 106 While this inflammatory milieu is a plausible basis for these associations, it remains possible that other, yet undiscovered, explanations may exist. At a minimum, these observations suggest that clinicians should be vigilant about identifying and treating CVD risk factors in this population.…”

Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus: A Case–Control Study

“…Over the last decade, cardiovascular risk factors have been evaluated in psoriasis, and psoriasis has been shown in association with metabolic diseases including metabolic syndrome (MS), obesity, dyslipidemia and diabetes [2][3][4]. It has been proposed that a chronic inflammatory state may cause increased risk for cardiovascular diseases such as atherosclerosis, myocardial infarction (MI) and stroke in patients with psoriasis [5,6]. It has also been shown that LP is associated with dyslipidemia, and the inflammatory process may lead to lipid metabolism disorders such as an increase in serum triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL) levels [7,8].…”

Genetic factors in contact allergy-review and future goals

“…One may speculate about a more general trait associated with inflammatory diseases (192), instead of, or in addition to, disease‐specific polymorphisms. The attempts to group autoimmune diseases according to shared pathogenesis and shared genetics (183, 193) may go beyond the narrow area of ‘immunological diseases' to inflammation‐related diseases in a more general sense, as the association between asthma and inflammatory bowel disease (192) or between psoriasis and cardiovascular diseases might suggest (194, 195). Such findings have prompted some to suggest that the textbooks of medicine need to rewritten to account for the interconnectivity of the molecular bases underlying distinct diseases (140).…”