Cytokine levels in amniotic fluid and inflammatory changes in the placenta from normal deliveries at term

Halgunset, Jostein; Johnsen, Harald; Kjøllesdal, Anne Molne; Qvigstad, Elisabeth; Espevik, Terje; Austgulen, Rigmor

doi:10.1016/0028-2243(94)90162-7

Cited by 83 publications

(46 citation statements)

References 27 publications

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“…Pertinent to this study, IL-1 and TNFa have been linked to the onset and progression of labor [32]. While exposure to high levels of these cytokines can be detrimental to the fetus and results in a systemic inflammatory response such as sepsis [33], exposure to selected cytokines can also be beneficial before pre-term delivery [14,34]. In fetal rabbits, IL-1 administration induced an increase in surfactant protein production, leading to earlier lung maturation [17].…”

Section: Discussionmentioning

confidence: 95%

“…We further demonstrated that classical hormones (glucocorticoids, thyroid hormone and estrogen) [8][9][10], and activators of LXR and PPARs [11][12][13], accelerate epidermal permeability barrier maturation in vitro and in vivo, whereas testosterone delays cutaneous barrier formation [9]. amniotic fluid with gestational age [14]. Second, the ontogeny of epidermal permeability barrier and lung occurs in parallel, and recent studies demonstrated that intra-amniotic administration of IL-1 (a/b) promotes lung maturation by increasing surfactant expression in fetal lamb, sheep or rabbits [15][16][17].…”

Section: Introductionmentioning

confidence: 91%

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IL-1α accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development

Jiang

Lü

Crumrine

et al. 2009

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 91%

IL-1α accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development

Jiang

Lü

Crumrine

et al. 2009

Journal of Dermatological Science

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“…Since parturition is an inflammatory process involving the rise of cytokines and prostaglandins, which stimulate the stress axis, the rise in cortisol level in the immediate prepartum period is also due to rising levels of these compounds (Halgunset et al, 1994;Kelly, 1996;Rivest, 2001).…”

Section: Discussionmentioning

confidence: 99%

Vitamin E and Selenium Supplementation Reduces Plasma Cortisol and Oxidative Stress in Dystocia-Affected Buffaloes

et al. 2007

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The aim of the study was to evaluate oxidative stress around parturition in normally calved and dystocia-affected buffaloes and the clinical efficacy of vitamin E and selenium (Se) in reducing the effects in buffaloes suffering from dystocia. Plasma cortisol concentration, erythrocytic malondialdehyde (MDA) level and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were evaluated in dystocia-affected (supplemented (n = 8) and unsupplemented (n = 5) with vitamin E and Se) and normally calved (unsupplemented; n = 6) buffaloes. The decline in plasma cortisol concentration, MDA level and SOD activity was greater in the group of dystocia-affected buffaloes supplemented with vitamin E and Se (78.62 +/- 2.7%, 13.38 +/- 9.75% and 28.83 +/- 7.72%, respectively) than in the unsupplemented group (54.33 +/- 12.62%, 3.48 +/- 4.16% and 17.69 +/- 12.93%, respectively). These results suggests that supplementation with antioxidants like vitamin E and Se may be beneficial in reducing oxidative stress in dystocia-affected buffaloes in the immediate postpartum period.

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“…Low grade leucocyte infiltration in placental tissues is a common finding in normal term deliveries 1,2 , and chorioamnionitis with high grade infiltration usually indicates intrauterine infection 3,4 . Chorioamnionitis is accompanied by high concentrations of inflammatory mediators in amniotic fluid, including pro-inflammatory cytokines (tumour necrosis factor (TNF)a, interleukin (IL)-1b, IL-6, and IL-8), and natural inhibitors of cytokines (soluble TNF receptors (p55 and p75), and IL-1 receptor antagonist (IL-1RA)) 5 -8 .…”

Section: Introductionmentioning

confidence: 99%

Histologic chorioamnionitis and umbilical serum levels of pro‐inflammatory cytokines and cytokine inhibitors

Døllner

Vatten

Halgunset

et al. 2002

BJOG

Self Cite

101

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Objective To study 1. whether leucocyte infiltration in placenta tissues is associated with elevated umbilical serum levels of inflammatory mediators, and 2. whether leucocyte infiltration in the presence of neonatal disease is associated with additional increase in mediator levels.Setting University hospital.Population Two groups of women with either normal delivery (n= 82) or delivery complicated by prolonged rupture of the membranes, clinical signs of intrauterine infection or preterm labour (n= 139).Methods Umbilical cord blood and placenta tissues were collected after delivery. Placentas were classified as non‐inflamed (i.e. without leucocyte infiltration, n= 74), or as mild (n= 84), or severe chorioamnionitis (n= 63). Mediator levels were compared between groups.Results Severe chorioamnionitis was associated with elevated levels of tumour necrosis factor (TNF)α, interleukin (IL)‐1β, IL‐6, IL‐8, soluble TNF receptor p55 and p75, IL‐1 receptor antagonist (IL‐1RA), and C‐reactive protein compared with non‐inflamed placentas (all P < 0.05). No differences were found between mild chorioamnionitis and placentas without infiltration. In all, 49 babies suffered from various perinatal diseases, such as clinical sepsis, respiratory distress and asphyxia, and 172 were healthy. Severe chorioamnionitis with subsequent neonatal disease (n= 23) had higher levels of all mediators, except IL‐1β and C‐reactive protein, than severe chorioamnionitis without neonatal disease (n= 40, all P < 0.01), but severe chorioamnionitis was also accompanied by a more intense and widely distributed leucocyte infiltration when neonatal disease developed.Conclusion High grade leucocyte infiltration in placenta tissues is associated with elevated levels of TNFα, IL‐1β, IL‐6, IL‐8, p55, p75, IL‐1RA and C‐reactive protein in umbilical serum. The presence of neonatal disease is associated with advanced chorioamnionitis, and highly elevated levels of both pro‐ and anti‐inflammatory mediators in umbilical serum.

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Cytokine levels in amniotic fluid and inflammatory changes in the placenta from normal deliveries at term

Cited by 83 publications

References 27 publications

IL-1α accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development

IL-1α accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development

Vitamin E and Selenium Supplementation Reduces Plasma Cortisol and Oxidative Stress in Dystocia-Affected Buffaloes

Histologic chorioamnionitis and umbilical serum levels of pro‐inflammatory cytokines and cytokine inhibitors

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