Cytokeratin‐positive interstitial reticulum cell sarcoma: a case report with cytological, immunohistochemical, and ultrastructural findings

Je, Kwon; Wi, Yang; Hk, Kim; Kw, Kwon; Tj, Kwon; Choi, Eun‐Jeong; Kg, Lee

doi:10.1111/j.1365-2303.2008.00634.x

Cited by 9 publications

(3 citation statements)

References 9 publications

(17 reference statements)

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“…Further negativity for both desmin and anaplastic lymphoma kinase (ALK) is helpful to exclude an inflammatory myofibroblastic tumor [6,8,9]. Most of these immunohistochemical features support the diagnosis of CIRCT in the present tumor with epithelioid cell morphology.…”

Section: Discussionmentioning

confidence: 54%

“…The lack of awareness of these tumors or their expression of cytokeratin and epithelioid morphology lead to a misdiagnosis of metastatic carcinoma, particularly when they are of nodal origin in patients with known carcinoma [2,4,7]. All such histologic mimickers have to be eliminated by combining careful light microscopic analysis with the immunohistochemical and/or ultrastructural data and the clinical details [6,8].…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity

Roy

Das

Kaushik

et al. 2015

Indian J Surg Oncol

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The tumors of dendritic/reticulum cells constitutes the rarest tumors affecting the lymphoid tissues. Among them tumors derived from fibroblastic reticular cells (FBRCs) are very rare, and those of cytokeratin (CK)-positive interstitial reticulum cells (CIRCs) origin are even more rare. These tumors can be easily misdiagnosed as tumors of other dendritic cells, myofibroblastic tumors or even metastatic poorly differentiated carcinomas. Less than twenty such cases have been reported in the literature till date. We present such a rare case of CIRC sarcoma in cervical lymph node of a 64-year-old man.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity

Roy

Das

Kaushik

et al. 2015

Indian J Surg Oncol

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“…FBRCs are considered to form the reticular network, which may facilitate the migration of lymphocytes and the transport of cytokines and other modulatory factors (3). Primary extranodal FBRC tumors (FRCTs) rarely occur and, to the best of our knowledge, only 19 cases have been reported in the literature thus far (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). However, none of these FRCT cases were located in the breast tissue.…”

Section: Introductionmentioning

confidence: 99%

Fibroblastic reticular cell tumor of the breast: A case report and review of the literature

Li¹,

Shen²,

Liang

et al. 2015

Experimental and Therapeutic Medicine

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Fibroblastic reticular cells (FBRCs) are basic mesenchymal cells that belong to the dendritic cell family. Primary extranodal FBRC tumor (FRCT) cases are rare, with only 19 cases reported in the literature thus far. However, none of these cases originated in the breast tissue. To the best of our knowledge, the present study reported the first FRCT case of the breast in a 57-year-old woman. The patient complained of a painless mass that was located in the right breast and was ~3.5×2.5 cm in size. The patient underwent modified radical mastectomy subsequent to the diagnosis of FRCT after analysis of the lumpectomy specimen. Pathological examination revealed that the tumor was mainly composed of oval and spindle cells, and was infiltrated with lymphocytes and plasma cells. The tumor cells were immunoreactive for vimentin and negative for CD21, CD35 and S-100 protein. Six axillary lymph nodes were found to have been involved. Following surgery, the patient received four cycles of mesna, doxorubicin, ifosfamide and dacarbazine regimen chemotherapy (70 mg adriamycin day 1; 2.0 g ifosfamided days 1-3; 0.4 g dacarbazine day 1-3), which cycled every 21 days. The patient was uneventfully followed-up for 20 months following chemotherapy. In conclusion, the present study reported what appeared to be the first case of primary breast FRCT. The diagnosis, treatment and prognosis details presented in this study will help improve the diagnosis of the disease.

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Fibroblastic/cytokeratin-positive interstitial reticular cell tumor of the spleen with indolent behavior: a case report with review of the literature

et al. 2022

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Cytokeratin‐positive interstitial reticulum cell sarcoma: a case report with cytological, immunohistochemical, and ultrastructural findings

Cited by 9 publications

References 9 publications

A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity

A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity

Fibroblastic reticular cell tumor of the breast: A case report and review of the literature

Fibroblastic/cytokeratin-positive interstitial reticular cell tumor of the spleen with indolent behavior: a case report with review of the literature

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