A Rare Case of Cytokeratin-Positive Interstitial Reticulum Cell Sarcoma and Review of the Entity

Abstract

The tumors of dendritic/reticulum cells constitutes the rarest tumors affecting the lymphoid tissues. Among them tumors derived from fibroblastic reticular cells (FBRCs) are very rare, and those of cytokeratin (CK)-positive interstitial reticulum cells (CIRCs) origin are even more rare. These tumors can be easily misdiagnosed as tumors of other dendritic cells, myofibroblastic tumors or even metastatic poorly differentiated carcinomas. Less than twenty such cases have been reported in the literature till date. We present such a rare case of CIRC sarcoma in cervical lymph node of a 64-year-old man.

A Rare Epicardial Cytokeratin-Positive Interstitial Reticulum Cell Tumor

“…Lymph nodes contain different types of dendritic/reticular cells, including follicular dendritic cells, interdigitating dendritic cells, and fibroblastic reticular cells (FRCs). 1) 2) FRC tumors (FRCTs) originate from FRCs and represent the rarest form of dendritic/reticular cell tumors. CIRC tumors are an extremely rare subtype of FRCTs.…”