Fibroblastic reticular cell tumor of the breast: A case report and review of the literature

Abstract

Fibroblastic reticular cells (FBRCs) are basic mesenchymal cells that belong to the dendritic cell family. Primary extranodal FBRC tumor (FRCT) cases are rare, with only 19 cases reported in the literature thus far. However, none of these cases originated in the breast tissue. To the best of our knowledge, the present study reported the first FRCT case of the breast in a 57-year-old woman. The patient complained of a painless mass that was located in the right breast and was ~3.5×2.5 cm in size. The patient underwent modified radical mastectomy subsequent to the diagnosis of FRCT after analysis of the lumpectomy specimen. Pathological examination revealed that the tumor was mainly composed of oval and spindle cells, and was infiltrated with lymphocytes and plasma cells. The tumor cells were immunoreactive for vimentin and negative for CD21, CD35 and S-100 protein. Six axillary lymph nodes were found to have been involved. Following surgery, the patient received four cycles of mesna, doxorubicin, ifosfamide and dacarbazine regimen chemotherapy (70 mg adriamycin day 1; 2.0 g ifosfamided days 1-3; 0.4 g dacarbazine day 1-3), which cycled every 21 days. The patient was uneventfully followed-up for 20 months following chemotherapy. In conclusion, the present study reported what appeared to be the first case of primary breast FRCT. The diagnosis, treatment and prognosis details presented in this study will help improve the diagnosis of the disease.

A Fibroblastic Reticular Cell Tumour Arising in the Oral Cavity: A Case Report and Review of the Literature

“…The most commonly involved nodes are the cervical and mediastinal nodes [1]. To the best of our knowledge this is the 24th documented FRCT in the literature with none of the other documented cases involving the oral cavity [4][5][6][7][8]. Other dendritic cell sarcomas reported in the oral cavity include 9 FDCSs [8] and 1 IDCS [9].…”

An Overt, Obscure Gastrointestinal Bleed Caused by a Primary Small Bowel Fibroblastic Reticular Cell Sarcoma

“…7 The first documented cases of FRCS were published by Gould et al in 1990 and described patients with disease limited to the thoracic nodes. 8 , 9 Primary extranodal reticular cell neoplasms are exceedingly rare, and case reports have identified involvement in the breast, lung, liver, spleen, and bone. 9 The literature describes a single patient with an FRCS involving the small bowel, although this lesion was thought to be metastatic from a primary lung lesion.…”

“… 8 , 9 Primary extranodal reticular cell neoplasms are exceedingly rare, and case reports have identified involvement in the breast, lung, liver, spleen, and bone. 9 The literature describes a single patient with an FRCS involving the small bowel, although this lesion was thought to be metastatic from a primary lung lesion. 7 Cells from FRCS are derived from mesenchymal cells and express myofibroblastic-like features, such as vimentin and desmin.…”

“…They are negative for CD21, CD35, and S-100. 9 , 10 There is little in the literature on the management of these patients, and the only treatment described is surgical resection. The role for chemotherapy, immunotherapy, or radiation remains unclear.…”

Nonlymphoid Hematopoietic Diseases Presenting in Bone, Soft Tissue, and Other Extranodal Sites

“…These tumors have also been referred to as cytokeratin-positive interstitial reticulum cell tumors and have been documented to present in lymph nodes, spleen, and soft tissue. [64][65][66][67][68] Not enough data are available to assess the genetic landscape or overall prognosis of this neoplasm, although the few reported cases had locally aggressive growth akin to that of a low-grade sarcoma.…”