Cytohistological and immunohistochemical features of a mammary invasive pleomorphic lobular carcinoma in a dog

Salgado, Breno S.; Monteiro, Leonardo de Almeida; Colodel, Marcia Moleta; Figueiroa, Fernanda C.; Nonogaki, Suely; Rocha, Noeme Sousa

doi:10.1007/s00580-012-1516-4

Cited by 2 publications

(9 citation statements)

References 11 publications

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“…Mammary gland tumours are one of the most common neoplasms of female dogs, being the simple and complex carcinoma the most frequent type of malignant disease. (1,2). Pleomorphic lobular carcinoma (PLC) is an uncommon and special type of malignant mammary neoplasia that corresponds to a variant of invasive lobular carcinomas (ILC) in women (3).…”

Section: Introductionmentioning

confidence: 99%

“…It is characterised as an aggressive tumour with poor prognosis, with the first case described within a female dog published in 2002 (4). The study compared the cytomorphological and immunohistochemical findings of mammary neoplasm in female dogs and women, showing similarities between species (1,2,4).…”

Section: Introductionmentioning

confidence: 99%

“…The cells show abundant eosinophilic cytoplasm and eccentric nuclei, similar to plasm cells. Pleomorphism is also present in nuclei, where often, bizarre and multinucleated cells can be noticed (2).…”

Section: Introductionmentioning

confidence: 99%

“…PLCs are known to be immunohistochemically positive for hormone receptors, in addition to having a high proliferation rate represented by the Ki-67 positive cells percentage, and positive expression of human epidermal growth factor receptor 2 (HER-2) (2,5). The absence of E-cadherin (E-cad) and β-catenin membranous staining is characteristic of PLC for women and female dogs, and it has been suggested that loss of these markers 34 can help the diagnose PLC in both species (2)(3)(4)(5)(6). Strong immunostaining of cytoplasmic cells to cytokeratins can define the epithelial origin of PLC (2,7).…”

Section: Introductionmentioning

confidence: 99%

“…The absence of E-cadherin (E-cad) and β-catenin membranous staining is characteristic of PLC for women and female dogs, and it has been suggested that loss of these markers 34 can help the diagnose PLC in both species (2)(3)(4)(5)(6). Strong immunostaining of cytoplasmic cells to cytokeratins can define the epithelial origin of PLC (2,7).…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and immunohistochemical features of pleomorphic lobular mammary carcinoma in a female dog

Magalhães¹,

Santilli²,

Cintra³

et al. 2020

BJVP

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This report describes a pleomorphic lobular carcinoma (PLC) case, in an eight-year-old, female Shih Tzu dog, which attended the Veterinary Hospital of the University of Franca, Brazil. A single irregular, non-ulcerated, nonhyperaemic soft nodule, 2 cm in diameter, was observed during the clinical examination. The nodule was adhered within the deep tissues in the right caudal thoracic mammary gland. After removal of the nodule, the histopathologic examination showed that the neoplastic epithelial cells were scattered throughout the stroma in linear patterns, had abundant eosinophilic cytoplasm, eccentric nuclei and cytoplasmatic vacuoles, features compatible with the diagnosis of pleomorphic lobular carcinoma. An immunohistochemical evaluation was performed in order to better characterise the tumour. Based on the negative immunoreactivity for hormone receptors and human epidermal growth factor receptor-2 and positive expression for one of the basal markers, the basal-like triple-negative phenotype was characterized. The treatment indicated was chemotherapy with carboplatin; however, the disease progressed, and the patient had an overall survival of 47 days after surgery, confirming the aggressiveness of the disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinicopathological and immunohistochemical features of pleomorphic lobular mammary carcinoma in a female dog

Magalhães¹,

Santilli²,

Cintra³

et al. 2020

BJVP

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Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal

Carvalho,

Niza-Ribeiro,

Amorim

et al. 2023

Front. Vet. Sci.

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Dogs spontaneously develop mammary gland tumors (MGT) and exhibit striking similarities in clinical and epidemiological characteristics to human breast cancer (HBC). Descriptive and comparative analysis of HBC and canine MGT with a focus on evaluating similarities and geographical distribution were the aims of this study. HBC cases were obtained from North Regional Oncological Registry (RORENO) (2010–2015) and canine MGT cases from Vet-OncoNet (2019–2022). Analyses were performed based on published and well accepted classification systems (ICD-O-3.2 for humans and Vet-ICD-O-canine-1). Age-standardized incidence risks (ASIR) of Porto district municipalities were calculated using 2021 Portuguese census (INE) and data from the Portuguese animal registration system (SIAC). Among 7,674 HBC cases and 1,140 MGT cases, a similar age and sex distribution pattern was observed. Approximately 69.2% of HBC cases were between 40 and 69 years old, while 66.9% of MGT cases were diagnosed between 7 and 12 years old (mean age of 9.6 years, SD = 2.6). In women, Invasive breast carcinoma (8500/3) was the most common histological type (n = 5,679, 74%) while in dogs it was the Complex Carcinoma (8983.1/3) (n = 205, 39%). Cocker and Yorkshire Terriers exhibited the highest relative risks (3.2 and 1.6, p < 0.05, respectively) when compared to cross breed dogs. The municipalities' ASIR of the two species exhibited a high correlation (R = 0.85, p < 0.01) and the spatial cluster analysis revealed similar geographic hotspots. Also, higher ASIR values both in women and dogs were more frequently found in urbanized areas compared to rural areas. This research sheds light on the shared features and geographical correlation between HBC and canine MGT, highlighting the potential of cross-species environmental oncology studies.

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Cytohistological and immunohistochemical features of a mammary invasive pleomorphic lobular carcinoma in a dog

Cited by 2 publications

References 11 publications

Clinicopathological and immunohistochemical features of pleomorphic lobular mammary carcinoma in a female dog

Clinicopathological and immunohistochemical features of pleomorphic lobular mammary carcinoma in a female dog

Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal

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