Cytogenotoxicological defense of retinyl palmitate in the front damage of antineoplastics

Carvalho, Rezanio Martins; Aguiar, Rai Pablo de Sousa; Islam, Muhammad Torequl; Alencar, Marcus Viní­cius Oliveira Barros de; Mata, Ana M.; Braga, Antonio Lima; Júnior, Josemar José da Silva; Sousa, Leonardo da Rocha; Lima, Róbson Borges de; Paz, Márcia Fernanda Correia Jardim; Sousa, João Marcelo de Castro e; Melo-Cavalcante, Ana A.C.

doi:10.1016/j.etp.2017.01.013

Cited by 9 publications

(1 citation statement)

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“…Ascorbic acid (AA) (also known as vitamin C) is a vitamin found in many foods and used as a dietary supplement. It is well-known for its antioxidant activity and can be used as a prooxidant, chemo preventive agent as well as adjuvant in the cancer therapy [1,2]. However, the effect of AA supplementation on cancer is still controversial, although a number of earlier reports suggesting its applicability in cancer therapy, especially in radiation and chemoresistant carcinoma [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid, Still Controversial in Using against Cancer Resistance?

Islam¹

2018

TAPI

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Ascorbic acid is a known strong antioxidant and is evident to exert a pro-oxidative effect of high concentration/dose. Therefore, it can be used not only as a protective agent, but also as an adjuvant or direct cytotoxic agent. Resistance of cancer cells is a regular matter, stimulating scientist to search fighting tools against it. Evidences suggest that the use of ascorbic acid in cancer resistance is still controversial. This paper sketches a current scenario of ascorbic acid in cancer resistance, especially resistance occurring from chemotherapy and radiotherapy. Although, hopes are alive with the use of this vitamin in this case, but more research is needed to understand the fact clearly.

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Section: Introductionmentioning

confidence: 99%