Antioxidative defense against omeprazole-induced toxicogenetical effects in Swiss mice

Braga, Antonio Lima; Nascimento, Patrícia Bastos do; Paz, Márcia Fernanda Correia Jardim; Lima, Róbson Borges de; Santos, José Victor de Oliveira; Alencar, Marcus Viní­cius Oliveira Barros de; Meneses, Ag-Anne Pereira Melo de; Júnior, Antônio Luíz Gomes; Islam, Muhammad Torequl; Sousa, João Marcelo de Castro e; Melo‐Cavalcante, Ana Amélia de Carvalho

doi:10.1007/s43440-021-00219-1

Cited by 2 publications

(2 citation statements)

References 58 publications

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“…This is in line with similar findings in which the co-administration of OME with antioxidant agents (e.g. vitamin E) reversed the oxidative stress effect of OME and inhibited its genotoxic and mutagenic effects (Guduru and Rohit, 2016;Braga et al, 2018Braga et al, , 2021Paz et al, 2020). Conversely, OME has been reported to increase in-vivo antioxidant levels and capacity (Koch et al, 2002;Biswas et al, 2003;Ganguly et al, 2006;Al-Sayed et al, 2015).…”

Section: Discussionsupporting

confidence: 89%

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

Akindele,

Oyerinde,

Olatoye

et al. 2023

Annals of Science and Technology

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Despite the widespread use of omeprazole (OME), there are still concerns about its long-term safety and tolerability, especially with long-term or indiscriminate use. This study was designed to evaluate the effect of 90 days sub-chronic administration of OME on haematological, biochemical, antioxidant, reproductive and histopathological parameters in male and female rats. Forty-eight (48) Wistar rats of both sexes were divided into 4 groups of 6 male and 6 female animals each. Group I received 10 mL/kg normal saline, while Groups II – IV received 0.12 mg/kg, 0.57 mg/kg, 2.85 mg/kg of OME respectively for 90 days. At the end of 90 days, 5 mL blood sample was collected, and vital organs were harvested for relevant analyses. In this study, OME did not elicit any significant (P>0.05) change in the body weight or weight of vital organs, but elicited a significant (P<0.05) reduction in sperm count at the supratherapeutic dose (2.85 mg/kg). The supratherapeutic dose of OME produced significant increase in cholesterol (P<0.0001) and LDL (P<0.0001) in female rats. OME did not generally produce a significant change in haematological parameters. OME elicited a significant decrease in CAT (P<0.05) in female and combined animals. Additionally, histopathological presentations of vital organs were generally non-abnormal. From this study, it can be concluded that long term administration of OME is generally safe and tolerable, especially at lower doses. Findings from this study suggest that OME may potentially induce changes in sperm characteristics (in relation to male rats), hepatoxicity, hypercholesteremia, hyperlipidemia and thrombocytosis over a long duration, at higher doses and especially in female animals.

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Section: Discussionsupporting

confidence: 89%

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

Akindele,

Oyerinde,

Olatoye

et al. 2023

Annals of Science and Technology

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“…Findings from the studies performed using the eukaryotic A. cepa test model can be corelated to the laboratory animal and clinical studies. For instance, the toxicogenetic effects of omeprazole at 10, 20, and 40 µg/mL [38] were co-related to the omeprazole-mediated cytogenotoxicological impacts on mouse stomachs, bone marrow, and peripheral blood lymphocytes at 10, 20, and 40 mg/kg [39]. Interestingly, the same test concentrations/doses converted to regular human doses (e.g., 20, 30, or 40 mg) were found to cause genetic instability, cancer [40], and mutagenic effects in humans [41].…”

Section: Discussionmentioning

confidence: 99%

Toxicity Analysis of Some Frequently Used Food Processing Chemicals Using Allium cepa Biomonitoring System

Bhuia

Siam

Ahamed

et al. 2023

Biology

Self Cite

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Frequent use of various food processing chemical agents sometimes causes damage to our bodies by inducing cytotoxicity, genotoxicity, and mutagenesis. In Bangladesh, among various chemical agents, formalin, saccharin, and urea are vastly used for processing foodstuffs by industry and local people. This study is focused to assess the toxic effects of formalin, saccharin, and urea on the popularly used eukaryotic test model, Allium cepa L. The assay was carried out by exposing different concentrations of test samples to A. cepa at 24, 48, and 72 h, where distilled water and CuSO4·5H2O (0.6 µg/mL) were utilized as the vehicle and positive control, respectively. The root length of the onions was measured in mm, and the results propose that all the chemical agents demonstrated toxicity in onions in a concentration- and exposure-time-dependent manner. The highest root length was examined at the lower concentrations, and with the increase in the concentration of the test sample and exposure time, the RG (root growth) was inhibited due to the deposition of chemicals and hampering of cell division in the root meristematic region of A. cepa. All the chemical agents also revealed a concentration- and time-dependent adaptive effect up to 72 h inspection of 24 h and a depletion of % root growth at 72 h inspection of 48 h. Our study suggests that sufficient precautions should be confirmed during its industrial and traditional usage as a toxicological response to the chemical agents observed in the A. cepa assay.

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Antioxidative defense against omeprazole-induced toxicogenetical effects in Swiss mice

Cited by 2 publications

References 58 publications

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

Effect of 90 Days Sub-chronic Administration of Omeprazole (A Proton Pump Inhibitor) on Haematological, Biochemical, Antioxidant, Reproductive and Histopathological Parameters in Male and Female Rats

Toxicity Analysis of Some Frequently Used Food Processing Chemicals Using Allium cepa Biomonitoring System

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