Cytogenetic, fluorescence in situ hybridization, and immunohistochemistry studies in a malignant pleural solitary fibrous tumor

Torres-Olivera, Francisco Javier; Vargas, María Teresa; Torres-Gómez, Francisco Javier; Trigo, Inmaculada; Díaz, María del Carmen Legorreta; González‐Cámpora, Ricardo

doi:10.1016/j.cancergencyto.2008.11.004

Cited by 16 publications

(10 citation statements)

References 18 publications

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“…Significant gains at chromosome 8 and 25q were observed (22). Cytogenetic analyses revealed multiple chromosomal aberrations such as deletions (9) (q21qter) and a marker chromosome ish der (9)(ABL+) in a malignant pleural SFT (23). These findings support that a gene on 9q22 might be involved in the pathogenesis of SFT.…”

Section: Discussionsupporting

confidence: 71%

Expression of cd44 and mmp-2: possible association with histopathological features of pleuro-pulmonary solitary fibrous tumors

Demırağ¹,

Çakır²,

Alpar³

et al. 2011

TJPATH

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Objective: Recent studies have shown that tumor cell adhesion molecules CD44 and matrix metalloproteinases (MMP-2) are expressed strongly in many tumors and associated closely with invasion and metastasis of these tumors. Although solitary fibrous tumors (SFT) have a good prognosis, a minority behave malignantly. The aim of this study was to analyze the correlation between CD44 and MMP-2 expression with histopathological parameters in SFT. Material and Method:Haemotaxylin-Eosin stained sections of 10 patients with SFT were reexamined for evaluation of histopathological parameters. Immunostaining of CD44 and MMP-2 was performed by using the streptavidin-biotin method with mouse monoclonal antibody.Results: Our cases consisted of three male and seven female patients with a mean age of 54.5 years. Three patients had a history of asbest exposure. Complete resection was performed in 2 malignant (multiple masses) and 8 benign SFT cases. One intrapulmonary tumor was treated with pneumonectomy. 3 cases originated from the right and 7 from the left hemithorax. Tumor size ranged from 5 to 27cm. All cases expressed strong CD44. Only 2 malignant SFT and intrapulmonary SFT expressed focal MMP-2. Conclusion:Although MMP-2 positivity was observed in 2 malignant cases, CD44 positivity was not associated with malignancy criteria in solitary fibrous tumors.

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Section: Discussionsupporting

confidence: 71%

Expression of cd44 and mmp-2: possible association with histopathological features of pleuro-pulmonary solitary fibrous tumors

Demırağ¹,

Çakır²,

Alpar³

et al. 2011

TJPATH

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“…To date, there are no certain morphological characteristics that predict a poor prognosis of SFTP [11][12][13]. The usual age at diagnosis is 60 or 70 years, and it occurs in similar frequency in both sexes [3].…”

Section: Discussionmentioning

confidence: 99%

A Large Solitary Fibrous Tumor of the Pleura Associated with Massive Pleural Effusion: A Case Report and Review of the Literature

Lateef¹,

Al-Khateeb²

2019

DSAHMJ

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“…Although some prognostic factors, such as over expression of Ki-67, extension beyond the capsule and negative conversion of CD34 have been discussed, based on the criteria of malignancy developed by England and coworkers [7]. To date, the morphological characteristics that predict a poor prognosis of SFTP have not been established [8,9]. Complete resection with lung-sparing is the treatment of choice; furthermore, malignant SFTPs can also have a favorable prognosis, if complete resection is possible [1,10].…”

Section: Discussionmentioning

confidence: 99%

Malignant solitary fibrous tumor of the pleura slowly growing over 17 years: case report

Jeon

Kwon

Kim

2014

J Cardiothorac Surg

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Although a solitary fibrous tumor of the pleura (SFTP) is a rare disease, and usually has a benign course, it has a malignant potential. We report a case of malignant SFTP treated surgically. A 75- year-old female was admitted with a chief complaint of hemoptysis of two weeks duration. Computed tomography of the chest imaged a large mass in the right hemithorax, which compressed adjacent organs; however, there was no evidence of invasion. We reviewed the patient’s medical records and found that the mass had been presented for 17 years. Complete resection was achieved through a right thoracotomy and histopathologic examination confirmed a malignant SFTP.

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Cytogenetic, fluorescence in situ hybridization, and immunohistochemistry studies in a malignant pleural solitary fibrous tumor

Cited by 16 publications

References 18 publications

Expression of cd44 and mmp-2: possible association with histopathological features of pleuro-pulmonary solitary fibrous tumors

Expression of cd44 and mmp-2: possible association with histopathological features of pleuro-pulmonary solitary fibrous tumors

A Large Solitary Fibrous Tumor of the Pleura Associated with Massive Pleural Effusion: A Case Report and Review of the Literature

Malignant solitary fibrous tumor of the pleura slowly growing over 17 years: case report

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