Malignant solitary fibrous tumor of the pleura slowly growing over 17 years: case report

Abstract

Although a solitary fibrous tumor of the pleura (SFTP) is a rare disease, and usually has a benign course, it has a malignant potential. We report a case of malignant SFTP treated surgically. A 75- year-old female was admitted with a chief complaint of hemoptysis of two weeks duration. Computed tomography of the chest imaged a large mass in the right hemithorax, which compressed adjacent organs; however, there was no evidence of invasion. We reviewed the patient’s medical records and found that the mass had been presented for 17 years. Complete resection was achieved through a right thoracotomy and histopathologic examination confirmed a malignant SFTP.

A Large Solitary Fibrous Tumor of the Pleura Associated with Massive Pleural Effusion: A Case Report and Review of the Literature

“…Respiratory symptoms are the most common presenting symptoms. Other rare features include osteoarthropathy, clubbing, and hypoglycemia, which is caused by the release of insulin-like growth factor 2 [15][16][17].…”

The Potential Malignancy of a Solitary Fibrous Tumour of the Lung

“…It is widely recognised that SFTPs are rare neoplasms that are predominantly benign with no gender predilection [ 2 , 4 , 5 , 8 , 11 ]. The literature suggests that between 10 and 30% of SFTPs are malignant [ 2 , 7 , 11 ] and display the characteristics described by England et al, that is, hypercellularity, nuclear atypia, >4 mitoses per 10 high-power fields, haemorrhage, and necrosis [ 2 , 4 , 12 ]. Our findings correlate with previous reports showing positive immunohistochemistry for CD34 and bcl-2.…”

“…Prognosis of malignant SFTPs is often related to tumour size and remains poor with a 5-year survival rate reported to range between 45 and 68% [ 4 , 7 , 15 ]. Demicco et al [ 14 ] developed a novel risk stratification model for predicting the probability of metastasis based on age, tumour size, and mitotic figures ( Table 1 ).…”

“…80% of SFTs arise from the visceral pleura and may present at any age, although being more frequently encountered between the fifth and eighth decades of life [ 4 – 8 ]. SFTs generally have an indolent course and thus are often an incidental finding on chest images [ 7 ]. Although the vast majority of SFTs are benign, they do have malignant potential and therefore should be excised [ 1 , 2 , 4 ].…”

Hipoglicemia inducida por tumor fibroso solitario pulmonar: Síndrome de Doege-Potter

“…Su incidencia es de 2,8 por 100.000 pacientes hospitalizados, Cardillo y col 4 realizaron una búsqueda sistemática y encontraron 1.760 casos publicados al 2012. Estos tumores son, en su mayoría, benignos, aunque 10-30% presentan características de malignidad 3,5 .…”