The Potential Malignancy of a Solitary Fibrous Tumour of the Lung

Shukla, Rajeev; Patrini, Davide; Borg, Elaine; Lawrence, David; Hayward, Martin

doi:10.1155/2015/209490

Cited by 2 publications

(1 citation statement)

References 15 publications

(25 reference statements)

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“…La resección completa en bloque con márgenes negativos y sin enfermedad residual es el estándar de oro para el tratamiento de estos tumores. 2,6,8,[14][15][16] La videotoracoscopia (VATS) puede tener un importante papel en tumores pequeños y pediculados. 16 Se estima que la sobrevida a 10 años de los TFS intratorácicos de origen pleural o extrapleural es de 73 a 100%.…”

Section: Discussionunclassified

Grandes tumores fibrosos solitarios de la pleura. Presentación de una serie de casos

Torres-Rodríguez¹,

Herrera-Cruz²,

Peñalonzo-Bendfeldt³

2020

NCT Neumología Y Cirugía De Tórax

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Section: Discussionunclassified

Grandes tumores fibrosos solitarios de la pleura. Presentación de una serie de casos

Torres-Rodríguez¹,

Herrera-Cruz²,

Peñalonzo-Bendfeldt³

2020

NCT Neumología Y Cirugía De Tórax

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Electron Microscopic and Pathological Changes in Lung Cancer after Intratumoral Injection of Sodium Bicarbonate

Abdel-Rahman

Arram

Elhadidy

et al. 2022

CCTR

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Background: Lung cancer can be treated with surgery, chemotherapy, radiation therapy, targeted therapy and palliative care. Palliative therapy is applied for inoperable lung cancer as it induces tumour necrosis. PH of tumour tissue is acidic; application of sodium bicarbonate (SB) into lung cancer locally via bronchoscopy can change its core pH, which may lead to tumour destruction. We aimed to study the ultrastructural characteristics of lung cancer and to assess the destructive effects of sodium bicarbonate 8.4% local injection on tumour tissue integrity by light and electron microscopies. Methods: This study was conducted on 21 patients with central bronchial carcinoma diagnosed according to WHO classification 2015. Three bronchoscopic biopsies were taken; two biopsies before and one after injection of sodium bicarbonate 8.4% solution of 20 ml via transbronchial needle. All biopsies were examined by both light and electron microscopes. The first biopsy was examined to diagnose the tumour morphologically with and without immunostaining. Second and third biopsies were taken before and after SB 8.4% injection to compare pathological changes in tumour tissue integrity as well as cellular ultra-structures. Different lung cancer pathological types were included in the study. Results: Tumour tissue integrity and pathological changes were examined in biopsies before and after injection of sodium bicarbonate 8.4%. Extensive necrosis in all cell types of lung cancer was seen after injection of SB; this important finding was delineated by both light and electron microscopies. Conclusion: Preliminary ultrastructural study of small biopsy of lung tumor has a complementary role to both morphological and immunohistochemical studies. Local injection of sodium bicarbonate into lung cancer induces extensive necrosis that may reflect its important therapeutic role in lung cancer.

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The Potential Malignancy of a Solitary Fibrous Tumour of the Lung

Cited by 2 publications

References 15 publications

Grandes tumores fibrosos solitarios de la pleura. Presentación de una serie de casos

Grandes tumores fibrosos solitarios de la pleura. Presentación de una serie de casos

Electron Microscopic and Pathological Changes in Lung Cancer after Intratumoral Injection of Sodium Bicarbonate

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