Expression of cd44 and mmp-2: possible association with histopathological features of pleuro-pulmonary solitary fibrous tumors

Demırağ, Funda; Çakır, Ebru; Alpar, Sibel; Taştepe, İrfan; Kaya, Sadi

doi:10.5146/tjpath.2011.01060

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Literatürde yaklaşık 22 olgu sunumu ve bir de 24 olguluk küçük bir seri mevcuttur. Kesin tanı genellikle operasyon materyalinin histopatolojik incelemesi ile konur (3,4). İntrapulmoner SFT'lerin çok nadir görülen tümörler olması ve olgumuzun tanısının cerrahi girişim öncesi transtorasik kesici biyopsi ile konulabilmesinden dolayı olguyu literatür eşliğinde sunduk.…”

Section: Abstract: Solitary Fibrous Tumors Pleura Pulmonary Noduleunclassified

Slow Growing Pulmonary Nodule: Intrapulmonary Solitary Fibrous Tumor

Yücel¹,

Demirci²,

Erdoğan³

et al. 2016

Respir Case Rep

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Soliter fibröz tümörler (SFT) plevranın nadir görülen lokalize tümörlerindendir. Genellikle visseral plevra kaynaklı olup bir sapla plevral boşluğa doğru büyü-me eğilimindedirler. Tümörün visseral plevradan parankim içine uzanım göstererek büyümesi nadirdir; bunun yanısıra histolojik olarak viseral plevra bağlan-tısı olmadan tümörün direkt intrapulmoner gelişimi ise bundan çok daha nadir bir durumdur. Hastaların çoğu asemptomatik olup lezyon göğüs radyografilerinde tesadüfen görülür. Elli iki yaşındaki erkek hastamız, pulmoner nodül nedeni ile 1,5 yıldır takip edilmekteydi. Hastanın nodül boyutlarında büyüme olması nedeni ile transtorasik biyopsi yapıldı ve sonucu SFT olarak raporlandı. Pulmoner wedge rezeksiyonu ile de intrapulmoner SFT olarak kesinleşti. Yavaş büyüyen periferik yerleşimli pulmoner nodül tanısı ile takip edilen hastanın nodül boyutunun küçük olması-na rağmen preoperatif olarak transtorasik biyopsi ile SFT tanısı konması, cerrahi sonrası tanının intrapulmoner SFT olarak raporlanması ve SFT' lerin özelikle de intrapulmoner gelişimli olanlarının nadir görülmesi nedeni ile bu olguyu sunmayı uygun bulduk. Anahtar Sözcükler: Soliter fibröz tümör, plevra, pulmoner nodül.Solitary fibrous tumors (SFTs) are rare and localized neoplasms of the pleura. They usually grow from the visceral pleura and attached here by a pedincule, growing through the pleural space. The growth of the tumor from visceral pleura through the inside of parenchyma is rare and direct intrapulmonary growth of the tumor without histologically proven connection with the pleura is extremely rare. Most patients are asymptomatic and lesions are seen incidentally in chest radiography. A 52-year-old male patient was followed for 1.5 years for a pulmonary nodule. Transthoracic biopsy was performed due to a further growth in the nodule size and the result was reported as a SFT. Pulmonary wedge resection confirmed the diagnosis of an intrapulmonary SFT. We present this case, as the diagnosis of SFT of a slowly growing peripheral pulmonary nodule was made with transthoracic biopsy preoperatively and confirmed surgically as an intrapulmonary SFT and due to the rarity of intrapulmonary SFTs.

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Section: Abstract: Solitary Fibrous Tumors Pleura Pulmonary Noduleunclassified

Slow Growing Pulmonary Nodule: Intrapulmonary Solitary Fibrous Tumor

Yücel¹,

Demirci²,

Erdoğan³

et al. 2016

Respir Case Rep

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Primary intrapulmonary solitary fibrous tumours

et al. 2018

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Due to the extreme rarity of primary intrapulmonary solitary fibrous tumours (SFTs), their clinical course, imaging characteristics, diagnosis, treatment and prognosis are poorly understood. The present study therefore assessed the diagnosis and management of primary intrapulmonary SFTs and systematically reviewed previously reported cases in the literature. A total of 5 patients who underwent resection for primary intrapulmonary SFTs were enrolled in the present study and their clinical course, tumour characteristics, management and survival were assessed in this retrospective study. Relevant studies regarding primary intrapulmonary SFTs were searched using PubMed and tumour characteristics, clinicopathologic features, therapeutic strategy and survival outcomes were reviewed. Of the 5 cases, all were males, with a mean age of 57.6 years (range, 37–68 years). All patients were asymptomatic and were identified incidentally on routine computed tomography examination. A total of 3 patients underwent thoracotomy and 2 patients underwent video-assisted thoracoscopic surgery. All tumours were completely resected. Postoperative haemorrhage occurred in 1 patient and he received surgical intervention for haemostasis. The average hospital stay was 15 (4–22) days, and no mortality occurred. The mean length of the postoperative follow-up was 37.6 (1–67) months. One patient was lost to follow-up, and 4 patients were asymptomatic. A total of 19 studies were identified from database searches. They included a total of 45 patients: Twenty-three males and 22 females (mean age, 59.4 years; range, 7–81 years). A total of 12 patients were asymptomatic, and pain and coughing were the major symptoms. Five, one, two, four, and 17 tumours occurred in the right upper lobe, right middle lobe, right lower lobe, left upper lobe and left lower lobe, respectively. A total of 39 patients underwent surgery, 1 patient underwent radiotherapy, and 1 patient underwent radiofrequency ablation. A total of 22 patients were followed up and the mean length of the postoperative follow-up was 48 (1–168) months. One patient was diagnosed with chest wall metastases, and 5 patients succumbed to mortality. To conclude, primary intrapulmonary SFTs are extremely rare and typically identified incidentally. The present findings indicated that the left lower lobe was the most common site location and complete surgical resection is a safe and effective treatment.

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Expression of cd44 and mmp-2: possible association with histopathological features of pleuro-pulmonary solitary fibrous tumors

Cited by 2 publications

References 23 publications

Slow Growing Pulmonary Nodule: Intrapulmonary Solitary Fibrous Tumor

Slow Growing Pulmonary Nodule: Intrapulmonary Solitary Fibrous Tumor

Primary intrapulmonary solitary fibrous tumours

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