Cytodiagnosis of Soft Tissue Tumors

Fine Needle Aspiration for Clinical Triage of Extremity Soft Tissue Masses

“…The mean age of the patients at the time of FNA was 51.8 years (range, 13-91 years). The most common locations were the thigh (107), leg (57), knee (37), arm (34), hand and fingers (28), forearm (24), foot and ankle (40), shoulder (23), and back (11). The FNAC diagnosis was benign in 268 of 432 (62.0%) cases, malignant in 129 (29.9%), and nondiagnostic or indeterminate in 35 (8.1%) (Fig.…”

Fine Needle Aspiration Cytology of Soft Tissue Tumors

“…Cytodiagnosis is considered a valuable tool in the management of soft tissue tumors since, in the hands of expert pathologists, it can afford a diagnostic specificity of >90%. 7,8,13,16,18,20,35,40,49,50 Nonetheless, FNA is not without pitfalls, some of which derive from the nature of the tumors themselves, such as scarcity of cells in the aspirate of some lesions, tumor heterogeneity 28,30 and the exclusively focal nature of certain sarcomatous growths. 42 Additional difficulties include the nontypical behavior of lesions, the large variety of fibroblast and myofibroblast proliferations with very poor cytoarchitectural expressivity, and the absence of strict criteria for the diagnosis of some sarcomas (e.g., nerve sheath sarcoma).…”

Logistic Regression Analysis of High Grade Spindle Cell Neoplasms

“…However, increasing evidence supports the role of aspiration cytology in the evaluation of bone and soft tissue lesions. 3,5,8,23,25,33 Unfortunately, most published reports do not use statistical analysis of their morphologic data, and the key diagnostic features are not clearly defined.…”