Fine Needle Aspiration for Clinical Triage of Extremity Soft Tissue Masses

Ng, Vincent Y.; Thomas, Kristen; Crist, Martha; Wakely, Paul E.; Mayerson, Joel L.

doi:10.1007/s11999-009-1100-7

Cited by 58 publications

(59 citation statements)

References 31 publications

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“…Therefore, less invasive techniques have emerged [ Fine-needle aspiration is usually accepted for documentation of metastases and local recurrences, especially if prior samples are available for comparison [21]. In fact, although this technique distinguishes mesenchymal from metastatic tumors, malignant from benign lesions, and high from low grade sarcomas, it is unable to precisely subtype sarcomas [21]. In regard to this technique, the literature reports a wide range of sensitivities (86%-100%), specificities (36%-100%) and diagnostic accuracies (21.9%-98%).…”

Section: Soft Tissue Biopsiesmentioning

confidence: 99%

“…However, these studies usually exclude nondiagnostic samples, reducing the reliability of results [1]. Ng et al [21] retrospectively examined the diagnostic accuracy of 432 fine-needle aspirations performed in soft tissue masses of extremity. They reported that the nature of the lesion was indeterminate or the sample was inadequate in 8.1% of the cases.…”

Section: Soft Tissue Biopsiesmentioning

confidence: 99%

“…Subtyping and grading for malignant lesions were 77.2% and 95.2% accurate, respectively. One-fourth of all patients required a secondary biopsy before a definitive treatment [21].…”

Section: Soft Tissue Biopsiesmentioning

confidence: 99%

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Section: Soft Tissue Biopsiesmentioning

confidence: 99%

Section: Soft Tissue Biopsiesmentioning

confidence: 99%

See 1 more Smart Citation

Current Concepts in the Biopsy of Musculoskeletal Tumors

Traina

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et al. 2015

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“…The diagnostic accuracy of FNAC of soft tissue tumors in distinguishing benign and malignant lesion is very high. 5 The level of diagnostic specificity and sensitivity are approximately 95% for establishing a definite diagnosis of sarcomas. 6 Thus, it is a useful technique for the initial diagnosis of soft tissue tumors as well as for identification of recurrent and metastatic cases.…”

mentioning

confidence: 99%

Role of fine needle aspiration cytology (FNAC) in the diagnosis of soft tissue tumors

Gulzar¹,

Yasin²,

Khan³

et al. 2017

Int J Res Med Sci

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Background: Soft tissue tumors constitute a large and heterogenous group of neoplasms. Benign tumors out number their malignant counterparts by a ratio of about 100:1 in hospital population. FNAC has emerged as a major outpatient procedure for the diagnosis of soft tissue tumors due to low cost of the procedure, less complications, feasibility, quick results and high therapeutic efficiency with specificity and sensitivity of approximately 95%. The diagnostic accuracy of FNAC of soft tissue tumors in distinguishing benign and malignant lesion is also very high. The objectives of this study were to study the role of FNAC in the diagnosis of soft tissue tumors and its correlation with histopathology. Also, this study aimed at studying various cytomorphological patterns of soft tissue tumors and correlating cytological grading with histopathological grading.Methods: It was a hospital based study of 5 years which included 479 patients of all age groups, clinically presenting with soft tissue swellings. FNAC was performed. Smears were stained with Papanicolaou (PAP)/May Grunwald Geimsa (MGG). The cytological details of soft tissue tumors were studied and broadly classified into benign, malignant and indeterminate and suspicious. Cytomorphological subtyping and grading of tumors on FNAC was done. The cytological findings were correlated with the histopathological results, wherever available.Results: Benign tumors comprised of 423 cases (88.3%) and malignant tumors comprised 56 cases (11.69%)only. Maximum number of cases were seen in well differentiated/lipomatous group (339 cases) followed by spindle cell category (88 cases). Histopathological correlation carried out in 136 out of 479 cases (benign:111 and malignant :25) revealed that out of 111 cases diagnosed as benign by cytology, one case was malignant (liposarcoma) and among 25 malignant cases diagnosed by cytology one case was benign (myofibroblastoma). Overall sensitivity and specificity of FNAC was 96% and 99% respectively. Comparison of cytological and histopathological grading of 24 sarcomas showed overall concordance of 75%.Conclusions: FNAC is an excellent diagnostic modality in early diagnosis of soft tissue tumors. FNAC is highly reliable and obviates surgical procedures especially in high risk patients thus facilitating initiation of appropriate therapy and saving time and manpower. It is also highly sensitive in detecting benign soft tissue tumors and highly specific for malignant soft issue tumors.

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“…Die in der Regel mit kaum oder nur minimalen Komplikationen behaftete FNP stellt durchaus eine technisch wenig anspruchsvolle, ambulante Alternative dar im Vergleich zu einer offenen Biopsie mit deutlich größeren Risiken im Zusammenhang mit der Anäs-thesie, Nachblutung, Infektion oder Kontamination des Stichkanals. Kosteneffizienz und schnellere Verarbeitungszeiten gehören zu den weiteren wichtigen Vorteilen der FNP [1,13,14,[23][24][25]28].…”

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Zytologische Sarkomdiagnostik

Bode-Lesniewska

2010

Pathologe

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Soft tissue swelling represents a common clinical sign of a variety of neoplastic and nonneoplastic lesions. Sarcoma is rarely a cause. Fine needle biopsy as a minimally invasive, economic and accurate method is well suited for the diagnosis of inflammatory/infectious processes as well as of recurrent and metastatic disease. Cytologic diagnosis of primary soft tissue tumors is also feasible. It requires close collaboration with other medical disciplines and incorporation of clinical, radiological and morphologic findings. Clinical data such as age, gender, size and topography are important parameters. The differentiation of cells and properties of the extracellular matrix supplies clues for the differential diagnosis and forms the starting point for immunohistochemical or molecular analysis (FISH, RT-PCR). This analysis may be performed on cytological smears, paraffin embedded material of the cell blocks or on frozen material.

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Fine Needle Aspiration for Clinical Triage of Extremity Soft Tissue Masses

Cited by 58 publications

References 31 publications

Current Concepts in the Biopsy of Musculoskeletal Tumors

Current Concepts in the Biopsy of Musculoskeletal Tumors

Role of fine needle aspiration cytology (FNAC) in the diagnosis of soft tissue tumors

Zytologische Sarkomdiagnostik

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