Logistic Regression Analysis of High Grade Spindle Cell Neoplasms

Liu, Katharine; Dodge, Richard K.; Layfield, Lester J.

doi:10.1159/000331151

Cited by 10 publications

(10 citation statements)

References 18 publications

(20 reference statements)

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“…15 The presence of melanin pigment was nevertheless identified as a major diagnostic criterion for spindle cell melanoma in a recent study of highgrade spindle cell neoplasms. 16 Malignant melanoma occurs with increased frequency and from a young age in patients with XP, most of which develop in skin exposed to UV light. In a large study of 132 patients with XP in the U.S.A. (ages 0-62 years, median age 16 years), Kraemer et al 2 found that malignant skin neoplasms were reported in 70% of the patients with a median age for development of first skin cancer of 8 years.…”

Section: Discussionmentioning

confidence: 99%

A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma

Sidwell

Sandison

Wing

et al. 2006

British Journal of Dermatology

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Section: Discussionmentioning

confidence: 99%

A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma

Sidwell

Sandison

Wing

et al. 2006

British Journal of Dermatology

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“…Numerous studies have attempted to characterize the cytologic morphology of MFH. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] More than 310 cases of such tumors were investigated. In addition, low-grade MFH was also reported using the term myxofibrosarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…1 The cytologic diagnosis of MFH is even more challenging. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] To define the cytological criteria in different variants of MFH, we reviewed our cases with both cytologic and histologic materials and compared them to other, morphologically similar, sarcomas. [22][23][24][25][26]…”

mentioning

confidence: 99%

Comparative fine‐needle aspiration and pathologic study of malignant fibrous histiocytoma: Cytodiagnostic features of 95 tumors in 71 patients

Klijanienko

Caillaud²,

Lagacé

et al. 2003

Diagnostic Cytopathology

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To determine diagnostic cytomorphologic features of malignant fibrous histiocytoma (MFH) on fine-needle aspiration (FNA) materials, we reviewed the cytologic material and corresponding histologic slides of 95 tumors in 71 patients. Forty-four (46%) tumors were primary, 38 (40%) were recurrent, and 13 (14%) were metastatic. Histological variants of MFH were as follows: 52 (54.7%, 43 patients) were of the storiform/pleomorphic, seven (7.4%, five patients) were giant cells, four (4.2%, four patients) were inflammatory, and 31 (33.7%, 19 patients) were myxoid type. Review of original cytology reports showed that only 23 (24.2%) tumors were diagnosed as MFH and 68 (71.6%) as other types of malignancies. Four (4.2%) cases were reported as unsatisfactory/suspicious. Our findings showed that spindle-shaped, round, giant cells, osteoclastic-like giant, and inflammatory cells were the most consistent features that allow identification of the storiform/pleomorphic, giant cell, and inflammatory variants of MFH. The myxoid tumors had marked myxoid background matrix with spindle-shaped cells and, less frequently, round and giant cells. Pleomorphic leiomyosarcoma and dedifferentiated liposarcoma should be considered in the differential diagnosis of stroriphorm/pleomorphic, giant cells, and inflammatory variants of MFH. However, myxoid MFH may resemble their leiomyosarcoma and liposarcoma counterparts.

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“…The nuclear/cytoplasmic (N/C) ratio has been utilized for the diagnosis of carcinoma [1][2][3][4][5][6][7][8] and the grading of carcinomas. The nuclear/cytoplasmic (N/C) ratio has been utilized for the diagnosis of carcinoma [1][2][3][4][5][6][7][8] and the grading of carcinomas.…”

mentioning

confidence: 99%

“…The nuclear/cytoplasmic ratio has long been used for the interpretation of both surgical pathology and cytology specimens. The nuclear/cytoplasmic (N/C) ratio has been utilized for the diagnosis of carcinoma [1][2][3][4][5][6][7][8] and the grading of carcinomas. [9][10][11][12][13][14] The accepted definition as proposed by Koss 15 and others is nuclear cross sectional area/total cell cross sectional area.…”

mentioning

confidence: 99%

Accuracy and Reproducibility of Nuclear/Cytoplasmic Ratio Assessments in Urinary Cytology Specimens

Layfield

Esebua

Frazier

et al. 2017

Diagnostic Cytopathology

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Visual quantitation of N/C ratio showed only a fair correlation with actual N/C ratio with correlation decreasing with increasing N/C ratio. In the critical range, 0.5-0.7 N/C ratio both interobserver correlation and correlation with true N/C ratio may be insufficiently accurate for precise category assignment as used in the Paris System. Diagn. Cytopathol. 2017;45:107-112. © 2016 Wiley Periodicals, Inc.

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Logistic Regression Analysis of High Grade Spindle Cell Neoplasms

Cited by 10 publications

References 18 publications

A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma

A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma

Comparative fine‐needle aspiration and pathologic study of malignant fibrous histiocytoma: Cytodiagnostic features of 95 tumors in 71 patients

Accuracy and Reproducibility of Nuclear/Cytoplasmic Ratio Assessments in Urinary Cytology Specimens

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